Biomarkers of postoperative delirium and cognitive dysfunction

Elderly surgical patients frequently experience postoperative delirium (POD) and the subsequent development of postoperative cognitive dysfunction (POCD). Clinical features include deterioration in cognition, disturbance in attention and reduced awareness of the environment and result in higher morbidity, mortality and greater utilization of social financial assistance. The aging Western societies can expect an increase in the incidence of POD and POCD. The underlying pathophysiological mechanisms have been studied on the molecular level albeit with unsatisfying small research efforts given their societal burden. Here, we review the known physiological and immunological changes and genetic risk factors, identify candidates for further studies and integrate the information into a draft network for exploration on a systems level. The pathogenesis of these postoperative cognitive impairments is multifactorial; application of integrated systems biology has the potential to reconstruct the underlying network of molecular mechanisms and help in the identification of prognostic and diagnostic biomarkers

Strengthening Deterministic Policies for POMDPs

The synthesis problem for partially observable Markov decision processes (POMDPs) is to compute a policy that satisfies a given specification. Such policies have to take the full execution history of a POMDP into account, rendering the problem undecidable in general. A common approach is to use a limited amount of memory and randomize over potential choices. Yet, this problem is still NP-hard and often computationally intractable in practice. A restricted problem is to use neither history nor randomization, yielding policies that are called stationary and deterministic. Previous approaches to compute such policies employ mixed-integer linear programming (MILP). We provide a novel MILP encoding that supports sophisticated specifications in the form of temporal logic constraints. It is able to handle an arbitrary number of such specifications. Yet, randomization and memory are often mandatory to achieve satisfactory policies. First, we extend our encoding to deliver a restricted class of randomized policies. Second, based on the results of the original MILP, we employ a preprocessing of the POMDP to encompass memory-based decisions. The advantages of our approach over state-of-the-art POMDP solvers lie (1) in the flexibility to strengthen simple deterministic policies without losing computational tractability and (2) in the ability to enforce the provable satisfaction of arbitrarily many specifications. The latter point allows taking trade-offs between performance and safety aspects of typical POMDP examples into account. We show the effectiveness of our method on a broad range of benchmarks

Mössbauer Studies of Nickel-Iron Hydrotalcites

Hydrotalcite-like Fe-Ni-hydroxides [Ni2/3IIFe1/3III(OH)2](CO3)1/6(H2O)y , [Ni3/4IIFe1/4III(OH)2]-(CO3)1/8(H2O)y and [Ni3/4II/IIIFe1/4III(OH)2](CO3)0.14(H20)y as well as the ternary oxide NaNi2/3Fe1/3O2 have been studied by 57Fe-Mössbauer spectroscopy. All samples contain Fe3+ in a high spin state. The quadrupole interaction is smaller if a magnetic splitting is present, which may indicate a non-parallel arrangement of the principal axis of the EFG and the hyperfine field. The temperature dependence of the spectra has been understood in terms of collective cluster excitations. In this model the magnetic energy of a single domain depends on the direction of the total magnetic moment and on magnetic interaction with the neighbourhood. The spectral lineshape could be fitted assum­ing uniaxial relaxation

Pushing nanoparticles with light - A femtonewton resolved measurement of optical scattering forces

Optomechanical manipulation of plasmonic nanoparticles is an area of current interest, both fundamental and applied. However, no experimental method is available to determine the forward-directed scattering force that dominates for incident light of a wavelength close to the plasmon resonance. Here, we demonstrate how the scattering force acting on a single gold nanoparticle in solution can be measured. An optically trapped 80 nm particle was repetitively pushed from the side with laser light resonant to the particle plasmon frequency. A lock-in analysis of the particle movement provides a measured value for the scattering force. We obtain a resolution of less than 3 femtonewtons which is an order of magnitude smaller than any measurement of switchable forces performed on nanoparticles in solution with single beam optical tweezers to date. We compared the results of the force measurement with Mie simulations of the optical scattering force on a gold nanoparticle and found good agreement between experiment and theory within a few fN. (C) 2016 Author(s)

