Wind-tunnel investigation of thermal and pressure environments in the base of the Saturn S-IC booster from Mach 0.1 to 3.5

Wind tunnel testing of thermal and pressure in base of Saturn S-IC booste

Dissecting the Contributions of Langerhans Cells to Skin Wound Healing and the Angiogenic Niche

Mammalian skin is complex, heterogeneous, and essential for survival. It is the primary barrier that protects us from physical, microbial, and chemical hazards, and must therefore be highly regenerative. When skin is wounded, healing occurs through a series of temporally-overlapping and tightly regulated stages of inflammation, proliferation, and remodeling. Angiogenesis, the growth of new blood vessels from pre-existing vessels, occurs during the proliferative phase of repair and is essential for the formation of new, healthy tissue. Blood vessels are a vital source of oxygen, nutrients, and immune cells, and failure of these vessels to regenerate after injury results in chronic, non-healing wounds. Chronic wounds represent a staggering portion of global healthcare costs, and these costs will continue to rise as the population grows older and more diabetic. It is therefore imperative that we thoroughly characterize the signals that govern angiogenesis in order to inform the development of new, effective therapies to rescue skin revascularization and healing.The two major goals of this work are (I) to characterize the angiogenic niche in healing skin, and (II) to determine if Langerhans cells (LCs), a type of phagocytic, skin-resident immune cell, play a role in skin revascularization and repair. We provide a map of an early angiogenic niche by analyzing single-cell RNA sequencing of mouse skin wound healing. Within skin wounds, endothelial cells receive several, specialized signals from multiple cell types, including well- described interactions with fibroblasts, macrophages, and keratinocytes. These data also implicate LCs in driving angiogenesis during skin repair. Using lineage- driven reporters, three-dimensional (3D) confocal microscopy, and mouse genetics, we show that LCs are spatially situated at the leading vascular edge of skin wounds and are necessary for angiogenesis during wound repair. These data provide future avenues for the control of angiogenesis to treat disease and chronic wounds, and extend the function of LCs beyond their canonical role in antigen presentation and T-cell immunity

Probabilistic Inferences for the Sample Pearson Product Moment Correlation

Fisher’s correlation transformation is commonly used to draw inferences regarding the reliability of tests comprised of dichotomous or polytomous items. It is illustrated theoretically and empirically that omitting test length and difficulty results in inflated Type I error. An empirically unbiased correction is introduced within the transformation that is applicable under any test conditions

Influence of Vineyard Management Practices and Cultivar on Grape Berry Properties

Factors influencing berry properties of grapes are numerous and include environmental factors, management practices, and cultivar differences. Vintners are continually seeking ways to modify these variables to optimize harvest dates and ensure superior fruit quality. The most widely accepted and commonly used measures of berry maturity include pH,soluble solids concentration (SSC), and titratable acidity

Systemic Light Chain Amyloidosis Mimicking Rheumatic Disorders

Secondary amyloidosis can complicate chronic inflammatory autoimmune diseases. However, the clinical findings of primary amyloidosis may mimic those of primary rheumatologic disorders. We present the case of a 53-year-old woman who presented with dystrophic nail changes, dry eyes, bilateral carpal tunnel syndrome, Raynaud’s phenomenon, and high titer positive nucleolar pattern antinuclear antibody. She was initially misdiagnosed as having Undifferentiated Connective Tissue Disease (UCTD). On further workup, she was eventually diagnosed with lambda light chain systemic amyloidosis by abdominal fat pad biopsy. Her symptoms completely resolved after autologous stem cell transplantation. With this case, we would like to highlight the similarities in the clinical features between light chain amyloidosis and rheumatological disorders. We would also like to emphasize the importance of the prompt recognition of the clinical features of amyloidosis which are crucial to triggering appropriate diagnostic procedures, since early diagnosis is a key to improving outcomes in this disease with an otherwise poor prognosis

Redução do forrageio do iguana-negro-de-cauda-espinhosa, Ctenosaura similis (Sauria: Iguanidae), na presença de estímulos do predador

The presence of a predator may have direct and indirect effects on the behavior of the prey. Although altered behavior may help prey avoid predators, it also can have a potential impact on critical activities such as foraging. Predator-prey interactions are routinely studied in laboratory-based experiments owing to the perceived difficulties of conducting such experiments in natural settings. We conducted an experimental study under field conditions in Palo Verde National Park in northwestern Costa Rica to assess behavioral responses of Black Spiny-tailed Iguanas (Ctenosaura similis) to the presence of predators and predator cues. Free-roaming iguanas were offered mango in designated areas in the presence of a predator (Boa constrictor), a predator cue (B. constrictor feces), and a control (no predator or predator cue). Results indicate that iguanas reduced their foraging efforts in the presence of both a predator and its cue.A presença de um predador pode exercer efeitos diretos e indiretos sobre o comportamento da presa. Embora a alteração do comportamento possa ajudar a presa a evitar predadores, pode também ter um impacto potencial sobre atividades críticas, como o forrageio. As interações predador-presa são comumente estudadas em experimentos de laboratório devido às dificuldades em conduzir experimentos sob condições naturais. Conduzimos um estudo experimental em campo no Parque Nacional Palo Verde, no noroeste da Costa Rica, para avaliar as respostas dos iguanas-negros-de-cauda-espinhosa (Ctenosaura similis) à presença de predadores e de seus estímulos. Oferecemos manga a iguanas livres em áreas pré-estabelecidas na presença de um predador (Boa constrictor), de um estímulo do predador (fezes de B. constrictor) e em uma áreacontrole (sem predador ou estímulo). Os resultados indicam que os iguanas reduziram seus esforços de forrageio tanto na presença do predador como de seu estímulo

Going to the exclusive show : exhibition strategies and moviegoing memories of Disneys animated feature films in Ghent (1937-1982)

This is a case study of the exploitation and experience of Disney's animated feature films from the 1930s to the 1980s in Ghent (Belgium). It is a historical study of programming practices and financial strategies which constructed childhood memories on watching Disney. The study is a contribution to a historical understanding of the implications of global distribution of film as cultural products and the counter pull of localism. Using a multi-method approach, the argument is made that the scarce screenings were strategically programmed to uplift the moviegoing experience into something out of the ordinary in everyday life. Programming and revenue data characterize the screenings as exclusive and generating high intakes. Consequently, the remembered screenings did not exhale an easy accessible social status nor an image of pervasiveness of popular childhood film, contradictory to conventional accounts of Disney's ubiquity in popular culture

Reducing pesticide use in Iowa vineyards: Alternatives to herbicides for vineyard weed management

Mulches can play a role in vineyard management. This project explored the optimum uses and practices for applying various mulches to grape agroecosystems