5,404 research outputs found
Performance of alkaline battery cells used in emergency locator transmitters
The characteristics of battery power supplies for emergency locator transmitters (ELT's) were investigated by testing alkaline zinc/manganese dioxide cells of the type typically used in ELT's. Cells from four manufacturers were tested. The cells were subjected to simulated environmental and load conditions representative of those required for survival and operation. Battery cell characteristics that may contribute to ELT malfunctions and limitations were evaluated. Experimental results from the battery cell study are discussed, and an evaluation of ELT performance while operating under a representative worst-case environmental condition is presented
Binary Population and Spectral Synthesis Version 2.1: construction, observational verification and new results
The Binary Population and Spectral Synthesis (BPASS) suite of binary stellar
evolution models and synthetic stellar populations provides a framework for the
physically motivated analysis of both the integrated light from distant stellar
populations and the detailed properties of those nearby. We present a new
version 2.1 data release of these models, detailing the methodology by which
BPASS incorporates binary mass transfer and its effect on stellar evolution
pathways, as well as the construction of simple stellar populations. We
demonstrate key tests of the latest BPASS model suite demonstrating its ability
to reproduce the colours and derived properties of resolved stellar
populations, including well- constrained eclipsing binaries. We consider
observational constraints on the ratio of massive star types and the
distribution of stellar remnant masses. We describe the identification of
supernova progenitors in our models, and demonstrate a good agreement to the
properties of observed progenitors. We also test our models against photometric
and spectroscopic observations of unresolved stellar populations, both in the
local and distant Universe, finding that binary models provide a
self-consistent explanation for observed galaxy properties across a broad
redshift range. Finally, we carefully describe the limitations of our models,
and areas where we expect to see significant improvement in future versions.Comment: 69 pages, 45 figures. Accepted for publication in PASA. Accompanied
by a full, documented data release at http://bpass.auckland.ac.nz and
http://warwick.ac.uk/bpas
Bod1, a novel kinetochore protein required for chromosome biorientation
We have combined the proteomic analysis of Xenopus laevis in vitro–assembled chromosomes with RNA interference and live cell imaging in HeLa cells to identify novel factors required for proper chromosome segregation. The first of these is Bod1, a protein conserved throughout metazoans that associates with a large macromolecular complex and localizes with kinetochores and spindle poles during mitosis. Small interfering RNA depletion of Bod1 in HeLa cells produces elongated mitotic spindles with severe biorientation defects. Bod1-depleted cells form syntelic attachments that can oscillate and generate enough force to separate sister kinetochores, suggesting that microtubule–kinetochore interactions were intact. Releasing Bod1-depleted cells from a monastrol block increases the frequency of syntelic attachments and the number of cells displaying biorientation defects. Bod1 depletion does not affect the activity or localization of Aurora B but does cause mislocalization of the microtubule depolymerase mitotic centromere- associated kinesin and prevents its efficient phosphorylation by Aurora B. Therefore, Bod1 is a novel kinetochore protein that is required for the detection or resolution of syntelic attachments in mitotic spindles
Uncertainty in multitask learning: joint representations for probabilistic MR-only radiotherapy planning
Multi-task neural network architectures provide a mechanism that jointly
integrates information from distinct sources. It is ideal in the context of
MR-only radiotherapy planning as it can jointly regress a synthetic CT (synCT)
scan and segment organs-at-risk (OAR) from MRI. We propose a probabilistic
multi-task network that estimates: 1) intrinsic uncertainty through a
heteroscedastic noise model for spatially-adaptive task loss weighting and 2)
parameter uncertainty through approximate Bayesian inference. This allows
sampling of multiple segmentations and synCTs that share their network
representation. We test our model on prostate cancer scans and show that it
produces more accurate and consistent synCTs with a better estimation in the
variance of the errors, state of the art results in OAR segmentation and a
methodology for quality assurance in radiotherapy treatment planning.Comment: Early-accept at MICCAI 2018, 8 pages, 4 figure
Factors for Supporting Primary Care Physician Engagement With Patient Apps for Type 2 Diabetes Self-Management That Link to Primary Care: Interview Study.
BACKGROUND: The health burden of type 2 diabetes can be mitigated by engaging patients in two key aspects of diabetes care: self-management and regular contact with health professionals. There is a clear benefit to integrating these aspects of care into a single clinical tool, and as mobile phone ownership increases, apps become a more feasible platform. However, the effectiveness of online health interventions is contingent on uptake by health care providers, which is typically low. There has been little research that focuses specifically on barriers and facilitators to health care provider uptake for interventions that link self-management apps to the user's primary care physician (PCP). OBJECTIVE: This study aimed to explore PCP perspectives on proposed features for a self-management app for patients with diabetes that would link to primary care services. METHODS: Researchers conducted 25 semistructured interviews. The interviewer discussed potential features that would link in with the patient's primary care services. Interviews were audio-recorded, transcribed, and coded. Framework analysis and the Consolidated Criteria for Reporting Qualitative Research checklist were employed to ensure rigor. RESULTS: Our analysis indicated that PCP attitudes toward proposed features for an app were underpinned by perceived roles of (1) diabetes self-management, (2) face-to-face care, and (3) the anticipated burden of new technologies on their practice. Theme 1 explored PCP perceptions about how an app could foster patient independence for self-management behaviors but could also increase responsibility and liability for the PCP. Theme 2 identified beliefs underpinning a commonly expressed preference for face-to-face care. PCPs perceived information was more motivating, better understood, and presented with greater empathy when delivered face to face rather than online. Theme 3 described how most PCPs anticipated an initial increase in workload while they learned to use a new clinical tool. Some PCPs accepted this burden on the basis that the change was inevitable as health care became more integrated. Others reported potential benefits were outweighed by effort to implement an app. This study also identified how app features can be positively framed, highlighting potential benefits for PCPs to maximize PCP engagement, buy-in, and uptake. For example, PCPs were more positive when they perceived that an app could facilitate communication and motivation between consultations, focus on building capacity for patient independence, and reinforce rather than replace in-person care. They were also more positive about app features that were automated, integrated with existing software, flexible for different patients, and included secondary benefits such as improved documentation. CONCLUSIONS: This study provided insight into PCP perspectives on a diabetes app integrated with primary care services. This was observed as more than a technological change; PCPs were concerned about changes in workload, their role in self-management, and the nature of consultations. Our research highlighted potential facilitators and barriers to engaging PCPs in the implementation process
Re-evaluating Passive Research Involvement in the Undergraduate Curriculum
In recent years, advocates for research-based education have publicized many examples of passive research
involvement, defined as undergraduates learning about the
content and lived experience of research at their institution. But the qualitative dimensions of passive research
involvement remain unknown. The authors’ study uses
Diana Laurillard’s “conversational framework” to analyze
reports from 367 undergraduate students at a UK researchintensive university who met researchers and learned
about their work. The results show a range of experiences
in student learning about faculty research. These findings
make the case that passive research involvement has its
own integrity and cannot be characterized as an absence of
participation. The authors suggest ways that the students
as audience category can enhance undergraduate connections with research
Pseudorehearsal in value function approximation
Catastrophic forgetting is of special importance in reinforcement learning,
as the data distribution is generally non-stationary over time. We study and
compare several pseudorehearsal approaches for Q-learning with function
approximation in a pole balancing task. We have found that pseudorehearsal
seems to assist learning even in such very simple problems, given proper
initialization of the rehearsal parameters
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