Interplay between structure and magnetism in Mo12S9I9Mo_{12} S_9 I_9 nanowires

We investigate the equilibrium geometry and electronic structure of Mo$_{12}$S$_{9}$I$_{9}$ nanowires using ab initio Density Functional calculations. The skeleton of these unusually stable nanowires consists of rigid, functionalized Mo octahedra, connected by flexible, bi-stable sulphur bridges. This structural flexibility translates into a capability to stretch up to approximate 20% at almost no energy cost. The nanowires change from conductors to narrow-gap magnetic semiconductors in one of their structural isomers.Comment: 4 pages with PRL standards and 3 figure

Black Holes at the LHC

If the scale of quantum gravity is near a TeV, the LHC will be producing one black hole (BH) about every second. The BH decays into prompt, hard photons and charged leptons is a clean signature with low background. The absence of significant missing energy allows the reconstruction of the mass of the decaying BH. The correlation between the BH mass and its temperature, deduced from the energy spectrum of the decay products, can test experimentally the higher dimensional Hawking evaporation law. It can also determine the number of large new dimensions and the scale of quantum gravity.Comment: 5 pages, 3 figures, submitted to PRL. Results presented at the Les Houches Workshop "Physics at the TeV Colliders" (May 30, 2001) and the "Avatars of M-Theory" conference, ITP at Santa Barbara (June 7, 2001), http://online.itp.ucsb.edu/online/mtheory_c01/dimopoulo

Low velocity quantum reflection of Bose-Einstein condensates

We studied quantum reflection of Bose-Einstein condensates at normal incidence on a square array of silicon pillars. For incident velocities of 2.5-26 mm/s observations agreed with theoretical predictions that the Casimir-Polder potential of a reduced density surface would reflect slow atoms with much higher probability. At low velocities (0.5-2.5 mm/s), we observed that the reflection probability saturated around 60% rather than increasing towards unity. We present a simple model which explains this reduced reflectivity as resulting from the combined effects of the Casimir-Polder plus mean field potential and predicts the observed saturation. Furthermore, at low incident velocities, the reflected condensates show collective excitations.Comment: 4 figure

Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function.

Rett syndrome (RTT) is a pervasive developmental disorder caused by mutations in MECP2. Complete loss of MECP2 function in males causes congenital encephalopathy, neurodevelopmental arrest, and early lethality. Induced pluripotent stem cell (iPSC) lines from male patients harboring mutations in MECP2, along with control lines from their unaffected fathers, give us an opportunity to identify some of the earliest cellular and molecular changes associated with MECP2 loss-of-function (LOF). We differentiated iPSC-derived neural progenitor cells (NPCs) using retinoic acid (RA) and found that astrocyte differentiation is perturbed in iPSC lines derived from two different patients. Using highly stringent quantitative proteomic analyses, we found that LIN28, a gene important for cell fate regulation and developmental timing, is upregulated in mutant NPCs compared to WT controls. Overexpression of LIN28 protein in control NPCs suppressed astrocyte differentiation and reduced neuronal synapse density, whereas downregulation of LIN28 expression in mutant NPCs partially rescued this synaptic deficiency. These results indicate that the pathophysiology of RTT may be caused in part by misregulation of developmental timing in neural progenitors, and the subsequent consequences of this disruption on neuronal and glial differentiation

Implementation costs of a multi-component program to increase human papillomavirus (HPV) vaccination in a network of pediatric clinics

Introduction: HPV vaccination is both a clinically and cost-effective way to prevent HPV-related cancers. Increased focus on preventing HPV infection and HPV-related cancers has motivated development of strategies to increase adolescent vaccination rates. This analysis estimates the average cost associated with implementing programs aimed at increasing HPV vaccination from the perspective of the clinic decision makers. As providers and healthcare organizations consider vaccination initiatives, it is important for them to understand the costs associated with implementing these programs. Methods: Healthcare provider assessment and feedback, reminders, and education; and parent education/reminder strategies were implemented in a large pediatric clinic network between October 2015 and February 2018 to improve HPV vaccination rates. A micro-costing method was used in 2018 to prospectively estimate program implementation costs with the clinic as the unit of analysis. A sensitivity analysis assessed the effects of variability in levels of participation. Results: Assessment and feedback reports and provider education were implemented among 51 clinics at average per clinic cost of $786 and$368 respectively. Electronic vaccination reminders were delivered to providers and parents at a per clinic cost of $824. The parent education implementation cost was$2,126 per clinic. Conclusion: The four complimentary HPV evidence-based strategies were delivered at a total cost of $157,534 or$4,749 per clinic, including staff training and participant recruitment, reaching 155,000 HPV vaccine eligible adolescents

Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in osteoclastogenesis in vivo and in vitro

Osteoclasts differentiate from hematopoietic precursors under systemic and local controls. Chemokines and receptors direct leukocyte traffic throughout the body and may help regulate site-specific bone resorption. We investigated bone gene expression in vivo during rapid osteoclast differentiation induced by colony-stimulating factor 1 (CSF-1) in Csf1-null toothless (tl/tl) rats. Long-bone RNA from CSF-1-treated tl/tl rats was analyzed by high-density microarray over a time course. TRAP (tartrate-resistant acid phosphatase)-positive osteoclasts appeared on day 2, peaked on day 4, and decreased slightly on day 6, as marrow space was expanding. TRAP and cathepsin K mRNA paralleled the cell counts. We examined all chemokine and receptor mRNAs on the arrays. CCL9 was strongly induced and peaked on day 2, as did its receptor, CCR1, and regulatory receptors c-Fms (CSF-1 receptor) and RANK (receptor activator of nuclear factor kappaB). Other chemokines and receptors showed little or no significant changes. In situ hybridization and immunohistochemistry revealed CCL9 in small, immature osteoclasts on day 2 and in mature cells at later times. Anti-CCL9 antibody inhibited osteoclast differentiation in culture and significantly suppressed the osteoclast response in CSF-1-treated tl/tl rats. While various chemokines have been implicated in osteoclastogenesis in vitro, this first systematic analysis of chemokines and receptors during osteoclast differentiation in vivo highlights the key role of CCL9 in this process

