791 research outputs found
Degree of explanation
Partial explanations are everywhere. That is, explanations citing causes that explain some but not all of an effect are ubiquitous across science, and these in turn rely on the notion of degree of explanation. I argue that current accounts are seriously deficient. In particular, they do not incorporate adequately the way in which a causeās explanatory importance varies with choice of explanandum. Using influential recent contrastive theories, I develop quantitative definitions that remedy this lacuna, and relate it to existing measures of degree of causation. Among other things, this reveals the precise role here of chance, as well as bearing on the relation between causal explanation and causation itself
It's just a feeling: why economic models do not explain
Julian Reiss correctly identified a trilemma about economic models: we cannot maintain that they are false, but nevertheless explain and that only true accounts explain. In this reply we give reasons to reject the second premise ā that economic models explain. Intuitions to the contrary should be distrusted
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Psychological distress after stroke and aphasia: the first six months
Objective: We explored the factors that predicted psychological distress in the first six months post stroke in a sample including people with aphasia.
Design: Prospective longitudinal observational study.
Setting and subjects: Participants with a first stroke from two acute stroke units were assessed while still in hospital (baseline) and at three and six months post stroke.
Main measures: Distress was assessed with the General Health Questionnaire-12. Other measures included: NIH Stroke Scale, Barthel Index, Frenchay Aphasia Screening Test, Frenchay Activities Index, MOS Social Support Scale and social network indicators. Logistic regression was used to identify predictors of distress at each stage post stroke; and to determine what baseline factors predicted distress at six months.
Results: Eighty-seven participants were able to self-report on measures used, of whom 32 (37%) had aphasia. 71 (82%) were seen at six months, including 11 (16%) with aphasia. Predictors of distress were: stroke severity at baseline; low social support at three months; and loneliness and low satisfaction with social network at six months. The baseline factors that predicted distress at six months were psychological distress, loneliness and low satisfaction with social network (Nagelkerke R2 = 0.49). Aphasia was not a predictor of distress at any time point. Yet, at three months post stroke 93% of those with aphasia experienced high distress, as opposed to 50% of those without aphasia (Ļ2 (1) = 8.61, P<0.01).
Conclusions: Factors contributing to distress after stroke vary across time. Loneliness and low satisfaction with oneās social network are particularly important and contribute to long-term psychological distress
The visual orbits of the spectroscopic binaries HD 6118 and HD 27483 from the Palomar Testbed Interferometer
We present optical interferometric observations of two double-lined
spectroscopic binaries, HD 6118 and HD 27483, taken with the Palomar Testbed
Interferometer (PTI) in the K band. HD 6118 is one of the most eccentric
spectroscopic binaries and HD 27483 a spectroscopic binary in the Hyades open
cluster. The data collected with PTI in 2001-2002 allow us to determine
astrometric orbits and when combined with the radial velocity measurements
derive all physical parameters of the systems. The masses of the components are
2.65 +/- 0.27 M_Sun and 2.36 +/- 0.24 M_Sun for HD 6118 and 1.38 +/- 0.13 M_Sun
and 1.39 +/- 0.13 M_Sun for HD 27483. The apparent semi-major axis of HD 27483
is only 1.2 mas making it the closest binary successfully observed with an
optical interferometer.Comment: submitted to Ap
Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples
The diagnosis of medulloblastoma likely encompasses several distinct entities, with recent evidence for the existence of at least four unique molecular subgroups that exhibit distinct genetic, transcriptional, demographic, and clinical features. Assignment of molecular subgroup through routine profiling of high-quality RNA on expression microarrays is likely impractical in the clinical setting. The planning and execution of medulloblastoma clinical trials that stratify by subgroup, or which are targeted to a specific subgroup requires technologies that can be economically, rapidly, reliably, and reproducibly applied to formalin-fixed paraffin embedded (FFPE) specimens. In the current study, we have developed an assay that accurately measures the expression level of 22 medulloblastoma subgroup-specific signature genes (CodeSet) using nanoString nCounter Technology. Comparison of the nanoString assay with Affymetrix expression array data on a training series of 101 medulloblastomas of known subgroup demonstrated a high concordance (Pearson correlation rĀ =Ā 0.86). The assay was validated on a second set of 130 non-overlapping medulloblastomas of known subgroup, correctly assigning 98% (127/130) of tumors to the appropriate subgroup. Reproducibility was demonstrated by repeating the assay in three independent laboratories in Canada, the United States, and Switzerland. Finally, the nanoString assay could confidently predict subgroup in 88% of recent FFPE cases, of which 100% had accurate subgroup assignment. We present an assay based on nanoString technology that is capable of rapidly, reliably, and reproducibly assigning clinical FFPE medulloblastoma samples to their molecular subgroup, and which is highly suited for future medulloblastoma clinical trials
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Does mode of administration affect health-related quality-of-life outcomes after stroke?
Telephone interviews and postal surveys may be a resource-efficient way of assessing health-related quality-of-life post-stroke, if they produce data equivalent to face-to-face interviews. This study explored whether telephone interviews and postal surveys of the Stroke and Aphasia Quality of Life Scale (SAQOL-39g) yielded similar results to face-to-face interviews. Participants included people with aphasia and comprised two groups: group one (n =22) were 3-6 months post-stroke; group two (n =26) were ā„1 year post-stroke. They completed either a face-to-face and a telephone interview or a face-to-face interview and a postal survey of the SAQOL-39g. Response rates were higher for group two (87%) than for group one (72-77%). There were no significant differences between respondents and non-respondents on demographics, co-morbidities, stroke severity, or communication impairment. Concordance between face-to-face and telephone administrations (.90-.98) was excellent; and very good-excellent between face-to-face and postal administrations (.84-.96), although scores in postal administrations were lower (significant for psychosocial domain and overall SAQOL-39g in group two). These findings suggest that the SAQOL-39g yields similar results in different modes of administration. Researchers and clinicians may employ alternative modes, particularly in the longer term post-stroke, in order to reduce costs or facilitate clients with access difficulties
A genetic mouse model with postnatal Nf1 and p53 loss recapitulates the histology and transcriptome of human malignant peripheral nerve sheath tumor
BACKGROUND: Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas. Somatic inactivation of
METHODS: We combined 2 genetically modified alleles, an
RESULTS: Postnatal
CONCLUSIONS: The NP-Plp model recapitulates human MPNST genetically, histologically, and molecularly
On certain infinite extensions of the rationals with Northcott property
A set of algebraic numbers has the Northcott property if each of its subsets
of bounded Weil height is finite. Northcott's Theorem, which has many
Diophantine applications, states that sets of bounded degree have the Northcott
property. Bombieri, Dvornicich and Zannier raised the problem of finding fields
of infinite degree with this property. Bombieri and Zannier have shown that
\IQ_{ab}^{(d)}, the maximal abelian subfield of the field generated by all
algebraic numbers of degree at most , is such a field. In this note we give
a simple criterion for the Northcott property and, as an application, we deduce
several new examples, e.g.
\IQ(2^{1/d_1},3^{1/d_2},5^{1/d_3},7^{1/d_4},11^{1/d_5},...) has the Northcott
property if and only if
tends to infinity
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