Absolute dimensions of the unevolved B-type eclipsing binary GG Orionis

We present photometric observations in B and V as well as spectroscopic observations of the detached, eccentric 6.6-day double-lined eclipsing binary GG Ori, a member of the Orion OB1 association. Absolute dimensions of the components, which are virtually identical, are determined to high accuracy (better than 1% in the masses and better than 2% in the radii) for the purpose of testing various aspects of theoretical modeling. We obtain M(A) = 2.342 +/- 0.016 solar masses and R(A) = 1.852 +/- 0.025 solar radii for the primary, and M(B) = 2.338 +/- 0.017 solar masses and R(B) = 1.830 +/- 0.025 solar radii for the secondary. The effective temperature of both stars is 9950 +/- 200 K, corresponding to a spectral type of B9.5. GG Ori is very close to the ZAMS, and comparison with current stellar evolution models gives ages of 65-82 Myr or 7.7 Myr depending on whether the system is considered to be burning hydrogen on the main sequence or still in the final stages of pre-main sequence contraction. We have detected apsidal motion in the binary at a rate of dw/dt = 0.00061 +/- 0.00025 degrees per cycle, corresponding to an apsidal period of U = 10700 +/- 4500 yr. A substantial fraction of this (approximately 70%) is due to the contribution from General Relativity.Comment: To appear in The Astronomical Journal, December 200

ЗНАЧЕНИЕ ПРЕСЕПСИНА КАК РАННЕГО МАРКЕРА ГНОЙНО- СЕПТИЧЕСКИХ ОСЛОЖНЕНИЙ У ПАЦИЕНТОВ С ТЯЖЕЛЫМ ПАНКРЕАТИТОМ

Sepsis is the leading cause of mortality in patients with severe acute pancreatitis (SAP). High mortality rate in patients with SAP is mainly associated with purulent and inflammatory process in parapancreatic fat. Early laboratory diagnosis of infection is vitally important for timely indications for surgery and successful therapy. Aim of study The comparison of prognostic and diagnostic values of presepsin and acute phase proteins (CRP, PCT) in the development of septic complications in patients with SAP at the early stage. Material and methods We examined 37 patients with SAP. Depending on the course and outcome of the disease, patients were divided into two groups: Group 1 (n=10) — deceased patients, Group 2 (n=27) — patients with a favorable outcome. Each of these groups was divided into two subgroups: 1A (n=8) — patients who died of sepsis, 1B (n=2) — patients who died of other causes, 2A (n=7) — patients with a favorable outcome of sepsis and 2B (n=20) — patients without septic complications. The PSEP level was measured with PATHFAST enzyme immunoassay analyzer (LSI Medience Corporation, Japan). Descriptive statistics of quantitative characteristics were represented by medians and quartiles (Me (LQ; UQ)), values of area under the ROC curve (AUC) and 95% confidence interval. To compare the groups, the Mann–Whitney U test was used. Results The concentration of PSEP 785 pg/ml and higher on day 2–5 from the onset of the disease indicated a significant risk of purulent complications in intensive care patients with a sensitivity of 91.2% (95% CI, 77.93–97.89) and a specificity of 77.3% (95% CI, 51.59–97.91). The area under the curve for PSEP was 0.859 (AUC). PCT — 0.804 (AUC), sensitivity — 85%, specificity — 57%. CRP — 0.718 (AUC), sensitivity — 75% and specificity — 50%. Conclusion Based on the data obtained, it can be concluded that PSEP has the most informative value and diagnostic sensitivity compared to other markers of inflammation for an early diagnosis of sepsis in patients with SAP.Сепсис является основной причиной летальных исходов у пациентов с тяжёлым острым панкреатитом (ТОП). Высокая летальность при остром панкреатите обусловлена, в основном, гнойно-вос- палительными процессами в парапанкреатической клетчатке. Ранняя лабораторная диагностика инфицирования является крайне важной для своевременного определения показаний к хирургическим вмешательствам и залогом успешного лечения пациентов с ТОП. Цель исследования Сравнительный анализ прогностической и диагностической значимости уровня PSEP и белков острой фазы (С-реактивный белок (CRP), прокальцитонин (РСТ)) при формировании гнойно-сеп- тических осложнений у пациентов с ТОП на ранней стадии. Материал и методы Обследовано 37 пациентов с диагнозом ТОП. В зависимости от течения и исхода заболевания пациентов разделили на две группы: 1 гр. (n=10) — умершие пациенты, 2 гр. (n=27) — пациенты с благоприятным исходом. Каждая из этих групп разделена на две подгруппы: 1А гр. (n=8) составили пациенты, умершие от сепсиса, 1В гр. (n=2) — пациенты, умершие от других причин, 2А гр. (n=7) — пациенты с благоприятным исходом сепсиса и, 2В гр. (n=20) — пациенты без септических осложнений. Определение уровня пресепсина (PSEP) выполняли на иммуноферментном анализаторе PATHFAST (LSI Medience corporation, Япония). Описательная статистика количественных признаков представлена медианами и квартилями (Me (LQ; UQ)), значениями площади под ROC-кривой (AUC) и 95% доверительным интервалом. Для сравнения групп применяли U-критерий Манна–Уитни. Результаты Концентрация PSEP 785 пг/мл и выше на 2–5-е сут от начала заболевания указывала на значительный риск гнойных осложнений у пациентов отделений интенсивной терапии с чувствительностью 91,2% (95%Cl, 77,93–97,89) и специфичностью 77,3% (95%Cl, 51,59–97,91). Площадь под кривой для PSEP — 0,859 (AUC). РСТ — 0,804 (AUC), чувствительность — 85%, специфичность — 57%. СRP — 0,718 (AUC), чувствительность 75% и специфичность 50%. Заключение На основании полученных данных можно заключить, что наибольшей информативной значимостью и диагностической чувствительностью, по сравнению с другими маркёрами воспаления, для ранней диагностики сепсиса у пациентов с ТОП обладает PSEP

