Le destin des manuscrits catholiques d’Isaac Papin après sa mort : convoitise et mystère autour de la dépouille intellectuelle d’un sympathisant janséniste

Isaac Papin (1657-1709), né calviniste, est passé à la postérité pour sa conversion au catholicisme. Après avoir été le fer de lance des pajonistes au sein du Refuge, il se convertit entre les mains de Bossuet, en 1690. La seconde partie de sa vie est beaucoup moins connue. Deux dossiers de la collection Port-Royal d’Utrecht permettent de lever le voile sur un aspect totalement inédit de son parcours : ses relations avec le milieu janséniste. Si les traces sont peu nombreuses, ses relations avec Pasquier Quesnel sont attestées. Après sa mort, ses manuscrits sont convoités et finalement récupérés par les jansénistes. Les textes qu’ils contiennent sont publiés par les soins de Quesnel, en 1713, sous le titre Les deux voies opposées en matière de religion

TRANSMIT: Training Research and Applications Network to Support the Mitigation of Ionospheric Threats

TRANSMIT is an initiative funded by the European Commission through a Marie Curie Initial Training Network (ITN). Main aim of such networks is to improve the career perspectives of researchers who are in the first five years of their research career in both public and private sectors. In particular TRANSMIT will provide a coordinated program of academic and industrial training, focused on atmospheric phenomena that can significantly impair a wide range of systems and applications that are at the core of several activities embedded in our daily life. TRANSMIT deals with the harmful effects of the ionosphere on these systems, which will become increasingly significant as we approach the next solar maximum, predicted for 2013. Main aim of the project is to develop real time integrated state of the art tools to mitigate ionospheric threats to Global Navigation Satellite Systems (GNSS) and several related applications, such as civil aviation, marine navigation and land transportation. The project will provide Europe with the next generation of researchers in this field, equipping them with skills developed through a comprehensive and coordinated training program. Theirs research projects will develop real time integrated state of the art tools to mitigate these ionospheric threats to GNSS and several applications that rely on these systems. The main threat to the reliable and safe operation of GNSS is the variable propagation conditions encountered by GNSS signals as they pass through the ionosphere. At a COST 296 MIERS (Mitigation of Ionospheric Effects on Radio Systems) workshop held at the University of Nottingham in 2008, the establishment of a sophisticated Ionospheric Perturbation Detection and Monitoring (IPDM) network (http://ipdm.nottingham.ac.uk/) was proposed by European experts and supported by the European Space Agency (ESA) as the way forward to deliver the state of the art to protect the range of essential systems vulnerable to these ionospheric threats. Through a set of carefully designed research work packages TRANSMIT will be the enabler of the IPDM network. The goal of TRANSMIT is therefore to provide a concerted training programme including taught courses, research training projects, secondments at the leading European institutions, and a set of network wide events, with summer schools, workshops and a conference, which will arm the researchers of tomorrow with the necessary skills and knowledge to set up and run the proposed service. TRANSMIT will count on an exceptional set of partners, encompassing both academia and end users, including the aerospace and satellite communications sectors, as well as GNSS system designers and service providers, major user operators and receiver manufacturers. TRANSMIT's objectives are: A. Develop new techniques to detect and monitor ionospheric threats, with the introduction of new prediction and forecasting models, mitigation tools and improved system design; B. Advance the physical modeling of the underlying processes associated with the ionospheric plasma environment and the knowledge of its influences on human activity; C. Establish a prototype of a real time system to monitor the ionosphere, capable of providing useful assistance to users, which exploits all available resources and adds value for European services and products; D. Incorporate solutions to this system that respond to all end user needs and that are applicable in all geographical regions of European interest (polar, high and mid-latitudes, equatorial region). TRANSMIT will pave the way to establish in Europe a system capable of mitigating ionospheric threats on GNSS signals in real tim

Bone Morphogenetic Protein-Transduced Human Fibroblasts Convert to Osteoblasts and Form Bone in Vivo

