38 research outputs found
Finite temperature effects in Coulomb blockade quantum dots and signatures of spectral scrambling
The conductance in Coulomb blockade quantum dots exhibits sharp peaks whose
spacings fluctuate with the number of electrons. We derive the
temperature-dependence of these fluctuations in the statistical regime and
compare with recent experimental results. The scrambling due to Coulomb
interactions of the single-particle spectrum with the addition of an electron
to the dot is shown to affect the temperature-dependence of the peak spacing
fluctuations. Spectral scrambling also leads to saturation in the temperature
dependence of the peak-to-peak correlator, in agreement with recent
experimental results. The signatures of scrambling are derived using discrete
Gaussian processes, which generalize the Gaussian ensembles of random matrices
to systems that depend on a discrete parameter -- in this case, the number of
electrons in the dot.Comment: 14 pages, 4 eps figures included, RevTe
Spin and interaction effects in quantum dots: a Hartree-Fock-Koopmans approach
We use a Hartree-Fock-Koopmans approach to study spin and interaction effects
in a diffusive or chaotic quantum dot. In particular, we derive the statistics
of the spacings between successive Coulomb-blockade peaks. We include
fluctuations of the matrix elements of the two-body screened interaction,
surface-charge potential, and confining potential to leading order in the
inverse Thouless conductance. The calculated peak-spacing distribution is
compared with experimental results.Comment: 5 pages, 4 eps figures, revise
Behavior of the giant-dipole resonance in Sn and Pb at high excitation energ
The properties of the giant-dipole resonance (GDR) are calculated as a
function of excitation energy, angular momentum, and the compound nucleus
particle decay width in the nuclei Sn and Pb, and are compared
with recent experimental data. Differences observed in the behavior of the
full-width-at-half-maximum of the GDR for Sn and Pb are
attributed to the fact that shell corrections in Pb are stronger than
in Sn, and favor the spherical shape at low temperatures. The effects
shell corrections have on both the free energy and the moments of inertia are
discussed in detail. At high temperature, the FWHM in Sn exhibits
effects due to the evaporation width of the compound nucleus, while these
effects are predicted for Pb.Comment: 28 pages in RevTeX plus eight postscript figures. Submitted to Nucl.
Phys.
Trispecific antibody targeting HIV-1 and T cells activates and eliminates latently-infected cells in HIV/SHIV infections.
Agents that can simultaneously activate latent HIV, increase immune activation and enhance the killing of latently-infected cells represent promising approaches for HIV cure. Here, we develop and evaluate a trispecific antibody (Ab), N6/αCD3-αCD28, that targets three independent proteins: (1) the HIV envelope via the broadly reactive CD4-binding site Ab, N6; (2) the T cell antigen CD3; and (3) the co-stimulatory molecule CD28. We find that the trispecific significantly increases antigen-specific T-cell activation and cytokine release in both CD4 <sup>+</sup> and CD8 <sup>+</sup> T cells. Co-culturing CD4 <sup>+</sup> with autologous CD8 <sup>+</sup> T cells from ART-suppressed HIV <sup>+</sup> donors with N6/αCD3-αCD28, results in activation of latently-infected cells and their elimination by activated CD8 <sup>+</sup> T cells. This trispecific antibody mediates CD4 <sup>+</sup> and CD8 <sup>+</sup> T-cell activation in non-human primates and is well tolerated in vivo. This HIV-directed antibody therefore merits further development as a potential intervention for the eradication of latent HIV infection
A Solvable Regime of Disorder and Interactions in Ballistic Nanostructures, Part I: Consequences for Coulomb Blockade
We provide a framework for analyzing the problem of interacting electrons in
a ballistic quantum dot with chaotic boundary conditions within an energy
(the Thouless energy) of the Fermi energy. Within this window we show that the
interactions can be characterized by Landau Fermi liquid parameters. When ,
the dimensionless conductance of the dot, is large, we find that the disordered
interacting problem can be solved in a saddle-point approximation which becomes
exact as (as in a large-N theory). The infinite theory shows a
transition to a strong-coupling phase characterized by the same order parameter
as in the Pomeranchuk transition in clean systems (a spontaneous
interaction-induced Fermi surface distortion), but smeared and pinned by
disorder. At finite , the two phases and critical point evolve into three
regimes in the plane -- weak- and strong-coupling regimes separated
by crossover lines from a quantum-critical regime controlled by the quantum
critical point. In the strong-coupling and quantum-critical regions, the
quasiparticle acquires a width of the same order as the level spacing
within a few 's of the Fermi energy due to coupling to collective
excitations. In the strong coupling regime if is odd, the dot will (if
isolated) cross over from the orthogonal to unitary ensemble for an
exponentially small external flux, or will (if strongly coupled to leads) break
time-reversal symmetry spontaneously.Comment: 33 pages, 14 figures. Very minor changes. We have clarified that we
are treating charge-channel instabilities in spinful systems, leaving
spin-channel instabilities for future work. No substantive results are
change