Probing the Environment with Galaxy Dynamics

I present various projects to study the halo dynamics of elliptical galaxies. This allows one to study the outer mass and orbital distributions of ellipticals in different environments, and the inner distributions of groups and clusters themselves.Comment: 5 pages, 2 figs, to appear in Proc. ESO Workshop, Groups of Galaxies in the Nearby Universe (5-9 Dec 2005), eds. I. Saviane, V. Ivanov & J. Borissova (Springer-Verlag

Effective killing of the human pathogen Candida albicans by a specific inhibitor of non-essential mitotic kinesin Kip1p

Kinesins from the bipolar (Kinesin-5) family are conserved in eukaryotic organisms and play critical roles during the earliest stages of mitosis to mediate spindle pole body separation and formation of a bipolar mitotic spindle. To date, genes encoding bipolar kinesins have been reported to be essential in all organisms studied. We report the characterization of CaKip1p, the sole member of this family in the human pathogenic yeast Candida albicans. C. albicans Kip1p appears to localize to the mitotic spindle and loss of CaKip1p function interferes with normal progression through mitosis. Inducible excision of CaKIP1 revealed phenotypes unique to C. albicans, including viable homozygous Cakip1 mutants and an aberrant spindle morphology in which multiple spindle poles accumulate in close proximity to each other. Expression of the C. albicans Kip1 motor domain in Escherichia coli produced a protein with microtubule-stimulated ATPase activity that was inhibited by an aminobenzothiazole (ABT) compound in an ATP-competitive fashion. This inhibition results in ‘rigor-like’, tight association with microtubules in vitro. Upon treatment of C. albicans cells with the ABT compound, cells were killed, and terminal phenotype analysis revealed an aberrant spindle morphology similar to that induced by loss of the CaKIP1 gene. The ABT compound discovered is the first example of a fungal spindle inhibitor targeted to a mitotic kinesin. Our results also show that the non-essential nature and implementation of the bipolar motor in C. albicans differs from that seen in other organisms, and suggest that inhibitors of a non-essential mitotic kinesin may offer promise as cidal agents for antifungal drug discovery

Multiperspective analysis of erosion tolerance

Erosion tolerance is the most multidisciplinary field of soil erosion research. Scientists have shown lack in ability to adequately analyze the huge list of variables that influence soil loss tolerance definitions. For these the perspectives of erosion made by farmers, environmentalists, society and politicians have to be considered simultaneously. Partial and biased definitions of erosion tolerance may explain not only the polemic nature of the currently suggested values but also, in part, the nonadoption of the desired levels of erosion control. To move towards a solution, considerable changes would have to occur on how this topic is investigated, especially among scientists, who would have to change methods and strategies and extend the perspective of research out of the boundaries of the physical processes and the frontiers of the academy. A more effective integration and communication with the society and farmers, to learn about their perspective of erosion and a multidisciplinary approach, integrating soil, social, economic and environmental sciences are essential for improved erosion tolerance definitions. In the opinion of the authors, soil erosion research is not moving in this direction and a better understanding of erosion tolerance is not to be expected in the near future

Internship and audit expectation gap among undergraduate students in Universiti Utara Malaysia

The accounting profession has long faced the issue of an audit expectation gap: being the gap between the quality of the profession's performance,its objectives and results, and that which the society expects.Studies have been carried out worldwide to determine the effect of education in narrowing the audit expectation gap.Extending the knowledge acquired, this paper investigates whether intership program could reduce the audit expectation gap in Malaysia.Using a pre-post method, the research instrument adapted from Ferguson el al. (2000) is administered to the UUM's accounting students before and after completing an internship program.The results show a significant change in their perceptions after the internship program.However changes in perceptions may not warrant an internship program as a means of reducing the audit expectation gap as misperceptions abaut the duties of auditors for fraud prevention and detection are still found among respondents. Nevertheless, an internship can still be used to complement audit education as it is an ideal way to expose students to professional issues and enables them to have a better insight of the actual performance and duties of auditors

Towards Jetography

As the LHC prepares to start taking data, this review is intended to provide a QCD theorist's understanding and views on jet finding at hadron colliders, including recent developments. My hope is that it will serve both as a primer for the newcomer to jets and as a quick reference for those with some experience of the subject. It is devoted to the questions of how one defines jets, how jets relate to partons, and to the emerging subject of how best to use jets at the LHC.Comment: 95 pages, 28 figures, an extended version of lectures given at the CTEQ/MCNET school, Debrecen, Hungary, August 2008; v2 includes additional discussion in several places, as well as other clarifications and additional references

History of clinical transplantation

How transplantation came to be a clinical discipline can be pieced together by perusing two volumes of reminiscences collected by Paul I. Terasaki in 1991-1992 from many of the persons who were directly involved. One volume was devoted to the discovery of the major histocompatibility complex (MHC), with particular reference to the human leukocyte antigens (HLAs) that are widely used today for tissue matching.1 The other focused on milestones in the development of clinical transplantation.2 All the contributions described in both volumes can be traced back in one way or other to the demonstration in the mid-1940s by Peter Brian Medawar that the rejection of allografts is an immunological phenomenon.3,4 © 2008 Springer New York

Energetic particle influence on the Earth's atmosphere

This manuscript gives an up-to-date and comprehensive overview of the effects of energetic particle precipitation (EPP) onto the whole atmosphere, from the lower thermosphere/mesosphere through the stratosphere and troposphere, to the surface. The paper summarizes the different sources and energies of particles, principally galactic cosmic rays (GCRs), solar energetic particles (SEPs) and energetic electron precipitation (EEP). All the proposed mechanisms by which EPP can affect the atmosphere are discussed, including chemical changes in the upper atmosphere and lower thermosphere, chemistry-dynamics feedbacks, the global electric circuit and cloud formation. The role of energetic particles in Earth’s atmosphere is a multi-disciplinary problem that requires expertise from a range of scientific backgrounds. To assist with this synergy, summary tables are provided, which are intended to evaluate the level of current knowledge of the effects of energetic particles on processes in the entire atmosphere