Experimental cell or ex vivo gene therapy for localized bone formation typically uses osteoprogenitor cells propagated from periosteum or bone marrow. Both require bone or marrow biopsies to obtain cells. We have demonstrated that implantation of gingival or dermal fibroblasts transduced with BMP ex vivo, using a recombinant adenovirus (AdCMVBMP) attached to porous biodegradable scaffolds, form bone in vivo. Here we show that BMP-7-transduced fibroblasts suspended in injectable thermoset hydrogels form complete ossicles on subcutaneous injection and repair segmental defects in rat femurs. Bone formation was preceded by an intermediate cartilage stage. To determine the fate of the implanted transduced cells, thermoset hydrogel suspensions of ex vivo BMP-7-transduced or nontransduced fibroblasts were placed in diffusion chambers and implanted to allow development in vivo without direct contact with host cells. Only the BMP-transduced fibroblasts formed bone within the diffusion chambers in vivo, revealing that BMP transduction induces osteoblastic conversion of these cells.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63216/1/107632702760184709.pd

Dzyaloshinskii-Moriya interaction in transport through single molecule transistors

The Dzyaloshinskii-Moriya interaction is shown to result in a canting of spins in a single molecule transistor. We predict non-linear transport signatures of this effect induced by spin-orbit coupling for the generic case of a molecular dimer. The conductance is calculated using a master equation and is found to exhibit a non-trivial dependence on the magnitude and direction of an external magnetic field. We show how three-terminal transport measurements allow for a determination of the coupling-vector characterizing the Dzyaloshinskii-Moriya interaction. In particular, we show how its orientation, defining the intramolecular spin chirality, can be probed with ferromagnetic electrodes

Food groups, oils and butter, and cancer of the oral cavity and pharynx

To elucidate the role of dietary habits, a study was carried out in 1992-1997 in the province of Pordenone in Northeastern Italy, and those of Rome and Latina in central Italy. Cases were 512 men and 86 women with cancer of the oral cavity and pharynx (lip, salivary glands and nasopharynx excluded) and controls were 1008 men and 483 women who had been admitted to local hospitals for a broad range of acute non-neoplastic conditions. The validated dietary section of the questionnaire included 78 foods or recipes and ten questions on fat intake patterns. After allowance for education, smoking, alcohol and total energy intake, significant trends of increasing risk with increasing intake emerged for soups, eggs, processed meats, cakes and desserts, and butter. Risk was approximately halved in the highest compared to the lowest intake quintile for coffee and tea, white bread, poultry, fish, raw and cooked vegetables, citrus fruit, and olive oil. The inverse association with oils, especially olive oil, was only slightly attenuated by allowance for vegetable intake. Thus, frequent consumption of vegetables, citrus fruit, fish and vegetable oils were the major features of a low-risk diet for cancer of the oral cavity and pharynx

High-energy scissors mode

All the orbital M1 excitations, at both low and high energies, obtained from a rotationally invariant QRPA, represent the fragmented scissors mode. The high-energy M1 strength is almost purely orbital and resides in the region of the isovector giant quadrupole resonance. In heavy deformed nuclei the high-energy scissors mode is strongly fragmented between 17 and 25 MeV (with uncertainties arising from the poor knowledge of the isovector potential). The coherent scissors motion is hindered by the fragmentation and $B(M1) < 0.25 \; \mu^2_N$ for single transitions in this region. The $(e,e^{\prime})$ cross sections for excitations above 17 MeV are one order of magnitude larger for E2 than for M1 excitations even at backward angles.Comment: 20 pages in RevTEX, 5 figures (uuencoded,put with 'figures') accepted for publication in Phys.Rev.

Role of paan chewing and dietary habits in cervical carcinoma in Chennai, India

/=5 paan day(-1)=4.0; 95% CI 1.2-13.3). Among dietary habits, the highest vs lowest intake tertile for vegetables and fruit was associated with an OR of 0.5 (95% CI 0.2-1.0). Low education level and low body weight were also risk factors for ICC, but they did not account for the associations of paan chewing and low vegetable and fruit intake. In the analyses restricted to HPV-positive cases and controls, the inverse association with vegetable and fruit intake was confirmed. Conversely, the adverse influence of paan chewing on ICC risk seemed to be attributable to a higher prevalence of cervical HPV infection in women who chewed