491 research outputs found
Gaps in the clinical management of influenza a century since the 1918 pandemic
This year marks the centennial of the devastating 1918 influenza A(H1N1) pandemic, which killed an estimated 50 million people worldwide. Prevention and control activities were limited in 1918 because global surveillance did not exist, influenza viruses were not yet discovered, and no influenza vaccines had been developed. Diagnostic tests for influenza were unavailable prior to isolation of influenza viruses in the 1930s, so spread of the pandemic virus was tracked by news reports of increased respiratory disease and related deaths. Establishment of the World Health Organization’s Global Influenza Surveillance Network in 1952 has contributed substantially to coordinated surveillance, vaccine development, and influenza vaccine strain selection
A Measurement of the Cosmic Ray Spectrum and Composition at the Knee
The energy spectrum and primary composition of cosmic rays with energy
between and 3\times10^{16}\unit{eV} have been studied using
the CASA-BLANCA detector. CASA measured the charged particle distribution of
air showers, while BLANCA measured the lateral distribution of Cherenkov light.
The data are interpreted using the predictions of the CORSIKA air shower
simulation coupled with four different hadronic interaction codes.
The differential flux of cosmic rays measured by BLANCA exhibits a knee in
the range of 2--3 PeV with a width of approximately 0.5 decades in primary
energy. The power law indices of the differential flux below and above the knee
are and .
We present our data both as a mean depth of shower maximum and as a mean
nuclear mass. A multi-component fit using four elemental species shows the same
composition trends given by the mean quantities, and also indicates that QGSJET
and VENUS are the preferred hadronic interaction models. We find that an
initially mixed composition turns lighter between 1 and 3 PeV, and then becomes
heavier with increasing energy above 3 PeV.Comment: 25 pages, 10 figures. Submitted to Astroparticle Physic
The Neoarchaean Uyea Gneiss Complex, Shetland: an onshore fragment of the Rae Craton on the European Plate
A tract of amphibolite facies granitic gneisses and metagabbros in northern Shetland, U.K., is here named the Uyea Gneiss Complex. Zircon U–Pb dating indicates emplacement of the igneous protoliths of the complex c. 2746–2726 Ma, at a later time than most of the Archaean protoliths of the Lewisian Gneiss Complex of mainland Scotland. Calc-alkaline geochemistry of the Uyea Gneiss Complex indicates arc-affinity and a strong genetic kinship among the mafic and felsic components. Zircon Hf compositions suggest an enriched mantle source and limited interaction with older crust during emplacement. Ductile fabrics developed soon after emplacement, with zircon rims at c. 2710 Ma, but there was little further deformation until Caledonian reworking east of the Uyea Shear Zone. There is no evidence for the Palaeoproterozoic reworking that dominates large tracts of the Lewisian Gneiss Complex and of the Nagssugtoqidian Orogen of East Greenland. The more northerly location of the Uyea Gneiss Complex and extensive offshore basement of similar age implies that, prior to the opening of the North Atlantic Ocean, these rocks were contiguous with the Archaean Rae Craton
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Field Demonstrations of Logging Technologies for Reservoir Characterization
Fast Non-Adiabatic Two Qubit Gates for the Kane Quantum Computer
In this paper we apply the canonical decomposition of two qubit unitaries to
find pulse schemes to control the proposed Kane quantum computer. We explicitly
find pulse sequences for the CNOT, swap, square root of swap and controlled Z
rotations. We analyze the speed and fidelity of these gates, both of which
compare favorably to existing schemes. The pulse sequences presented in this
paper are theoretically faster, higher fidelity, and simpler than existing
schemes. Any two qubit gate may be easily found and implemented using similar
pulse sequences. Numerical simulation is used to verify the accuracy of each
pulse scheme
Dimer coverings on the Sierpinski gasket with possible vacancies on the outmost vertices
We present the number of dimers on the Sierpinski gasket
at stage with dimension equal to two, three, four or five, where one of
the outmost vertices is not covered when the number of vertices is an
odd number. The entropy of absorption of diatomic molecules per site, defined
as , is calculated to be
exactly for . The numbers of dimers on the generalized
Sierpinski gasket with and are also obtained
exactly. Their entropies are equal to , , ,
respectively. The upper and lower bounds for the entropy are derived in terms
of the results at a certain stage for with . As the
difference between these bounds converges quickly to zero as the calculated
stage increases, the numerical value of with can be
evaluated with more than a hundred significant figures accurate.Comment: 35 pages, 20 figures and 1 tabl
Propagation and Structure of Planar Streamer Fronts
Streamers often constitute the first stage of dielectric breakdown in strong
electric fields: a nonlinear ionization wave transforms a non-ionized medium
into a weakly ionized nonequilibrium plasma. New understanding of this old
phenomenon can be gained through modern concepts of (interfacial) pattern
formation. As a first step towards an effective interface description, we
determine the front width, solve the selection problem for planar fronts and
calculate their properties. Our results are in good agreement with many
features of recent three-dimensional numerical simulations.