Environmental factors in a population-based inception cohort of inflammatory bowel disease patients in Europe--an ECCO-EpiCom study.

To access publisher's full text version of this article click on the hyperlink at the bottom of the pageThe incidence of inflammatory bowel disease (IBD) is increasing in Eastern Europe possibly due to changes in environmental factors towards a more "westernised" standard of living. The aim of this study was to investigate differences in exposure to environmental factors prior to diagnosis in Eastern and Western European IBD patients.The EpiCom cohort is a population-based, prospective inception cohort of 1560 unselected IBD patients from 31 European countries covering a background population of 10.1 million. At the time of diagnosis patients were asked to complete an 87-item questionnaire concerning environmental factors.A total of 1182 patients (76%) answered the questionnaire, 444 (38%) had Crohn's disease (CD), 627 (53%) ulcerative colitis (UC), and 111 (9%) IBD unclassified. No geographic differences regarding smoking status, caffeine intake, use of oral contraceptives, or number of first-degree relatives with IBD were found. Sugar intake was higher in CD and UC patients from Eastern Europe than in Western Europe while fibre intake was lower (p<0.01). Daily consumption of fast food as well as appendectomy before the age of 20 was more frequent in Eastern European than in Western European UC patients (p<0.01). Eastern European CD and UC patients had received more vaccinations and experienced fewer childhood infections than Western European patients (p<0.01).In this European population-based inception cohort of unselected IBD patients, Eastern and Western European patients differed in environmental factors prior to diagnosis. Eastern European patients exhibited higher occurrences of suspected risk factors for IBD included in the Western lifestyle.Danish Colitis Crohn Patients Organisation (CCF) Vibeke Binder and Povl Riis Foundation Scientific Council at Herlev Hospital Sigrid Rignnor Moran Foundation, Aage and Johanne Louis-Hansens Foundation Munkholm Foundation C.C. Klestrup and Henriette Klestrup Foundation Knud and Dagny Gad Andresens Foundation Else and Mogens Wedell-Wedellsborgs Foundation Direktor Jacob Madsen and Olga Madsen's Foundation, Scan Ve

OUTPATIENT REGISTER OF CARDIOVASCULAR DISEASES IN THE RYAZAN REGION (RECVASA): PRINCIPAL TASKS, EXPERIENCE OF DEVELOPMENT AND FIRST RESULTS