Anisotropic Strain Induced Soliton Movement Changes Stacking Order and Bandstructure of Graphene Multilayers

The crystal structure of solid-state matter greatly affects its electronic properties. For example in multilayer graphene, precise knowledge of the lateral layer arrangement is crucial, since the most stable configurations, Bernal and rhombohedral stacking, exhibit very different electronic properties. Nevertheless, both stacking orders can coexist within one flake, separated by a strain soliton that can host topologically protected states. Clearly, accessing the transport properties of the two stackings and the soliton is of high interest. However, the stacking orders can transform into one another and therefore, the seemingly trivial question how reliable electrical contact can be made to either stacking order can a priori not be answered easily. Here, we show that manufacturing metal contacts to multilayer graphene can move solitons by several $\mu$m, unidirectionally enlarging Bernal domains due to arising mechanical strain. Furthermore, we also find that during dry transfer of multilayer graphene onto hexagonal Boron Nitride, such a transformation can happen. Using density functional theory modeling, we corroborate that anisotropic deformations of the multilayer graphene lattice decrease the rhombohedral stacking stability. Finally, we have devised systematics to avoid soliton movement, and how to reliably realize contacts to both stacking configurations

Ferroelectric and anomalous quantum Hall states in bare rhombohedral trilayer graphene

Nontrivial interacting phases can emerge in elementary materials. As a prime example, continuing advances in device quality have facilitated the observation of a variety of spontaneous quantum Hall-like states, a cascade of Stoner-like magnets, and an unconventional superconductor in bilayer graphene. Its natural extension, rhombohedral trilayer graphene is predicted to be even more susceptible to interactions given its even flatter low-energy bands and larger winding number. Theoretically, five spontaneous quantum Hall phases have been proposed to be candidate ground states. Here, we provide transport evidence for observing four of the five competing ordered states in interaction-maximized, dually-gated, rhombohedral trilayer graphene. In particular, at vanishing but finite magnetic fields, two states with Chern numbers 3 and 6 can be stabilized at elevated and low electric fields, respectively, and both exhibit clear magnetic hysteresis. We also reveal that the quantum Hall ferromagnets of the zeroth Landau level are ferroelectrics with spontaneous layer polarizations even at zero electric field, as evidenced by electric hysteresis. Our findings exemplify the possible birth of rich interacting electron physics in a simple elementary material

Frontal and temporal dysfunction of auditory stimulus processing in schizophrenia

Attentiondeficits have been consistently described in schizophrenia. Functional neuroimaging and electrophysiological studies have focused on anterior cingulate cortex (ACC) dysfunction as a possible mediator. However, recent basic research has suggested that the effect of attention is also observed as a relative amplification of activity in modality-associated cortical areas. In the present study, the question was addressed whether an amplification deficit is seen in the auditory cortex of schizophrenic patients during an attention-requiring choice reaction task. Twenty-one drug-free schizophrenic patients and 21 age- and sex-matched healthy controls were studied (32-channel EEG). The underlying generators of the event-related N1 component were separated in neuroanatomic space using a minimum-norm (LORETA) and a multiple dipole (BESA) approach. Both methods revealed activation in the primary auditory cortex (peak latency ≈ 100 ms) and in the area of the ACC (peak latency ≈ 130 ms). In addition, the adapted multiple dipole model also showed a temporal-radial source activation in nonprimary auditory areas (peak latency ≈ 140 ms). In schizophrenic patients, significant activation deficits were found in the ACC as well as in the left nonprimary auditory areas that differentially correlated with negative and positive symptoms. The results suggest that (1) the source in the nonprimary auditory cortex is detected only with a multiple dipole approach and (2) that the N1 generators in the ACC and in the nonprimary auditory cortex are dysfunctional in schizophrenia. This would be in line with the notion that attention deficits in schizophrenia involve an extended cortical network