Microkelvin thermometry with Bose-Einstein condensates of magnons and applications to studies of the AB interface in superfluid 3^3He

Coherent precession of trapped Bose-Einstein condensates of magnons is a sensitive probe for magnetic relaxation processes in superfluid 3He-B down to the lowest achievable temperatures. We use the dependence of the relaxation rate on the density of thermal quasiparticles to implement thermometry in 3He-B at temperatures below 300 $\mu$K. Unlike popular vibrating wire or quartz tuning fork based thermometers, magnon condensates allow for contactless temperature measurement and make possible an independent in situ determination of the residual zero-temperature relaxation provided by the radiation damping. We use this magnon-condensate-based thermometry to study the thermal impedance of the interface between A and B phases of superfluid 3He. The magnon condensate is also a sensitive probe of the orbital order-parameter texture. This has allowed us to observe for the first time the non-thermal signature of the annihilation of two AB interfaces.Comment: 26 pages, 7 figures, manuscript prepared for EU Microkelvin Collaboration Workshop 2013. Accepted for publication in Journal of Low Temperature Physic

APRIL:TACI axis is dispensable for the immune response to rabies vaccination.

There is significant need to develop a single-dose rabies vaccine to replace the current multi-dose rabies vaccine regimen and eliminate the requirement for rabies immune globulin in post-exposure settings. To accomplish this goal, rabies virus (RABV)-based vaccines must rapidly activate B cells to secrete antibodies which neutralize pathogenic RABV before it enters the CNS. Increased understanding of how B cells effectively respond to RABV-based vaccines may improve efforts to simplify post-exposure prophylaxis (PEP) regimens. Several studies have successfully employed the TNF family cytokine a proliferation-inducing ligand (APRIL) as a vaccine adjuvant. APRIL binds to the receptors TACI and B cell maturation antigen (BCMA)-expressed by B cells in various stages of maturation-with high affinity. We discovered that RABV-infected primary murine B cells upregulate APRIL ex vivo. Cytokines present at the time of antigen exposure affect the outcome of vaccination by influencing T and B cell activation and GC formation. Therefore, we hypothesized that the presence of APRIL at the time of RABV-based vaccine antigen exposure would support the generation of protective antibodies against RABV glycoprotein (G). In an effort to improve the response to RABV vaccination, we constructed and characterized a live recombinant RABV-based vaccine vector which expresses murine APRIL (rRABV-APRIL). Immunogenicity testing in mice demonstrated that expressing APRIL from the RABV genome does not impact the primary antibody response against RABV G compared to RABV alone. In order to evaluate the necessity of APRIL for the response to rabies vaccination, we compared the responses of APRIL-deficient and wild-type mice to immunization with rRABV. APRIL deficiency does not affect the primary antibody response to vaccination. Furthermore, APRIL expression by the vaccine did not improve the generation of long-lived antibody-secreting plasma cells (PCs) as serum antibody levels were equivalent in response to rRABV-APRIL and the vector eight weeks after immunization. Moreover, APRIL is dispensable for the long-lived antibody-secreting PC response to rRABV vaccination as anti-RABV G IgG levels were similar in APRIL-deficient and wild-type mice six months after vaccination. Mice lacking the APRIL receptor TACI demonstrated primary anti-RABV G antibody responses similar to wild-type mice following immunization with the vaccine vector indicating that this response is independent of TACI-mediated signals. Collectively, our findings demonstrate that APRIL and associated TACI signaling is dispensable for the immune response to RABV-based vaccination

Estimation of Kalman filter model parameters from an ensemble of tests

A methodology for estimating initial mean and covariance parameters in a Kalman filter model from an ensemble of nonidentical tests is presented. In addition, the problem of estimating time constants and process noise levels is addressed. Practical problems such as developing and validating inertial instrument error models from laboratory test data or developing error models of individual phases of a test are generally considered

Turbulent drag on a low-frequency vibrating grid in superfluid He-4 at very low temperatures

We present measurements of the dissipative turbulent drag on a vibrating grid in superfluid He-4 over a wide range of (low) frequencies. At high velocities, the dissipative drag is independent of frequency and is approximately the same as that measured in normal liquid He-4. We present measurements on a similar grid in superfluid He-3-B at low temperatures which shows an almost identical turbulent drag coefficient at low frequencies. However, the turbulent drag in He-3-B is substantially higher at higher frequencies. We also present measurements of the inertial drag coefficient for grid turbulence in He-4. The inertial drag coefficient is significantly reduced by turbulence in both superfluid and normal liquid He-4

Nanoelectronic thermometers optimised for sub-10 millikelvin operation

We report the cooling of electrons in nanoelectronic Coulomb blockade thermometers below 4 mK. Above 7 mK the devices are in good thermal contact with the environment, well isolated from electrical noise, and not susceptible to self-heating. This is attributed to an optimised design that incorporates cooling fins with a high electron-phonon coupling and on-chip electronic filters, combined with a low-noise electronic measurement setup. Below 7 mK the electron temperature is seen to diverge from the ambient temperature. By immersing a Coulomb Blockade Thermometer in the 3He/4He refrigerant of a dilution refrigerator, we measure a lowest electron temperature of 3.7 mK.Comment: 11 pages, 4 figures. (Fixed fitted saturation T_e on p9

Orbital damping of the oscillating superfluid He A-B interface at low temperatures

We present a model for the friction and effective mass of an oscillating superfluid He A-B interface due to orbital viscosity in the B-phase texture close to the interface. The model is applied to an experiment in which the A-B interface was stabilised in a magnetic field gradient at the transition field mT at 0 bar pressure and at a very low temperature mK. The interface was then oscillated by applying a small additional field at frequencies in the range 0.1-100 Hz. The response of the interface is governed by friction and by its effective mass. The measured dissipation does not fit theoretical predictions based either on the Andreev scattering of thermal quasiparticles or by pair-breaking from the moving interface. We describe a new mechanism based on the redistribution of thermal quasiparticle excitations in the B-phase texture engendered by the moving interface. This gives rise to friction via orbital viscosity and generates a significant effective mass of the interface. We have incorporated this mechanism into a simple preliminary model which provides reasonable agreement with the measured behaviour

Predictors of Negative Outcomes and Causes of Loss to Follow Up Among Breast Cancer Patients in Port-au-Prince, Haiti

Objective: To determine predictors of negative outcomes and causes of loss to follow-up (LTFU) in patients with breast cancer in Haiti. Design and Methods: Patients seen by Innovating Health International’s (IHI) cancer program were designated as LTFU after at least six months of non-contact (n=606). A cohort of LTFU breast cancer patients (n=101) was compared to the larger population of breast cancer patients (n=939), and a regression model constructed in order to identify risks for death and LTFU. Multiple calls were made to contact LTFU patients, and reasons for LTFU were recorded. Results: Death and LTFU status were associated with advanced stage (p\u3c0.0005), higher ECOG (p=0.011), and longer care (p\u3c0.0005; p=.03); LTFU status was lower with positive family history (p=0.022). 42.7% of LFTU patients were successfully contacted and 37.9% of these were reported deceased. The most common reasons for LTFU to clinic were obtaining care elsewhere and difficulty accessing care (due to distance, unrest, and money). Conclusions: Understanding causes of LTFU can suggest measures to reduce risk. LTFU was driven by the same factors as mortality, suggesting many “lost” patients may be deceased; this conclusion is furthermore supported by the low rate of successful recontact and high rate of death in the LTFU population. These conclusions support the need for improved palliative care outreach. Furthermore, LTFU status in Haiti is in part due to difficulties accessing care due to issues of politics, infrastructure, and economics