6,044 research outputs found
Investigating people: a qualitative analysis of the search behaviours of open-source intelligence analysts
The Internet and the World Wide Web have become integral parts of the lives of many modern individuals, enabling almost instantaneous communication, sharing and broadcasting of thoughts, feelings and opinions. Much of this information is publicly facing, and as such, it can be utilised in a multitude of online investigations, ranging from employee vetting and credit checking to counter-terrorism and fraud prevention/detection. However, the search needs and behaviours of these investigators are not well documented in the literature. In order to address this gap, an in-depth qualitative study was carried out in cooperation with a leading investigation company. The research contribution is an initial identification of Open-Source Intelligence investigator search behaviours, the procedures and practices that they undertake, along with an overview of the difficulties and challenges that they encounter as part of their domain. This lays the foundation for future research in to the varied domain of Open-Source Intelligence gathering
Systematic review of antimicrobial drug prescribing in hospitals.
Prudent antibiotic prescribing to hospital inpatients has the potential to reduce the incidences of antimicrobial resistance and healthcare-associated infection. We reviewed the literature from January 1980 to November 2003 to identify rigorous evaluations of interventions to improve hospital antibiotic prescribing. We identified 66 studies with interpretable data of which 16 reported 20 microbiological outcomes: Gram negative resistant bacteria (GNRB), 10 studies; Clostridium difficile associated diarrhoea (CDAD), 5 studies; vancomycin resistant enterococci (VRE), 3 studies and methicillin resistant Staphylococcus aureus (MRSA), 2 studies. Four studies provide good evidence that the intervention changed microbial outcomes with low risk of alternative explanations, eight studies provide less convincing evidence and four studies were negative. The strongest and most consistent evidence was for CDAD but we were able to analyse only the immediate impact of interventions because of nonstandardised durations of follow up. The ability to compare results of studies could be substantially improved by standardising methodology and reporting
Universal Baxterization for -graded Hopf algebras
We present a method for Baxterizing solutions of the constant Yang-Baxter
equation associated with -graded Hopf algebras. To demonstrate the
approach, we provide examples for the Taft algebras and the quantum group
.Comment: 8 page
The elements of a computational infrastructure for social simulation
Applications of simulation modelling in social science domains are varied and increasingly widespread. The effective deployment of simulation models depends on access to diverse datasets, the use of analysis capabilities, the ability to visualize model outcomes and to capture, share and re-use simulations as evidence in research and policy-making. We describe three applications of e-social science that promote social simulation modelling, data management and visualization. An example is outlined in which the three components are brought together in a transport planning context. We discuss opportunities and benefits for the combination of these and other components into an e-infrastructure for social simulation and review recent progress towards the establishment of such an infrastructure
The Solar Neighborhood XXV: Discovery of New Proper Motion Stars with 0.40 "/yr > mu > 0.18 "/yr between Declinations -47 degrees and 00 degrees
We present 2817 new southern proper motion systems with 0.40 "/yr > mu > 0.18
"/yr and declination between -47 degrees and 00 degrees. This is a continuation
of the SuperCOSMOS-RECONS (SCR) proper motion searches of the southern sky. We
use the same photometric relations as previous searches to provide distance
estimates based on the assumption that the objects are single main sequence
stars. We find 79 new red dwarf systems predicted to be within 25 pc, including
a few new components of previously known systems. Two systems - SCR 1731-2452
at 9.5 pc and SCR 1746-3214 at 9.9 pc - are anticipated to be within 10 pc. We
also find 23 new white dwarf candidates with distance estimates of 15-66 pc, as
well as 360 new red subdwarf candidates. With this search, we complete the SCR
sweep of the southern sky for stars with mu > 0.18 "/yr and R_59F < 16.5,
resulting in a total of 5042 objects in 4724 previously unreported proper
motion systems. Here we provide selected comprehensive lists from our SCR
proper motion search to date, including 152 red dwarf systems estimated to be
within 25 pc (nine within 10 pc), 46 white dwarfs (ten within 25 pc), and 598
subdwarf candidates. The results of this search suggest that there are more
