Physiological correlates of optimal performance Semiannual status report, 1 Dec. 1968 - 30 Apr. 1969

Physiological and psychological tests for determining optimum performanc

Anisotropic spin splitting and spin relaxation in asymmetric zinc-blende semiconductor quantum structures

Spin relaxation due to the D'yakonov-Perel' mechanism is intimately related with the spin splitting of the electronic states. We determine the spin relaxation rates from anisotropic spin splittings of electron subbands in n-(001) zinc-blende semiconductor quantum structures calculated self-consistently in the multi-band envelope function approach. The giant anisotropy of spin relaxation rates found for different spin-components in the (001) plane can be ascribed to the interplay between the bulk and quantum well inversion asymmetry. One of the in-plane relaxation rates may exhibit a striking nonmonotonous dependence on the carrier density.Comment: 6 pages, 7 figures; revised version with minor changes after refereein

Modification of primordial ices by cosmic rays as simulated by cyclotron irradiation

Frozen CH4 and CH4/Ar mixtures closed into metal cuvettes and open to the vacuum were irradiated at 15 and 77 K with 10 - 20 MeV p and He-3(2+) ions in order to simulate the effect of cosmic rays on solid organic matter in space. Ices exposed to vacuum represent surfaces of icy systems whereas closed systems stand for bulk ices. The products were analyzed by MS, SEM, RBS, ERDA, H-1-NMR, HPLC, GC-MS, NEXAFS, and FT-IR. Volatile products consisted of a mixture of low molecular species, e.g., C2H2, C2H4, C2H6, and long linear aliphatic and olefinic compounds. The formation of polycyclic aromatic hydrocarbons (PAH's) and related species in solid CH4 is due to a multi-center reaction within one collision cascade and is governed by energy density effects with critical linear energy transfer values L(sub T) between 2 and 10 keV/micron. Open ices exhibit preferential hydrogen release resulting in an increased carbonization as compared to more hydrogen rich molecules protected inside large icy bodies

Psychological and physiological correlates of stress: Performance on a cooperative task

The relationship of personality dimensions to performance was investigated. The personality measure used to select subjects, the Barratt impulsiveness scale, is hypothesized to be related to a style of behavior which should affect the trend of choices which various subjects will make. Personality dimensions were specifically examined during performance of a cooperative task, the Prisoner's Dilemma

Heart Rate Response to Sound and Light

Heart rate response to varying sound and light intensitie

Effect of weak disorder on the ground state of uniaxial dipolar spin systems in the upper critical dimension

Extensive Monte Carlo simulations are used to investigate the stability of the ferromagnetic ground state in three-dimensional systems of Ising dipoles with added quenched disorder. These systems model the collective ferromagnetic order observed in various systems with dipolar long-range interactions. The uniaxial dipolar spins are arranged on a face-centred cubic lattice with periodic boundary conditions. Finite-size scaling relations for the pure dipolar ferromagnetic system are derived by a renormalisation group calculation. These functions include logarithmic corrections to the expected mean field behaviour since the system is in its upper critical dimension. Scaled data confirm the validity of the finite-size scaling description and results are compared with subsequent analysis of weakly disordered systems. A disorder-temperature phase diagram displays the preservation of the ferromagnetic ground state with the addition of small amounts of disorder, suggesting the irrelevance of weak disorder in these systems.Comment: 6 pages, 4 figures; proceedings of the 3rd NEXT-Sigma-Phi Conference, Kolymbari, Greece, August 200

Physiological correlates of optimal performance

Analysis of psychological and physiological variables for predicting human performance during extended periods of stres

Handling and analysis of ices in cryostats and glove boxes in view of cometary samples

Comet nucleus sample return mission and other return missions from planets and satellites need equipment for handling and analysis of icy samples at low temperatures under vacuum or protective gas. Two methods are reported which were developed for analysis of small icy samples and which are modified for larger samples in cometary matter simulation experiments (KOSI). A conventional optical cryostat system was modified to allow for transport of samples at 5 K, ion beam irradiation, and measurement in an off-line optical spectrophotometer. The new system consists of a removable window plug containing nozzles for condensation of water and volatiles onto a cold finger. This plug can be removed in a vacuum system, changed against another plug (e.g., with other windows (IR, VIS, VUV) or other nozzles). While open, the samples can be treated under vacuum with cooling by manipulators (cut, removal, sample taking, irradiation with light, photons, or ions). After bringing the plug back, the samples can be moved to another site of analysis. For handling the 30 cm diameter mineral-ice samples from the KOSI experiments an 80x80x80 cm glove box made out of plexiglass was used. The samples were kept in a liquid nitrogen bath, which was filled from the outside. A stream a dry N2 and evaporating gas from the bath purified the glove box from impurity gases and, in particular, H2O, which otherwise would condense onto the samples

Prospective, open, multi-centre phase I/II trial to assess safety and efficacy of neoadjuvant radiochemotherapy with docetaxel and oxaliplatin in patients with adenocarcinoma of the oesophagogastric junction

Background: This phase I/II-trial assessed the dose-limiting toxicities (DLT) and maximum tolerated dose (MTD) of neoadjuvant radiochemotherapy (RCT) with docetaxel and oxaliplatin in patients with locally advanced adenocarcinoma of the oesophagogastric junction. Methods: Patients received neoadjuvant radiotherapy (50.4 Gy) together with weekly docetaxel (20 mg/m2 at dose level (DL) 1 and 2, 25 mg/m2 at DL 3) and oxaliplatin (40 mg/m2 at DL 1, 50 mg/m2 at DL 2 and 3) over 5 weeks. The primary endpoint was the DLT and the MTD of the RCT regimen. Secondary endpoints included overall response rate (ORR) and progression-free survival (PFS). Results: A total of 24 patients were included. Four patients were treated at DL 1, 13 patients at DL 2 and 7 patients at DL 3. The MTD of the RCT was considered DL 2 with docetaxel 20 mg/m2 and oxaliplatin 50 mg/m2. Objective response (CR/PR) was observed in 32% (7/22) of patients. Eighteen patients (75%) underwent surgery after RCT. The median PFS for all patients (n = 24) was 6.5 months. The median overall survival for all patients (n = 24) was 16.3 months. Patients treated at DL 2 had a median overall survival of 29.5 months. Conclusion: Neoadjuvant RCT with docetaxel 20 mg/m2 and oxaliplatin 50 mg/m2 was effective and showed a good toxicity profile. Future studies should consider the addition of targeted therapies to current neoadjuvant therapy regimens to further improve the outcome of patients with advanced cancer of the oesophagogastric junction. Trial Registration: NCT0037498