Aim. To estimate risk factors and comorbidity structure, cardiovascular diseases outcomes, evaluate their diagnostics and treatment quality in real outpatient practice using a register of patients with arterial hypertension (HT), ischemic heart disease (IHD), chronic heart failure (CHF) and atrial fibrillation (AF) in the Ryazan Region – the territorial subject ofRussian Federation with high cardiovascular mortality rate.Material and methods. The total of 1000 HT, IHD, CHF, AF patients, applied for general practitioners or cardiologists of theRyazan outpatient clinics in March-May of 2012 were sequentially enrolled in the outpatient REgister of CardioVAscular diseases (RECVASA).Results. According to outpatient cards data HT, IHD, CHF and AF were diagnosed in 99.0%; 70.9%; 74.8% and 13.7% of the 1000 cases, respectively. 820 (82%) patients revealed a concomitant cardiovascular pathology (cardiac comorbidity), at that the most frequent was combination of HT with IHD and CHF (50.4%). Diabetes mellitus was diagnosed in 209 (20.9%) patients. 770 (77%) patients were assessed on their total cholesterol level; smoking status and family history of heart diseases were estimated in 28 (2.8%) and 49 (4.9%) patients, respectively. Exercise tolerance test (stress-test) was carried out in 2% of the patients (including 2.8% of the IHD patients), 24-hour blood pressure (BP) and ECG monitoring – in 0.7% and 5.5%, respectively; echocardiography and ultrasound of brachiocephalic arteries (BCA) – in 25.6% and 8.6%, respectively; coronary angiography – in 1.6% (which includes 2.3% of the IHD patients). The following drug groups were prescribed most frequently: antiplatelet agents – in 60.4% of the cases (584 patients received acetylsalicylic acid and 20 – clopidogrel), ACE inhibitors – in 62.9%, β-blockers – in 43.9% of the patients. Target BP level was achieved in 245 of 956 cases (25.6%). 50.6% of IHD patients and 51.1% of hypercholesterolemic patients received statins.Conclusion. The pilot stage of the RECVASA study revealed a high incidence rate of cardiac comorbidity (82%) in patients with hypertension, IHD, CHF and AF, insufficient estimation of cardiovascular risk factors, inadequate frequency of stress-tests, 24-hour BP and ECG monitoring, echocardiography, BCA sonography, coronary angiography use, as well as a scarce prescription of warfarin in AF and statins in hypercholesterolemic patients. Improvement of correspondence to national guidelines is the main reserve for enhancement of diagnostics and treatment quality in patients with HT, IHD, CHF, AF and hypercholesterolemia

Natural Disease Course of Ulcerative Colitis During the First Five Years of Follow-up in a European Population-based Inception Cohort-An Epi-IBD Study

International audienceBackground and Aims: Few population-based cohort studies have assessed the disease course of ulcerative colitis [UC] in the era of biological therapy and widespread use of immunomodulators. The aim of this study was to assess the 5-year outcome and disease course of patients with UC in the Epi-IBD cohort. Methods: In a prospective, population-based inception cohort of unselected patients with UC, patients were followed up from the time of their diagnosis, which included the collection of their clinical data, demographics, disease activity, medical therapy, and rates of surgery, cancers, and deaths. Associations between outcomes and multiple covariates were analysed by Cox regression analysis. Results: A total of 717 patients were included in the study. During follow-up, 43 [6%] patients underwent a colectomy and 163 [23%] patients were hospitalised. Of patients with limited colitis [distal to the left flexure], 90 [21%] progressed to extensive colitis. In addition, 92 [27%] patients with extensive colitis experienced a regression in disease extent, which was associated with a reduced risk of hospitalisation (hazard ratio [HR]: 0.5 95% CI: 0.3-0.8]. Overall, patients were treated similarly in both geographical regions; 80 [11%] patients needed biological therapy and 210 [29%] patients received immunomodulators. Treatment with immunomodulators was found to reduce the risk of hospitalisation [HR: 0.5 95% CI: 0.3-0.8]. Conclusions: Although patients in this population-based cohort were treated more aggressively with immunomodulators and biological therapy than in cohorts from the previous two decades, their disease outcomes, including colectomy rates, were no different. However, treatment with immunomodulators was found to reduce the risk of hospitalisation

Особенности иммунного дисбаланса при различных клинико-патогенетических вариантах остропрогрессирующего туберкулеза легких

