19 research outputs found
Cluster properties from two-particle angular correlations in p+p collisions at = 200 and 410 GeV
We present results on two-particle angular correlations in proton-proton
collisions at center of mass energies of 200 and 410 GeV. The PHOBOS experiment
at the Relativistic Heavy Ion Collider has a uniquely large coverage for
charged particles, giving the opportunity to explore the correlations at both
short- and long-range scales. At both energies, a complex two-dimensional
correlation structure in and is observed. In the
context of an independent cluster model of short-range correlations, the
cluster size and its decay width are extracted from the two-particle
pseudorapidity correlation function and compared with previous measurements in
proton-proton and proton-antiproton collisions, as well as PYTHIA and HIJING
predictions.Comment: 10 pages, 10 figures, submitted to Phys. Rev.
Plasma levels of matrix metalloproteinase-2, -3, -10, and tissue inhibitor of metalloproteinase-1 are associated with vascular complications in patients with type 1 diabetes: The EURODIAB Prospective Complications Study
Impaired regulation of extracellular matrix remodeling by matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase (TIMP) may contribute to vascular complications in patients with type 1 diabetes. We investigated associations between plasma MMP-1, -2, -3, -9, -10 and TIMP-1, and cardiovascular disease (CVD) or microvascular complications in type 1 diabetic patients. We also evaluated to which extent these associations could be explained by low-grade inflammation (LGI) or endothelial dysfunction (ED). Methods: 493 type 1 diabetes patients (39.5 ± 9.9 years old, 51% men) from the EURODIAB Prospective Complications Study were included. Linear regression analysis was applied to investigate differences in plasma levels of MMP-1, -2, -3, -9, -10, and TIMP-1 between patients with and without CVD, albuminuria or retinopathy. All analyses were adjusted for age, sex, duration of diabetes, Hba1c and additionally for other cardiovascular risk factors including LGI and ED. Results: Patients with CVD (n = 118) showed significantly higher levels of TIMP-1 [ÎČ = 0.32 SD (95%CI: 0.12; 0.52)], but not of MMPs, than patients without CVD (n = 375). Higher plasma levels of MMP-2, MMP-3, MMP-10 and TIMP-1 were associated with higher levels of albuminuria (p-trends were 0.028, 0.004, 0.005 and 0.001, respectively). Severity of retinopathy was significantly associated with higher levels of MMP-2 (p-trend = 0.017). These associations remained significant after further adjustment for markers of LGI and ED. Conclusions: These data support the hypothesis that impaired regulation of matrix remodeling by actions of MMP-2, -3 and-10 and TIMP-1 contributes to the pathogenesis of vascular complications in type 1 diabetes
Relationship Between Risk Factors and Mortality in Type 1 Diabetic Patients in Europe: The EURODIAB Prospective Complications Study (PCS)
OBJECTIVEâThe purpose of this study was to examine risk factors for mortality in patients with type 1 diabetes