713 research outputs found
Proton-proton bremsstrahlung below and above pion-threshold: the influence of the -isobar
The proton-proton bremsstrahlung is investigated within a coupled-channel
model with the degree of freedom. The model is consistent with the
scattering up to 1 GeV and the vertex determined in the
study of pion photoproduction reactions. It is found that the
excitation can significantly improve the agreements with the at MeV. Predictions at and MeV are
presented for future experimental tests.Comment: 26 pages Revtex, 12 figures are available from the authors upon
request ([email protected]
Programmed Death-Ligand 1 Expression in Lung Cancer and Paired Brain Metastases-a Single-Center Study in 190 Patients.
Expression of programmed death-ligand 1 (PD-L1) is the only routinely used tissue biomarker for predicting response to programmed cell death protein 1/PD-L1 inhibitors. It is to date unclear whether PD-L1 expression is preserved in brain metastases (BMs).
In this single-center, retrospective study, we evaluated PD-L1 expression using the SP263 assay in consecutively resected BMs of lung carcinomas and paired primary tumors, diagnosed from 2000 to 2015, with correlation to clinicopathological and molecular tumor and patient characteristics.
PD-L1 tumor proportional score (TPS) could be evaluated on whole tissue slides in 191 BMs and 84 paired primary lung carcinomas. PD-L1 TPS was less than 1% in 113 of 191 (59.2%), 1% to 49% in 34 of 191 (17.8%), and greater than or equal to 50% in 44 of 191 (23.0%) BMs. TPS was concordant between BMs and paired primary lung carcinomas in most cases, with discordance regarding the clinically relevant cutoffs at 1% and 50% in 18 of 84 patients (21.4%). Four of 18 discordant cases had no shared mutations between the primary lung carcinoma and BM. Intratumoral heterogeneity, as assessed using tissue microarray cores, was only significant at the primary site (p <sub>Wilcoxon signed rank</sub> = 0.002) with higher PD-L1 TPS at the infiltration front (mean = 40.4%, interquartile range: 0%-90%). Neither TPS greater than or equal to 1% nor TPS greater than or equal to 50% nor discordance between the primary lung carcinoma and BMs had prognostic significance regarding overall survival or BM-specific overall survival.
PD-L1 expression was mostly concordant between primary lung carcinoma and its BM and between resections of BM and stereotactic biopsies, mirrored by tissue microarray cores. Differences in PD-L1 TPS existed primarily in cases with TPS greater than 10%, for which also human assessment tends to be most error prone
Three-body decay of the d* dibaryon
Under certain circumstances, a three-body decay width can be approximated by
an integral involving a product of two off-shell two-body decay widths. This
``angle-average'' approximation is used to calculate the decay width
of the dibaryon in a simple model for the most
important Feynman diagrams describing pion emissions with baryon-baryon recoil
and meson retardation. The decay width is found to be about 0.006 (0.07, 0.5)
MeV at the mass of 2065 (2100, 2150) MeV for input dynamics derived from
the Full Bonn potential. The smallness of this width is qualitatively
understood as the result of the three-body decay being ``third forbidden''. The
concept of forbiddenness and the threshold behavior of a three-body
decay are further studied in connection with the decay of the dibaryon
where the idea of unfavorness has to be introduced.
The implications of these results are briefly discussed.Comment: 15 pages, RevTeX, two-column journal style, six figure
Recommended from our members
Temporal evolution of stable water isotopologues in cloud droplets in a hill cap cloud in central Europe (HCCT-2010)
In this work, we present the first study resolving the temporal evolution of δ2H and δ18O values in cloud droplets during 13 different cloud events. The cloud events were probed on a 937 m high mountain chain in Germany in the framework of the Hill Cap Cloud Thuringia 2010 campaign (HCCT-2010) in September and October 2010. The δ values of cloud droplets ranged from −77‰ to −15‰ (δ2H) and from −12.1‰ to −3.9‰ (δ18O) over the whole campaign. The cloud water line of the measured δ values was δ2H=7.8×δ18O+13×10−3, which is of similar slope, but with higher deuterium excess than other Central European Meteoric Water Lines. Decreasing δ values in the course of the campaign agree with seasonal trends observed in rain in central Europe. The deuterium excess was higher in clouds developing after recent precipitation revealing episodes of regional moisture recycling. The variations in δ values during one cloud event could either result from changes in meteorological conditions during condensation or from variations in the δ values of the water vapor feeding the cloud. To test which of both aspects dominated during the investigated cloud events, we modeled the variation in δ values in cloud water using a closed box model. We could show that the variation in δ values of two cloud events was mainly due to changes in local temperature conditions. For the other eleven cloud events, the variation was most likely caused by changes in the isotopic composition of the advected and entrained vapor. Frontal passages during two of the latter cloud events led to the strongest temporal changes in both δ2H (≈ 6‰ per hour) and δ18O (≈ 0.6‰ per hour). Moreover, a detailed trajectory analysis for the two longest cloud events revealed that variations in the entrained vapor were most likely related to rain out or changes in relative humidity and temperature at the moisture source region or both. This study illustrates the sensitivity of stable isotope composition of cloud water to changes in large scale air mass properties and regional recycling of moisture
