7,286 research outputs found
The Digital Flynn Effect: Complexity of Posts on Social Media Increases over Time
Parents and teachers often express concern about the extensive use of social
media by youngsters. Some of them see emoticons, undecipherable initialisms and
loose grammar typical for social media as evidence of language degradation. In
this paper, we use a simple measure of text complexity to investigate how the
complexity of public posts on a popular social networking site changes over
time. We analyze a unique dataset that contains texts posted by 942, 336 users
from a large European city across nine years. We show that the chosen
complexity measure is correlated with the academic performance of users: users
from high-performing schools produce more complex texts than users from
low-performing schools. We also find that complexity of posts increases with
age. Finally, we demonstrate that overall language complexity of posts on the
social networking site is constantly increasing. We call this phenomenon the
digital Flynn effect. Our results may suggest that the worries about language
degradation are not warranted
Border parasites: schistosomiasis control among Uganda's fisherfolk
Copyright @ 2012 Taylor & Francis. This article has been made publically available through the Brunel Open Access Publishing Fund.It is recognized that the control of schistosomisais in Uganda requires a focus on
fisherfolk. Large numbers suffer from this water-borne parasitic disease; notably along the shores of lakes Albert and Victoria and along the River Nile. Since 2004, a policy has been adopted of providing drugs, free of charge, to all those at risk. The strategy has been reported to be successful, but closer investigation reveals serious problems. This paper draws upon long-term research undertaken at three locations in northwestern and southeastern Uganda. It highlights consequences of not engaging with the day to day realities of fisherfolk
livelihoods; attributable, in part, to the fact that so many fisherfolk live and work in places located at the country’s international borders, and to a related
tendency to treat them as "feckless" and "ungovernable". Endeavours to roll out
treatment end up being haphazard, erratic and location-specific. In some places,
concerted efforts have been made to treat fisherfolk; but there is no effective
monitoring, and it is difficult to gauge what proportion have actually swallowed
the tablets. In other places, fisherfolk are, in practice, largely ignored, or are
actively harassed in ways that make treatment almost impossible. At all sites, the current reliance upon resident "community" drug distributors or staff based at static clinics and schools was found to be flawed.The Schistosomiasis Control Initiative, Imperial College, under the auspices of the Bill and Melinda Gates Foundation
A dynamical and kinematical model of the Galactic stellar halo and possible implications for galaxy formation scenarios
We re-analyse the kinematics of the system of blue horizontal branch field
(BHBF) stars in the Galactic halo (in particular the outer halo), fitting the
kinematics with the model of radial and tangential velocity dispersions in the
halo as a function of galactocentric distance r proposed by Sommer-Larsen,
Flynn & Christensen (1994), using a much larger sample (almost 700) of BHBF
stars. The basic result is that the character of the stellar halo velocity
ellipsoid changes markedly from radial anisotropy at the sun to tangential
anisotropy in the outer parts of the Galactic halo (r greater than approx 20
kpc). Specifically, the radial component of the stellar halo's velocity
ellipsoid decreases fairly rapidly beyond the solar circle, from approx 140 +/-
10 km/s at the sun, to an asymptotic value of 89 +/- 19 km/s at large r. The
rapid decrease in the radial velocity dispersion is matched by an increase in
the tangential velocity dispersion, with increasing r.
Our results may indicate that the Galaxy formed hierarchically (partly or
fully) through merging of smaller subsystems - the 'bottom-up' galaxy formation
scenario, which for quite a while has been favoured by most theorists and
recently also has been given some observational credibility by HST observations
of a potential group of small galaxies, at high redshift, possibly in the
process of merging to a larger galaxy (Pascarelle et al 1996).Comment: Latex, 16 pages. 2 postscript figures. Submitted to the Astrophysical
Journal. also available at http://astro.utu.fi/~cflynn/outerhalo.htm
Celecoxib decreases prostaglandin E\u3csub\u3e2\u3c/sub\u3e concentrations in nipple aspirate fluid from high risk postmenopausal women and women with breast cancer
Background
Celecoxib inhibits PGE2 production in cancerous tissue. We previously reported that PGE2 levels in nipple aspirate fluid (NAF) and plasma were not decreased in women at increased breast cancer risk who received celecoxib 200 mg twice daily (bid). The endpoints of the current study were to determine if a short course of celecoxib 400 mg bid would decrease PGE2 levels in women 1) at increased breast cancer risk, and 2) with established breast cancer.
Methods
NAF and plasma samples were collected before, 2 weeks after taking celecoxib 400 mg bid, and two weeks after washout from 26 women who were at increased breast cancer risk. From 13 women with newly diagnosed breast cancer, NAF from the incident breast and plasma were collected before and on average 2 weeks after taking celecoxib. Additionally, in nine of the 13 women with breast cancer, NAF was collected from the contralateral breast.