In the present long paper, you find the physics of the model and the
interfacial approach further explained. As a first ingredient of this approach,
we here analyze planar fronts, their profile and velocity. We encounter a
selection problem, recall some knowledge about such problems and apply it to
planar streamer fronts. We make analytical predictions on the selected front
profile and velocity and confirm them numerically.
(abbreviated abstract)Comment: 23 pages, revtex, 14 ps file
Fruit and vegetable intake assessed by repeat 24 h recalls, but not by a dietary screener, is associated with skin carotenoid measurements in children
Accurate measurement of fruit and vegetable (FV) intake is important for nutrition surveillance and evaluation of dietary interventions. We compared two tools for reporting FV intake to objective measurement of skin carotenoids among children. FV cups/day was assessed by repeated 24 h dietary recalls (24H FV) and the National Cancer Institute’s All-Day Fruit and Vegetable Screener (NCI FV). Skin carotenoids were measured by repeated resonance Raman spectroscopy (RRS) of the palm. FV cups were regressed on RRS scores in unadjusted, field-based, and research-setting models with covariates feasible in each scenario. Data were baseline values from children aged 2–12 years in low-income households enrolled in a healthy eating randomized trial in four U.S. states (n = 177). Twenty-four-hour FV cups were associated with skin carotenoids in all models (p < 0.001) but NCI FV cups were not. Predicted RRS scores for discrete 24H FV cups provide a guide to interpretation of RRS in children (2 cups FV intake ~36,000 RRS units), with the research-setting scenario generally providing the narrowest prediction range (+/−1924). When self-reported data are required, 24 h recalls are more accurate than NCI FV screener data; and, when limited time, resources, or literacy must be considered, RRS scores can be quickly obtained and easily interpreted
The Pitt Bacteremia Score Predicts Mortality in Nonbacteremic Infections
Background. Predicting mortality risk in patients is important in research settings. The Pitt bacteremia score (PBS) is commonly used as a predictor of early mortality risk in patients with bloodstream infections (BSIs). We determined whether the PBS predicts 14-day inpatient mortality in nonbacteremia carbapenem-resistant Enterobacteriaceae (CRE) infections. Methods. Patients were selected from the Consortium on Resistance Against Carbapenems in Klebsiella and Other Enterobacteriaceae, a prospective, multicenter, observational study. We estimated risk ratios to analyze the predictive ability of the PBS overall and each of its components individually. We analyzed each component of the PBS in the prediction of mortality, assessed the appropriate cutoff value for the dichotomized score, and compared the predictive ability of the qPitt score to that of the PBS. Results. In a cohort of 475 patients with CRE infections, a PBS 4 was associated with mortality in patients with nonbacteremia infections (risk ratio [RR], 21.9 95% confidence interval [CI], 7.0, 68.8) and with BSIs (RR, 6.0 95% CI, 2.5, 14.4). In multivariable analysis, the hypotension, mechanical ventilation, mental status, and cardiac arrest parameters of the PBS were independent risk factors for 14-day all-cause inpatient mortality. The temperature parameter as originally calculated for the PBS was not independently associated with mortality. However, a temperature < 36.0° C vs 36° C was independently associated with mortality. A qPitt score 2 had similar discrimination as a PBS 4 in nonbacteremia infections. Conclusions. Here, we validated that the PBS and qPitt score can be used as reliable predictors of mortality in nonbacteremia CRE infections
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