CFTR protects against Mycobacterium abscessus infection by fine-tuning host oxidative defenses
Infection by rapidly growing Mycobacterium abscessus is increasingly prevalent in cystic fibrosis (CF), a genetic disease caused by a defective CF transmembrane conductance regulator (CFTR). However, the potential link between a dysfunctional CFTR and vulnerability to M. abscessus infection remains unknown. Herein, we exploit a CFTR-depleted zebrafish model, recapitulating CF immuno-pathogenesis, to study the contribution of CFTR in innate immunity against M. abscessus infection. Loss of CFTR increases susceptibility to infection through impaired NADPH oxidase-dependent restriction of intracellular growth and reduced neutrophil chemotaxis, which together compromise granuloma formation and integrity. As a consequence, extracellular multiplication of M. abscessus expands rapidly, inducing abscess formation and causing lethal infections. Because these phenotypes are not observed with other mycobacteria, our findings highlight the crucial and specific role of CFTR in the immune control of M. abscessus by mounting effective oxidative responses
The Planetary Nebula Luminosity Function at the Dawn of Gaia
The [O III] 5007 Planetary Nebula Luminosity Function (PNLF) is an excellent
extragalactic standard candle. In theory, the PNLF method should not work at
all, since the luminosities of the brightest planetary nebulae (PNe) should be
highly sensitive to the age of their host stellar population. Yet the method
appears robust, as it consistently produces < 10% distances to galaxies of all
Hubble types, from the earliest ellipticals to the latest-type spirals and
irregulars. It is therefore uniquely suited for cross-checking the results of
other techniques and finding small offsets between the Population I and
Population II distance ladders. We review the calibration of the method and
show that the zero points provided by Cepheids and the Tip of the Red Giant
Branch are in excellent agreement. We then compare the results of the PNLF with
those from Surface Brightness Fluctuation measurements, and show that, although
both techniques agree in a relative sense, the latter method yields distances
that are ~15% larger than those from the PNLF. We trace this discrepancy back
to the calibration galaxies and argue that, due to a small systematic error
associated with internal reddening, the true distance scale likely falls
between the extremes of the two methods. We also demonstrate how PNLF
measurements in the early-type galaxies that have hosted Type Ia supernovae can
help calibrate the SN Ia maximum magnitude-rate of decline relation. Finally,
we discuss how the results from space missions such as Kepler and Gaia can help
our understanding of the PNLF phenomenon and improve our knowledge of the
physics of local planetary nebulae.Comment: 12 pages, invited review at the conference "The Fundamental Cosmic
Distance Scale: State of the Art and Gaia Perspective", to appear in
Astrophysics and Space Scienc
Dilepton Spectra from Decays of Light Unflavored Mesons
The invariant mass spectrum of the and pairs
from decays of light unflavored mesons with masses below the -meson mass to final states containing along with a dilepton pair one
photon, one meson, and two mesons are calculated within the framework of the
effective meson theory. The results can be used for simulations of the dilepton
spectra in heavy-ion collisions and for experimental searches of dilepton meson
decays.Comment: 73 pages, 19 figures, 3 tables, REVTeX, new references adde
Demagnetization via Nucleation of the Nonequilibrium Metastable Phase in a Model of Disorder
We study both analytically and numerically metastability and nucleation in a
two-dimensional nonequilibrium Ising ferromagnet. Canonical equilibrium is
dynamically impeded by a weak random perturbation which models homogeneous
disorder of undetermined source. We present a simple theoretical description,
in perfect agreement with Monte Carlo simulations, assuming that the decay of
the nonequilibrium metastable state is due, as in equilibrium, to the
competition between the surface and the bulk. This suggests one to accept a
nonequilibrium "free-energy" at a mesoscopic/cluster level, and it ensues a
nonequilibrium "surface tension" with some peculiar low-T behavior. We
illustrate the occurrence of intriguing nonequilibrium phenomena, including:
(i) Noise-enhanced stabilization of nonequilibrium metastable states; (ii)
reentrance of the limit of metastability under strong nonequilibrium
conditions; and (iii) resonant propagation of domain walls. The cooperative
behavior of our system may also be understood in terms of a Langevin equation
with additive and multiplicative noises. We also studied metastability in the
case of open boundaries as it may correspond to a magnetic nanoparticle. We
then observe burst-like relaxation at low T, triggered by the additional
surface randomness, with scale-free avalanches which closely resemble the type
of relaxation reported for many complex systems. We show that this results from
the superposition of many demagnetization events, each with a well- defined
scale which is determined by the curvature of the domain wall at which it
originates. This is an example of (apparent) scale invariance in a
nonequilibrium setting which is not to be associated with any familiar kind of
criticality.Comment: 26 pages, 22 figure
Attitudes toward westbound refugees in the East German press
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67107/2/10.1177_002200277001400303.pd
- …