Stabilization of Sub-Millimeter Dimensions: The New Guise of the Hierarchy Problem

A new framework for solving the hierarchy problem was recently proposed which does not rely on low energy supersymmetry or technicolor. The fundamental Planck mass is at a \tev and the observed weakness of gravity at long distances is due the existence of new sub-millimeter spatial dimensions. In this picture the standard model fields are localized to a $(3+1)$-dimensional wall or ``3-brane''. The hierarchy problem becomes isomorphic to the problem of the largeness of the extra dimensions. This is in turn inextricably linked to the cosmological constant problem, suggesting the possibility of a common solution. The radii of the extra dimensions must be prevented from both expanding to too great a size, and collapsing to the fundamental Planck length \tev^{-1}. In this paper we propose a number of mechanisms addressing this question. We argue that a positive bulk cosmological constant $\bar\Lambda$ can stabilize the internal manifold against expansion, and that the value of $\bar\Lambda$ is not unstable to radiative corrections provided that the supersymmetries of string theory are broken by dynamics on our 3-brane. We further argue that the extra dimensions can be stabilized against collapse in a phenomenologically successful way by either of two methods: 1) Large, topologically conserved quantum numbers associated with higher-form bulk U(1) gauge fields, such as the naturally occurring Ramond-Ramond gauge fields, or the winding number of bulk scalar fields. 2) The brane-lattice-crystallization of a large number of 3-branes in the bulk. These mechanisms are consistent with theoretical, laboratory, and cosmological considerations such as the absence of large time variations in Newton's constant during and after primordial nucleosynthesis, and millimeter-scale tests of gravity.Comment: Corrected referencing to important earlier work by Sundrum, errors fixed, additional discussion on radion phenomenology, conclusions unchanged, 23 pages, LaTe

Corrosion Mitigation by Planar Benzimidazole Derivatives

The corrosion has a considerable amount of impact on the economics of every nation, and ultimately it affects the GDP. In the present era, the challenge given by corrosion can be easily mitigated using organic compounds as corrosion inhibitor in different corrosive media. The important property of an inhibitor is the presence of the metal interacting with heteroatoms and a planar structure. In this regard, benzimidazoles (BI) with a fused bicyclic ring consisting of benzene and imidazole moiety in their structural framework making them a potential candidate for anti-corrosion work. In addition to this, bezimidazole derivatives are classified as green inhibitor due to different kinds of biological activities. Their higher potency to mitigate corrosion is because of the planar molecular structure, nitrogen atom and sp2 hybridized carbon, which provide them an ability to strongly interact with the metal. The focus of this book chapter is to investigate briefly the anti-corrosion ability of benzimidazole (BI) and their derivatives as a potential corrosion inhibitor for various industrially useful metals in different aggressive media

Papillary microcarcinomas of the thyroid gland and immunohistochemical analysis of expression of p53 protein in papillary microcarcinomas

BACKGROUND: Thyroid papillary microcarcinoma (TPM) is defined according to WHO criteria as a thyroid tumor smaller than 1–1.5 cm. TPMs are encountered in 0.5–35.6 % of autopsies or surgical specimens where carcinoma had been unsuspected. The purpose of the present study was to evaluate patients who had TPMs in terms of clinical findings, histopathological features and immunohistochemical evidence of expression of the tumor suppressor gene p53. METHODS: A total of 44 patients with TPMs less than 1.0 cm in diameter were included in the study. The patients were evaluated clinically and the tumors were evaluated in terms of their histopathological and immunohistochemical features, including expression of p53. RESULTS: The female/male ratio was 2.8/1, and the median age at time of diagnosis was 49 years (range 20–71 years). The maximum diameter of the smallest focus was 0.1 mm, and that of the largest was 10 mm microscopically. The mean diameter of all tumors was 5.7 mm. There was no correlation between tumor size and age or gender. Of the TPMs, 72 % were found in the right lobe, 24 % in the left lobe and 4 % in the isthmus. Fine-needle aspiration biopsy provided the diagnosis of TPM in only 43.2 % of the patients. All patients were treated with surgery, with 20 undergoing conservative surgery, i.e. lobectomy or isthmusectomy, and 24 undergoing total thyroidectomy. Frozen section provided the diagnosis of TPM in only 56.8 % of the patients. We found lymphocytic thyroiditis in 13.6% of patients, follicular variants in 11.9%, capsular invasion in 26.8%, lymph node involvement in 11.9%, soft tissue metastases in the neck in 12.1% and multifocality in 31.7 %, and none of these were related to age or gender (p > 0.05). No distant metastases were observed during approximately 10 years of follow up. We found p53 positivity in 34.5 % of TPM tumors. However, p53 expression was not statistically related to age or gender. CONCLUSION: Our findings imply that TPMs may not be entirely innocent since they are associated with signs of poor prognosis such as capsular invasion, multifocal presentation, lymph node involvement and p53 positivity. Therefore, TPMs should be evaluated and followed like classical papillary cancers