Severity of Visual Field Loss at First Presentation to Glaucoma Clinics in England and Tanzania

Purpose: To compare severity of visual field (VF) loss at first presentation in glaucoma clinics in England and Tanzania. Methods: Large archives of VF records from automated perimetry were used to retrospectively examine vision loss at first presentation in glaucoma clinics in Tanzania (N = 1,502) and England (N = 9,264). Mean deviation (MD) of the worse eye at the first hospital visit was used as an estimate of detectable VF loss severity. Results: In Tanzania, 44.7% {CI95%: 42.2, 47.2} of patients presented with severe VF loss (< −20 dB), versus 4.6% {4.1, 5.0} in England. If we consider late presentation to also include cases of advanced loss (-12.01 dB to -20 dB), then the proportion of patients presenting late was 58.1% {55.6, 60.6} and 14.0% {13.3, 14.7}, respectively. The proportion of late presentations was greater in Tanzania at all ages, but the difference was particularly pronounced among working-age adults, with 50.3% {46.9, 53.7} of 18–65-year-olds presenting with advanced or severe VF loss, versus 10.2% {9.3, 11.3} in England. In both countries, men were more likely to present late than women. Conclusions: Late presentation of glaucoma is a problem in England, and an even greater challenge in Tanzania. Possible solutions are discussed, including increased community eye-care, and a more proactive approach to case finding through the use of disruptive new technologies, such as low-cost, portable diagnostic aids

Can a strongly interacting Higgs boson rescue SU(5)?

Renormalization group analyses show that the three running gauge coupling constants of the Standard Model do not become equal at any energy scale. These analyses have not included any effects of the Higgs boson's self-interaction. In this paper, I examine whether these effects can modify this conclusion.Comment: 8 pages (plus 4 postscript figures

Structure and Magnetic Fields in the Precessing Jet System SS 433 II. Intrinsic Brightness of the Jets

Deep Very Large Array imaging of the binary X-ray source SS 433, sometimes classified as a microquasar, has been used to study the intrinsic brightness distribution and evolution of its radio jets. The intrinsic brightness of the jets as a function of age at emission of the jet material tau is recovered by removal of the Doppler boosting and projection effects. We find that intrinsically the two jets are remarkably similar when compared for equal tau, and that they are best described by Doppler boosting of the form D^{2+alpha}, as expected for continuous jets. The intrinsic brightnesses of the jets as functions of age behave in complex ways. In the age range 60 < tau < 150 days, the jet decays are best represented by exponential functions of tau, but linear or power law functions are not statistically excluded. This is followed by a region out to tau ~ 250 days during which the intrinsic brightness is essentially constant. At later times the jet decay can be fit roughly as exponential or power law functions of tau.Comment: 30 Pages, 11 Figures, Submitted to Ap

The far-infrared energy distributions of Seyfert and starburst galaxies in the Local Universe: ISO photometry of the 12 micron active galaxy sample

New far-infrared photometry with ISOPHOT, onboard the Infrared Space Observatory, is presented for 58 galaxies with homogeneous published data for another 32 galaxies all belonging to the 12 micron galaxy sample. In total 29 Seyfert 1's, 35 Seyfert 2's and 12 starburst galaxies, about half of the 12 micron active galaxy sample, plus 14 normal galaxies for comparison. The ISO and the IRAS data are used to define color-color diagrams and spectral energy distributions (SED). Thermal dust emission at two temperatures (one cold at 15-30K and one warm at 50-70K) can fit the 60-200 micron SED, with a dust emissivity law proportional to the inverse square of the wavelength. Seyfert 1's and Seyfert 2's are indistinguishable longward of 100 micron, while, as already seen by IRAS, the former have flatter SEDs shortward of 60 micron. A mild anti-correlation is found between the [200 - 100] color and the "60 micron excess". We infer that this is due to the fact that galaxies with a strong starburst component, and thus a strong 60 micron flux, have a steeper far-infrared turnover. In non-Seyfert galaxies, increasing the luminosity corresponds to increasing the star formation rate, that enhances the 25 and 60 micron emission. This shifts the peak emission from around 150 micron in the most quiescent spirals to shorter than 60 micron in the strongest starburst galaxies.Comment: Accepted for publication in The Astrophysical Journal AASTeX preprint with 49 pages and 20 figures Also available at http://orion.ifsi.rm.cnr.it/publ.htm

Flow fluctuations and long-range correlations: elliptic flow and beyond

These proceedings consist of a brief overview of the current understanding of collective behavior in relativistic heavy-ion collisions. In particular, recent progress in understanding the implications of event-by-event fluctuations have solved important puzzles in existing data -- the "ridge" and "shoulder" phenomena of long-range two-particle correlations -- and have created an exciting opportunity to tightly constrain theoretical models with many new observables.Comment: 10 pages, 2 figures, Proceedings for the 22nd International Conference On Ultra-Relativistic Nucleus-Nucleus Collisions (Quark Matter 2011), Annecy, France, May 23 - 28, 2011; includes Fig. 2 which was omitted from journal submission for lack of spac

Human Immunodeficiency Virus (HIV)-Infected CCR6+ Rectal CD4+ T Cells and HIV Persistence On Antiretroviral Therapy.