Results
No consistent change in NAF or plasma PGE2 levels was noted in high risk premenopausal women. NAF PGE2 levels decreased after celecoxib administration in postmenopausal high risk women (p = 0.02), and in both the NAF (p = 0.02) and plasma (p = 0.03) of women with breast cancer.
Conclusion
Celecoxib 400 mg bid taken on average for 2 weeks significantly decreased NAF, but not plasma, PGE2 levels in postmenopausal high risk women, and decreased both NAF and plasma PGE2 levels in women with newly diagnosed breast cancer. PGE2 levels may predict celecoxib breast cancer prevention and treatment efficacy. Our observations are preliminary, and larger studies to confirm and extend these findings are warranted
The coupling with relativistic heavy quarks
We report on a calculation of the coupling in lattice QCD. The
strong matrix element is directly related to the
leading order low-energy constant in heavy meson chiral perturbation theory
(HMPT) for -mesons. We carry out our calculation directly at the
-quark mass using a non-perturbatively tuned clover action that controls
discretisation effects of order and for all . Our
analysis is performed on RBC/UKQCD gauge configurations using domain wall
fermions and the Iwasaki gauge action at two lattice spacings of
GeV, GeV, and unitary pion masses down to 290
MeV. We achieve good statistical precision and control all systematic
uncertainties, giving a final result for the HMPT coupling in the continuum and at the physical light-quark
masses. This is the first calculation performed directly at the physical
-quark mass and lies in the region one would expect from carrying out an
interpolation between previous results at the charm mass and at the static
point.Comment: 7 pages, 2 figures, presented at the 31st International Symposium on
Lattice Field Theory (Lattice 2013), 29 July - 3 August 2013, Mainz, German
Ultrafast control of inelastic tunneling in a double semiconductor quantum
In a semiconductor-based double quantum well (QW) coupled to a degree of
freedom with an internal dynamics, we demonstrate that the electronic motion is
controllable within femtoseconds by applying appropriately shaped
electromagnetic pulses. In particular, we consider a pulse-driven AlxGa1-xAs
based symmetric double QW coupled to uniformly distributed or localized
vibrational modes and present analytical results for the lowest two levels.
These predictions are assessed and generalized by full-fledged numerical
simulations showing that localization and time-stabilization of the driven
electron dynamics is indeed possible under the conditions identified here, even
with a simultaneous excitations of vibrational modes.Comment: to be published in Appl.Phys.Let
Celecoxib concentration predicts decrease in prostaglandin E\u3csub\u3e2\u3c/sub\u3e concentrations in nipple aspirate fluid from high risk women
BACKGROUND: Epidemiologic studies suggest that long term low dose celecoxib use significantly lowers breast cancer risk. We previously demonstrated that 400 mg celecoxib taken twice daily for 2 weeks lowered circulating plasma and breast nipple aspirate fluid (NAF) prostaglandin (PG)E2 concentrations in post- but not premenopausal high risk women. We hypothesized that circulating concentrations of celecoxib influenced PGE2 response, and that plasma levels of the drug are influenced by menopausal status. To address these hypotheses, the aims of the study were to determine: 1) if circulating plasma concentrations of celecoxib correlated with the change in plasma or NAF PGE2 concentrations from baseline to end of treatment, and 2) whether menopausal status influenced circulating levels of celecoxib.
METHODS: Matched NAF and plasma were collected from 46 high risk women who were administered celecoxib twice daily for two weeks, 20 subjects receiving 200 mg and 26 subjects 400 mg of the agent. NAF and plasma samples were collected before and 2 weeks after taking celecoxib.
RESULTS: In women taking 400 mg bid celecoxib, plasma concentrations of the agent correlated inversely with the change in NAF PGE2 levels from pre- to posttreatment. Nonsignificant trends toward higher celecoxib levels were observed in post- compared to premenopausal women. There was a significant decrease in NAF but not plasma PGE2 concentrations in postmenopausal women who took 400 mg celecoxib (p = 0.03).
CONCLUSION: In high risk women taking 400 mg celecoxib twice daily, plasma concentrations of celecoxib correlated with downregulation of PGE2 production by breast tissue. Strategies synergistic with celecoxib to downregulate PGE2 are of interest, in order to minimize the celecoxib dose required to have an effect
Service as a Component of Graduate Training in Professional Psychology
This article examines the outcomes of a Community Service Weekend in Residence (CS-WIR) program for students engaged in graduate training in professional psychology. The data were collected from eight clinical psychology students’ feedback about their experiences during the CS-WIR as well as self-reports of perceived satisfaction and impact on various areas of professional development. Results suggested that students were satisfied with their experience in the CS-WIR and perceived that the weekend contributed to their professional development, even though the tasks of the community service project differed from tasks typical to training in professional psychology. Further, students voluntarily identified the community service project as one of the most beneficial aspects of the entire experience in terms of their professional development and noted that the likelihood to engage in future service had been significantly impacted as a result of their participation
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