nearby systems to be found at fainter magnitudes and lower proper motion limits
than those probed so far.Comment: 47 pages, 16 of text. 7 figure
Non-Perturbative One-Loop Effective Action for Electrodynamics in Curved Spacetime
In this paper we explicitly evaluate the one-loop effective action in four
dimensions for scalar and spinor fields under the influence of a strong,
covariantly constant, magnetic field in curved spacetime. In the framework of
zeta function regularization, we find the one-loop effective action to all
orders in the magnetic field up to linear terms in the Riemannian curvature. As
a particular case, we also obtain the one-loop effective action for massless
scalar and spinor fields. In this setting, we found that the vacuum energy of
charged spinors with small mass becomes very large due entirely by the
gravitational correction.Comment: LaTeX, 23 page
The Solar Neighborhood XXVII: Discovery of New Proper Motion Stars with mu > 0.18 "/yr in the Southern Sky with 16.5 > R_59F > 18.0
Here we present 1584 new southern proper motion systems with mu > 0.18 "/yr
and 16.5 > R_59F > 18.0. This search complements the six previous
SuperCOSMOS-RECONS (SCR) proper motion searches of the southern sky for stars
within the same proper motion range, but with R_59F < 16.5. As in previous
papers, we present distance estimates for these systems and find that three
systems are estimated to be within 25 pc, including one, SCR 1546-5534,
possibly within the RECONS 10 pc horizon at 6.7 pc, making it the second
nearest discovery of the searches. We find 97 white dwarf candidates with
distance estimates between 10 and 120 pc, as well as 557 cool subdwarf
candidates. The subdwarfs found in this paper make up nearly half of the
subdwarf systems reported from our SCR searches, and are significantly redder
than those discovered thus far. The SCR searches have now found 155 red dwarfs
estimated to be within 25 pc, including 10 within 10 pc. In addition, 143 white
dwarf candidates and 1155 cool subdwarf candidates have been discovered. The
1584 systems reported here augment the sample of 4724 systems previously
discovered in our SCR searches, and imply that additional systems fainter than
R_59F = 18.0 are yet to be discovered.Comment: 11 pages of text, seven figure
Femtosecond pulse generation in passively mode locked InAs quantum dot lasers
Optical pulse durations of an InAs two-section passively mode-locked quantum dot laser with a proton bombarded absorber section reduce from 8.4 ps at 250K to 290 fs at 20 K, a factor of 29, with a corresponding increase in optical bandwidth. Rate equation analysis of gain and emission spectra using rate equations suggests this is due to the very low emission rate of carriers to the wetting layer in the low temperature, random population regime which enables dots across the whole inhomogeneous distribution to act as independent oscillators. (C) 2013 AIP Publishing LLC
Hawaii Clean Energy Initiative (HCEI) Scenario Analysis: Quantitative Estimates Used to Facilitate Working Group Discussions (2008-2010)
This report provides details on the Hawaii Clean Energy Initiative (HCEI) Scenario Analysis to identify potential policy options and evaluate their impact on reaching the 70% HECI goal, present possible pathways to attain the goal based on currently available technology, with an eye to initiatives under way in Hawaii, and provide an 'order-of-magnitude' cost estimate and a jump-start to action that would be adjusted with a better understanding of the technologies and market
Using automated imaging to interrogate gonadotrophin-releasing hormone receptor trafficking and function
Gonadotrophin-releasing hormone (GnRH) acts via seven transmembrane receptors on gonadotrophs to stimulate gonadotrophin synthesis and secretion, and thereby mediates central control of reproduction. Type I mammalian GnRHR are unique, in that they lack C-terminal tails. This is thought to underlie their resistance to rapid homologous desensitisation as well as their slow rate of internalisation and inability to provoke G-protein-independent (arrestin-mediated) signalling. More recently it has been discovered that the vast majority of human GnRHR are actually intracellular, in spite of the fact that they are activated at the cell surface by a membrane impermeant peptide hormone. This apparently reflects inefficient exit from the endoplasmic reticulum and again, the absence of the C-tail likely contributes to their intracellular localisation. This review is intended to cover some of these novel aspects of GnRHR biology, focusing on ways that we have used automated fluorescence microscopy (high content imaging) to explore GnRHR localisation and trafficking as well as spatial and temporal aspects of GnRH signalling via the Ca(2+)/calmodulin/calcineurin/NFAT and Raf/MEK/ERK pathways
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