In article the data, concerning features of cellular composition, proliferative activity and cytokines production of peripheral blood lymphocytes is presented in patients with various clinico-pathogenetic variants of pulmonary tuberculosis: drag-sensitive and drug-resistant infiltrative, disseminated, fibrous-cavernous. It is established that the extensive destructive tuberculosis without dependence from the clinical form of disease is accompanied by the expressed insufficiency of the cellular-mediated mechanisms of immunological resistance both to drag-sensitive, and to drug-resistant M. tuberculosis against quantitative prevalence of B-lymphocytes and intensity of their functional activity.Представлены данные, касающиеся особенностей клеточного состава, пролиферативной и цитокинпродуцирующей активности лимфоцитов периферической крови у больных с различными клинико-патогенетическими вариантами туберкулеза легких: лекарственно-чувствительным и лекарственно-устойчивым инфильтративным, диссеминированным, фиброзно-кавернозным. Установлено, что распространенный деструктивный туберкулез легких вне зависимости от клинической формы заболевания сопровождается выраженной недостаточностью клеточно-опосредованных механизмов иммунологической резистентности как к лекарственно-чувствительным, так и к лекарственно-резистентным M. tuberculosis на фоне количественного преобладания В-лимфоцитов и напряженности их функциональной активности

Hypertension control during the COVID-19 pandemic: results of the MMM2021 in Russia

Repetitive quarantines and social restrictions during the coronavirus disease 2019 (COVID-19) pandemic have negatively affected the population health in general, and the control of hypertension (HTN) in particular.Aim. To evaluate the control of HTN in the Russian population during the COVID-19 period based on the results of screening for HTN May Measurement Month 2021 (MMM2021).Material and methods. During May-August 2021, 2491 participants from 11 Russian regions took part in the screening. Participation was voluntary without restrictions on sex. All participants were over 18 years of age. During the screening, blood pressure (BP) was measured three times using automatic and mechanical BP monitors. In addition, a questionnaire was filled out on behavioral risk factors, comorbidities and therapy. HTN was diagnosed with systolic BP ≥140 mmHg and/ or diastolic blood pressure ≥90 mmHg and/or taking antihypertensive therapy. The questionnaire included questions about prior COVID-19, vaccinations and their impact on the intake of antihypertensive drugs.Results. The analysis included data from 2461 respondents aged 18 to 92, of which 963 were men (39,1%). The proportion of hypertensive patients was 41,0%, while among them 59,0% took antihypertensives and 30,9% were effectively treated. In comparison with pre-pandemic period according to MMM2018-2019, the higher proportion of HTN patients in the Russian sample was revealed during MMM2021 (41,0% vs 31,3%, p&lt;0,001) with a comparable proportion of patients receiving antihypertensive therapy (60,7% vs 59,0%, p=0,05) and treatment efficacy (28,7% vs 30,9%, p=0,36). Monotherapy was received in 44,7% of cases, while dual and triple combination therapy — in 30,9% and 14,1%, respectively. The majority of respondents (~90%) did not adjust their antihypertensive therapy during the COVID-19 pandemic.Conclusion. According to HTN screening in Russia, there is persistent ineffective control of HTN, which may be due to both the worsening pattern of behavioral risk factors, limited access to healthcare during COVID-19, and the inertia of physicians and low adherence of patients due to the asymptomatic HTN course in the majority

Методичні рекомендації

Методичні рекомендації щодо особливостей досудового розслідування кримінальних проваджень стосовно застосування примусових заходів медичного характеру / Грищенко О. В., Юхно О. О., Даниленко А. В. // Законодавче забезпечення правоохоронної діяльності : навч. посіб. / за заг. ред. В. В. Сокуренка. – Харків : Стильна типографія, 2017. – С. 367-387.Надано методичні рекомендації щодо особливостей досудового розслідування кримінальних проваджень стосовно застосування примусових заходів медичного характеру.Methodical recommendations on the peculiarities of pre-trial investigation of criminal proceedings concerning the application of coercive measures of a medical nature are provided.Даны методические рекомендации по особенностям досудебного расследования уголовных производств по применению принудительных мер медицинского характера

2020 Clinical practice guidelines for Myocarditis in adults

Russian Society of Cardiology (RSC)With the participation: Eurasian Association of Therapists (EUAT), Society of Specialists in Heart Failure (OSSN), Russian Scientific Medical Society of Therapists (RNMOT), Russian Society of Pathologists, Russian Society of Radiologists and Radiologists (RSR)Endorsed by: Research and Practical Council of the Ministry of Health of the Russian Federatio