A biochemical and histopathologic study showing protection and treatment of gentamicin-induced nephrotoxicity in rabbits using vitamin c

Gentamicin and vitamin C have been proposed as nephrotoxic and antioxidant, respectively. This study involved biochemical and histopathologic investigation showing protection and treatment of gentamicin-induced nephrotoxicity in rabbits using vitamin C for 26 days hypothesizing that whether vitamin C would inhibit or decrease the raised serum urea and creatinine levels. This study was conducted on 25 healthy male albino rabbits (average weight 1.5±0.2 kg), classified into 5groups: group A, B, C, D and E for nephrocurative (study-I) and  nephroprotective (study-II) studies. Control group of rabbits (group A) received only the vehicle of gentamicin ampoule. In study-I, gentamicin sulphate (GS 80 mg/kg, i.m.) was administered to group B and C rabbits for ten days, then group C rabbits received vitamin C 250 mg/Kg for remaining 16 days. Group D and E received GS 80 mg/kg and GS 80 mg/kg i.m.-vitamin C 250 mg/kg orally, respectively during whole period (26 days) of study-II. After 26 days, various biochemical parameters, i.e. serum creatinine, blood urea nitrogen (BUN), and serum antioxidant activity, and histopathologic investigations were made. Nephrotoxicity was observed in rabbit groups B, C and D as evident from significant (p<0.05) high levels of serum creatinine and BUN and low serum antioxidantlevels as compared to the levels of control group. Decrease in the levels of serum creatinine and BUN along with the increase in serum antioxidant activity was observed after vitamin C treatment in group C. While, renal-protective role of vitamin C was seen in group E as compared to the control. In conclusion, Gentamicin induced nephrotoxicity can be  attenuated or treated using vitamin C

A BIOCHEMICAL AND HISTOPATHOLOGIC STUDY SHOWING PROTECTION AND TREATMENT OF GENTAMICIN-INDUCED NEPHROTOXICITY IN RABBITS USING VITAMIN C

Gentamicin and vitamin C have been proposed as nephrotoxic and antioxidant, respectively. This study involved biochemical and histopathologic investigation showing protection and treatment of gentamicin-induced nephrotoxicity in rabbits using vitamin C for 26 days hypothesizing that whether vitamin C would inhibit or decrease the raised serum urea and creatinine levels. This study was conducted on 25 healthy male albino rabbits (average weight 1.5±0.2 kg), classified into 5 groups: group A, B, C, D and E for nephrocurative (study-I) and nephroprotective (study-II) studies. Control group of rabbits (group A) received only the vehicle of gentamicin ampoule. In study-I, gentamicin sulphate (GS 80 mg/kg, i.m.) was administered to group B and C rabbits for ten days, then group C rabbits received vitamin C 250 mg/Kg for remaining 16 days. Group D and E received GS 80 mg/kg and GS 80 mg/kg i.m.-vitamin C 250 mg/kg orally, respectively during whole period (26 days) of study-II. After 26 days, various biochemical parameters, i.e. serum creatinine, blood urea nitrogen (BUN), and serum antioxidant activity, and histopathologic investigations were made. Nephrotoxicity was observed in rabbit groups B, C and D as evident from significant (

Tongue-Supported Human-Computer Interaction Systems: A Review

The tongue can substitute human sensory systems and has been used as a medium of input to help impaired patients communicate with the world. Innovative techniques have been employed to realize tongue movement, sense its position and exploit tongue dexterity, in order to achieve Tongue Supported Human Computer Interaction (TSHCI). This paper examines various approaches of using tongue dexterousness in TSHCI systems and introduces two infrared signal supported minimally-invasive TSHCI systems developed at Curtin University. Methods of sensing tongue movement andposition are especially discussed and depending on the employed methods, TSHCI systems are categorized as either invasive or minimally-invasive. A set of system usability criteria is proposed to help build more effective TSHCI systems in future

Design of near field communication passive antenna for circular shaped wearable items

The paper discusses proposed Near Field Communication (NFC) passive antenna design for circular and round shaped wearable items like rings, watches and wristbands. Several NFC passive tags were available in the market, which had different shaped antennas, incorporated into them. However, these tags were designed with specific shape and diameter and could not fit for most of the wearable items like rings, watches and wristbands etc. In order to overcome this problem, a customized NFC antenna for passive tags was designed, which could be suitable for circular shaped wearable items. Moreover, comparative analysis of proposed antenna with vendor made antenna had been performed to show how proposed customized antenna was much more efficient in performance

DESIGN OF NEAR FIELD COMMUNICATION PASSIVE ANTENNA FOR CIRCULAR SHAPED WEARABLE ITEMS

ABSTRACT: The paper discusses proposed Near Field Communication (NFC) passive antennadesign for circular and round shaped wearable items like rings, watches and wristbands. Several NFCpassive tags were available in the market, which had different shaped antennas, incorporated into them.However, these tags were designed with specific shape and diameter and could not fit for most of thewearable items like rings, watches and wristbands etc. In order to overcome this problem, a customizedNFC antenna for passive tags was designed, which could be suitable for circular shaped wearableitems. Moreover, comparative analysis of proposed antenna with vendor made antenna had beenperformed to show how proposed customized antenna was much more efficient in performance