1,786 research outputs found
Theory of selective excitation in Stimulated Raman Scattering
A semiclassical model is used to investigate the possibility of selectively
exciting one of two closely spaced, uncoupled Raman transitions. The duration
of the intense pump pulse that creates the Raman coherence is shorter than the
vibrational period of a molecule (impulsive regime of interaction). Pulse
shapes are found that provide either enhancement or suppression of particular
vibrational excitations.Comment: RevTeX4,10 pages, 5 figures, submitted to Phys.Rev.
Beable trajectories for revealing quantum control mechanisms
The dynamics induced while controlling quantum systems by optimally shaped
laser pulses have often been difficult to understand in detail. A method is
presented for quantifying the importance of specific sequences of quantum
transitions involved in the control process. The method is based on a
``beable'' formulation of quantum mechanics due to John Bell that rigorously
maps the quantum evolution onto an ensemble of stochastic trajectories over a
classical state space. Detailed mechanism identification is illustrated with a
model 7-level system. A general procedure is presented to extract mechanism
information directly from closed-loop control experiments. Application to
simulated experimental data for the model system proves robust with up to 25%
noise.Comment: Latex, 20 pages, 13 figure
Constitutive expression of Yes-associated protein (Yap) in adult skeletal muscle fibres induces muscle atrophy and myopathy
Peer reviewedPublisher PD
A randomised trial comparing combination chemotherapy using mitomycin C, mitozantrone and methotrexate (3M) with vincristine, anthracycline and cyclophosphamide (VAC) in advanced breast cancer.
This paper describes a randomised clinical trial in patients with advanced breast cancer, comparing the regimen 3M, mitomycin C 7-8 mg m-2 (day 1), mitozantrone 7-8 mg m-2 (day 1 and 21), methotrexate 35 mg m-2 (day 1 and 21) given on a 42 day cycle with a standard anthracycline containing regimen, VAC, vincristine 1.4 mg m-2 (day 1), anthracycline (adriamycin or epirubicin) 30 mg m-2 (day 1), cyclophosphamide 400 mg m-2 (day 1) given on a 21 day cycle. Of a total of 217 patients, 107 were randomised to 3M and 110 to VAC and a mean of 5.5 courses was given per patient. The overall response rate (complete and partial) was 53% (95% Confidence Limits (CL): 43-62%) for 3M and 49% (CL; 39-58%) for VAC. The response according to sites of metastases was the same for both treatment groups. Symptomatic toxicity including alopecia, neuropathy, vomiting (P less than 0.001) and nausea (P less than 0.01) were significantly less for 3M. Myelosuppression including leucopenia (P less than 0.001) and thrombocytopenia (P less than 0.001) was significantly greater with 3M at day 21, although there was no difference in nadir counts in patients at special risk of myelosuppression and there was no evidence of an increase in infective or bleeding complications. There was no significant difference in the duration of response to 3M (10 months, CL 6-15) and VAC (11 months, CL 7-12), nor in survival (3M, 8 months, CL 6-12; VAC, 10 months, CL 8-12). These results indicate that 3M is as effective as, but has significantly less symptomatic toxicity than, an anthracycline containing regimen for the treatment of advanced breast cancer
Response of \u3cem\u3eArachis pintoi\u3c/em\u3e to Grazing Intensity When Associated with Different Grasses
Lack of legume persistence is one of the main reasons for poor utilisation of grass-legume pastures in the tropics. Arachis pintoi (forage peanut) is currently the most promising forage legume for the humid tropics, mainly because of good persistence under grazing (Grof, 1985; Fisher & Cruz, 1995). The objective of this work was to show how two accessions of A. pintoi react to increasing herbage allowance levels when associated with two different grasses
A new technique for elucidating -decay schemes which involve daughter nuclei with very low energy excited states
A new technique of elucidating -decay schemes of isotopes with large
density of states at low excitation energies has been developed, in which a
Broad Energy Germanium (BEGe) detector is used in conjunction with coaxial
hyper-pure germanium detectors. The power of this technique has been
demonstrated on the example of 183Hg decay. Mass-separated samples of 183Hg
were produced by a deposition of the low-energy radioactive-ion beam delivered
by the ISOLDE facility at CERN. The excellent energy resolution of the BEGe
detector allowed rays energies to be determined with a precision of a
few tens of electronvolts, which was sufficient for the analysis of the
Rydberg-Ritz combinations in the level scheme. The timestamped structure of the
data was used for unambiguous separation of rays arising from the
decay of 183Hg from those due to the daughter decays
Observation of coherent transients in ultrashort chirped excitation of an undamped two-level system
The effects of Coherent excitation of a two level system with a linearly
chirped pulse are studied theoretically and experimentally (in Rb (5s - 5p)) in
the low field regime. The Coherent Transients are measured directly on the
excited state population on an ultrashort time scale. A sharp step corresponds
to the passage through resonance. It is followed by oscillations resulting from
interferences between off-resonant and resonant contributions. We finally show
the equivalence between this experiment and Fresnel diffraction by a sharp
edge.Comment: 4 pages, 4 figures, to appear in PR
Time Optimal Control in Spin Systems
In this paper, we study the design of pulse sequences for NMR spectroscopy as
a problem of time optimal control of the unitary propagator. Radio frequency
pulses are used in coherent spectroscopy to implement a unitary transfer of
state. Pulse sequences that accomplish a desired transfer should be as short as
possible in order to minimize the effects of relaxation and to optimize the
sensitivity of the experiments. Here, we give an analytical characterization of
such time optimal pulse sequences applicable to coherence transfer experiments
in multiple-spin systems. We have adopted a general mathematical formulation,
and present many of our results in this setting, mindful of the fact that new
structures in optimal pulse design are constantly arising. Moreover, the
general proofs are no more difficult than the specific problems of current
interest. From a general control theory perspective, the problems we want to
study have the following character. Suppose we are given a controllable right
invariant system on a compact Lie group, what is the minimum time required to
steer the system from some initial point to a specified final point? In NMR
spectroscopy and quantum computing, this translates to, what is the minimum
time required to produce a unitary propagator? We also give an analytical
characterization of maximum achievable transfer in a given time for the two
spin system.Comment: 20 Pages, 3 figure
Phase II trial of the oral platinum complex JM216 in non-small-cell lung cancer: An EORTC early clinical studies group investigation
Background JM216 is a new oral platinum complex with dose-limiting toxicity myelosuppresssion, now undergoing phase II evaluation. Patients and methods JM216 was evaluated as first line therapy in non-small-cell lung cancer. Seventeen patients received 120 mg/m2/day for five days repeated every three weeks. Results Toxicity was manageable, the commonest side-effects being nausea, vomiting, diarrhoea, constipation and asthenia. Myelososuppression was generally grade <2 and there were no cases of neutropenic sepsis or bleeding. Thirteen patients were fully evaluable for response. No sustained objective responses were reported. One patient was reported as stable disease had a partial response after three courses but was progressing again after four. An additional five patients had stable disease (46.2%). Conclusions Although some patients may have had useful palliation, JM216 did not appear to have significant antitumour activity in non-small-cell lung cance
Global geometry optimization of silicon clusters described by three empirical potentials
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