BackgroundIdentifying where human immunodeficiency virus (HIV) persists in people living with HIV and receiving antiretroviral therapy is critical to develop cure strategies. We assessed the relationship of HIV persistence to expression of chemokine receptors and their chemokines in blood (n = 48) and in rectal (n = 20) and lymph node (LN; n = 8) tissue collected from people living with HIV who were receiving suppressive antiretroviral therapy.MethodsCell-associated integrated HIV DNA, unspliced HIV RNA, and chemokine messenger RNA were quantified by quantitative polymerase chain reaction. Chemokine receptor expression on CD4+ T cells was determined using flow cytometry.ResultsIntegrated HIV DNA levels in CD4+ T cells, CCR6+CXCR3+ memory CD4+ T-cell frequency, and CCL20 expression (ligand for CCR6) were highest in rectal tissue, where HIV-infected CCR6+ T cells accounted for nearly all infected cells (median, 89.7%). Conversely in LN tissue, CCR6+ T cells were infrequent, and there was a statistically significant association of cell-associated HIV DNA and RNA with CCL19, CCL21, and CXCL13 chemokines.ConclusionsHIV-infected CCR6+ CD4+ T cells accounted for the majority of infected cells in rectal tissue. The different relationships between HIV persistence and T-cell subsets and chemokines in rectal and LN tissue suggest that different tissue-specific strategies may be required to eliminate HIV persistence and that assessment of biomarkers for HIV persistence may not be generalizable between blood and other tissues

Characteristics of First-Order Vortex Lattice Melting: Jumps in Entropy and Magnetization

We derive expressions for the jumps in entropy and magnetization characterizing the first-order melting transition of a flux line lattice. In our analysis we account for the temperature dependence of the Landau parameters and make use of the proper shape of the melting line as determined by the relative importance of electromagnetic and Josephson interactions. The results agree well with experiments on anisotropic Y$_1$Ba$_2$Cu$_3$O$_{7-\delta}$ and layered Bi$_2$Sr$_2$Ca$_1$Cu$_2$O$_8$ materials and reaffirm the validity of the London model.Comment: 4 pages. We have restructured the paper to emphasize that in the London scaling regime (appropriate for YBCO) our results are essentially exact. We have also emphasized that a major controversy over the relevance of the London model to describe VL melting has been settled by this wor

Diabetic retinopathy in Tanzania: prevalence and risk factors at entry into a regional screening programme.

OBJECTIVE: The number of adults with diabetes in sub-Saharan Africa (SSA) is expected to almost double by 2035. This study investigated the prevalence of diabetic retinopathy (DR) and its risk factors at entry into a community-based screening programme. METHODS: All persons with diabetes screened for retinopathy at entry into a screening programme in Kilimanjaro Region, Tanzania between November 2010 and December 2014 were included. Fundus photographs were taken with a Topcon retinal camera following pupil dilation. Data were collected on BP, random blood sugar, duration of diabetes, BMI and visual acuity on entry. RESULTS: A total of 3187 persons were screened for DR. The prevalence of any DR was 27.9% (95%CI 26.4-29.5%) with background diabetic retinopathy (BDR), pre-proliferative diabetic retinopathy (PPDR) and proliferative diabetic retinopathy (PDR) having a prevalence of 19.1% (95% CI 17.7-20.4%), 6.0% (95%CI 5.2-6.8%) and 2.9% (95%CI 2.3-3.5%), respectively. Maculopathy was present in 16.1% (95%CI 14.8-17.4%) of participants. Multivariable logistic regression analysis for the presence of any DR found independent associations with duration of diabetes (P < 0.0001), systolic BP (P < 0.0001), random blood sugar (P < 0.0001) and attending a government hospital diabetic clinic (P = 0.0339). CONCLUSIONS: This study is the first to present data from a DR screening programme in SSA. The results will provide policymakers with data to aid planning of DR screening and treatment services in the African region. The study highlights the importance of managing comorbidities within DR screening programmes

Gravitational collapse in 2+1 dimensional AdS spacetime

We present results of numerical simulations of the formation of black holes from the gravitational collapse of a massless, minimally-coupled scalar field in 2+1 dimensional, axially-symmetric, anti de-Sitter (AdS) spacetime. The geometry exterior to the event horizon approaches the BTZ solution, showing no evidence of scalar `hair'. To study the interior structure we implement a variant of black-hole excision, which we call singularity excision. We find that interior to the event horizon a strong, spacelike curvature singularity develops. We study the critical behavior at the threshold of black hole formation, and find a continuously self-similar solution and corresponding mass-scaling exponent of approximately 1.2. The critical solution is universal to within a phase that is related to the angle deficit of the spacetime.Comment: 31 pages, 20 figures, LaTeX. Replaced with version to be published in Phys. Rev.