H I Structure and Kinematics of the Interstellar Medium in the LITTLE THINGS Galaxies

We present a catalog of the neutral atomic hydrogen structures (H I holes) and the analysis of their properties in nearby (≤ 10.3 Mpc) gas-rich dwarf galaxies of the LITTLE THINGS (Local Irregulars That Trace Luminosity Extremes, The H I Nearby Galaxy Survey) group. We used high sensitivity (≤ 1.1 mJy beam-1 channel-1), high velocity resolution (1.3 km s-1 to 2.6 km s-1) and high linear resolution (average ~110 pc; angular resolution ~6”) H I data of 37 dwarf irregulars and four blue compact dwarf galaxies. We cataloged H I holes in the entire sample and studied the of the properties of holes. We also investigated the effect of H I porosity on star formation, and the correlation of the star formation rate (SFR) calculated from H I holes with standard star formation tracers Hα and FUV. We detected 306 H I holes in LITTLE THINGS galaxies. We confirmed 22 kpc-sized holes, the largest and the smallest hole diameters are about 2.3 kpc and 38 pc (resolution limit) respectively. The expansion velocities of the holes range from 5 km s-1 (upper limit) to 30 km s-1, and the rotational velocities range from 6 km s-1 to 77 km s-1. The H I disk radii of the galaxies range from about 0.5 kpc to 6.7 kpc. The kinetic ages of the holes range from about 1 to 127 Myr, and the estimated scale heights are varying from 61 pc to 653 pc. The percentage distribution of the holes outside and inside the V-band break radius is nearly uniform, 49% and 51% respectively. In LITTLE THINGS galaxies, we found no obvious correlation between the surface and volume porosities, and SFR. However, two highest and two lowest porosity galaxies have no star formation at present. The holes are consistent with the SFR estimated from the energy required to create a hole and the star formation rates measured from Hα and FUV, indicating that the holes are consistent with a star formation origin

Foreign Policy Views and U.S Standing in the World

What do Americans think about the US role in world affairs and why do they think the way they do? Americans typically do not think about foreign policy most of the time, and, as a consequence, know relatively little about it (Almond 1950, Lippmann 1955, Converse 1964, Erskine 1963, Edwards 1983, Sobel 1993, Holsti 2004, Canes-Wrone 2006, Page and Bouton 2006, Berinsky 2007). While foreign policy issues can become salient when major international events (like 9/11 and the Iraq War) arise or when political candidates focus on foreign policy (Aldrich, Sullivan and Borgida 1989), ceteris paribus, Americans know and care more about domestic politics (Delli-Carpini and Keeter 1996, Holsti 1994, Canes-Wrone 2006, Converse 1964). Consequently, typical Americans are broadly aware of foreign policy, and have some available attitudes about it (Page and Bouton 2006, Aldrich et al. 1989). However, except in the face of political priming by elites or exogenous shocks, such attitudes may not be broadly accessible when making political decisions, like voting

Nicotine and Cotinine – two pharmacologically active substances as parameters for the strain on fetuses and babies of mothers who smoke

Peer Reviewe

Das atmosphärische Aerosol-Vorläufergas SO₂: Messungen mit einem flugzeuggetragenem Massenspektrometer

The present diploma thesis addresses the development, characterization, and successful deployment of a chemical ionization mass spectrometer (CIMS) to precisely determine the atmospheric mixing ratio of sulfur dioxide at altitudes ranging from 0 to 12 km. During the international campaign ITOP (intercontinental transport of pollution) the CIMS instrument was integrated in the research aircraft Falcon of the German Aerospace Center (DLR). First results of the measurements performed during the ITOP campaign are presented in this diploma thesis. The time resolution of the instrument is about 1 s, and the error for a single data point remains within 10 to 17 % for average atmospheric SO2 mixing ratios. Using isotopically labeled sulfur dioxide (34SO2) as calibration gas, a calibration factor was determined which includes the influence of humidity, wall losses, temperature, and pressure on the measured gas concentrations

Determining Protease Substrate Selectivity and Inhibition by Label-Free Supramolecular Tandem Enzyme Assays

An analytical method has been developed for the continuous monitoring of protease activity on unlabeled peptides in real time by fluorescence spectroscopy. The assay is enabled by a reporter pair comprising the macrocycle cucurbit[7]uril (CB7) and the fluorescent dye acridine orange (AO). CB7 functions by selectively recognizing N-terminal phenylalanine residues as they are produced during the enzymatic cleavage of enkephalin-type peptides by the metalloendopeptidase thermolysin. The substrate peptides (e.g., Thr-Gly-Ala-Phe-Met-NH2) bind to CB7 with moderately high affinity (K ≈ 104 M–1), while their cleavage products (e.g., Phe-Met-NH2) bind very tightly (K \u3e 106 M–1). AO signals the reaction upon its selective displacement from the macrocycle by the high affinity product of proteolysis. The resulting supramolecular tandem enzyme assay effectively measures the kinetics of thermolysin, including the accurate determination of sequence specificity (Ser and Gly instead of Ala), stereospecificity (d-Ala instead of l-Ala), endo- versus exopeptidase activity (indicated by differences in absolute fluorescence response), and sensitivity to terminal charges (−CONH2 vs −COOH). The capability of the tandem assay to measure protease inhibition constants was demonstrated on phosphoramidon as a known inhibitor to afford an inhibition constant of (17.8 ± 0.4) nM. This robust and label-free approach to the study of protease activity and inhibition should be transferable to other endo- and exopeptidases that afford products with N-terminal aromatic amino acids

Changes in lipid distribution in E. coli strains in response to norfloxacin

Bacterial resistance to antibiotics has become an increasing threat, requiring not only the development of new targets in drug discovery, but more importantly, a better understanding of cellular response. In the current study, three closely related Escherichia coli strains, a wild type (MG1655), and an isogenic pair derived from the wild type (DPB635 and DPB636) are studied following exposure to sub lethal concentrations of antibiotic (norfloxacin) over time. In particular, genotype similarities between the three strains were assessed based on the lipid regulation response (e.g., presence/absence and up/down regulation). Lipid identification was performed using direct surface probe analysis (Matrix-assisted laser desorption/ionization, MALDI), coupled to high-resolution mass spectrometry (Fourier transform ion cyclotron resonance mass spectrometry, FT-ICR MS) followed by statistical analysis of variability and reproducibility across batches using internal standards. Inspection of the lipid profile showed that for the MG1655, DPB635 and DPB636 E. coli strains, a similar distribution of the altered lipids were observed after exposure to norfloxacin antibiotic (e.g., fatty acids and glycerol phospholipids are up and down regulated, respectively). Additionally, variations in the lipid distribution resemble the extent to which each strain can combat the antibiotic exposure. That is, the topA66 topoisomerase I mutation of DPB636 translates into diminished response related to antibiotic sensitivity when compared to MG1655 and the DPB635 strains

Structure of Extreme Correlated Equilibria: a Zero-Sum Example and its Implications

We exhibit the rich structure of the set of correlated equilibria by analyzing the simplest of polynomial games: the mixed extension of matching pennies. We show that while the correlated equilibrium set is convex and compact, the structure of its extreme points can be quite complicated. In finite games the ratio of extreme correlated to extreme Nash equilibria can be greater than exponential in the size of the strategy spaces. In polynomial games there can exist extreme correlated equilibria which are not finitely supported; we construct a large family of examples using techniques from ergodic theory. We show that in general the set of correlated equilibrium distributions of a polynomial game cannot be described by conditions on finitely many moments (means, covariances, etc.), in marked contrast to the set of Nash equilibria which is always expressible in terms of finitely many moments