Prolonging thermal barrier coated specimen life by thermal cycle management

Measurements were made of the rate of increase in temperature of a ZrO2-8Y2O3 thermal barrier coated (TBC) specimen for various values of fuel/air (F/A) ratios when the specimen is exposed to a 0.3 Mach burner flame. For rod specimens in a carousel, the heating rates increased with (F/A) ratio and were higher at the inward facing surface for a given (F/A). Plate specimens were more sensitive to burner variations. Calculated results are given for the radial stress in the coated rod specimens for variations in (F/A) ratios from 0.04 to 0.065. Over this range, the radial stress varies from 4.3 to 5.3 MPa. The results indicate that controlling the heating rate of a TBC by controlling the (F/A) ratio offers a potential method to prolong TBC cyclic life; uncontrolled (F/A) ratios will produce scatter in experimental results. Geometric arrangement can have an equivalent effect, but is usually fixed by design

Mining whole sample mass spectrometry proteomics data for biomarkers: an overview

In this paper we aim to provide a concise overview of designing and conducting an MS proteomics experiment in such a way as to allow statistical analysis that may lead to the discovery of novel biomarkers. We provide a summary of the various stages that make up such an experiment, highlighting the need for experimental goals to be decided upon in advance. We discuss issues in experimental design at the sample collection stage, and good practise for standardising protocols within the proteomics laboratory. We then describe approaches to the data mining stage of the experiment, including the processing steps that transform a raw mass spectrum into a useable form. We propose a permutation-based procedure for determining the significance of reported error rates. Finally, because of its general advantages in speed and cost, we suggest that MS proteomics may be a good candidate for an early primary screening approach to disease diagnosis, identifying areas of risk and making referrals for more specific tests without necessarily making a diagnosis in its own right. Our discussion is illustrated with examples drawn from experiments on bovine blood serum conducted in the Centre for Proteomic Research (CPR) at Southampton University

Transient intensity changes of cosmic rays beyond the heliospheric termination shock as observed at Voyager 1

This paper continues our studies of temporal variations of cosmic rays beyond the heliospheric termination shock (HTS) using Voyager 1 (V1) data when V1 was beyond 94 AU. This new study utilizes cosmic ray protons and electrons of several energies. Notable transient decreases of 5–50% are observed in galactic cosmic ray nuclei and electrons at V1 shortly after similar decreases are observed at Voyager 2 (V2) still inside the HTS. These decreases at V1 appear to be related to the large solar events in September 2005 and December 2006 and the resulting outward moving interplanetary shock. These two large interplanetary shocks were the largest observed at V2 after V1 crossed the HTS at the end of 2004. They were observed at V2 just inside the HTS at 2006.16 and 2007.43 providing timing markers for V1. From the timing of the intensity decreases observed at V1 as the shocks first reach the HTS and then later reach V1 itself, we can estimate the shock speed beyond the HTS to be between 240 and 300 km s^(−1) in both cases. From the timing of the decreases observed when the shock first reaches the HTS and then several months later encounters the heliopause, we can estimate the heliosheath thickness to be 31 ± 4 and 37 ± 6 AU, respectively, for the two sequences of three decreases seen at V1. These values, along with the distances to the HTS that are determined, give distances from the Sun to the heliopause of 121 ± 4 and 124 ± 6 AU, respectively

Thurstonian Scaling of Compositional Questionnaire Data

To prevent response biases, personality questionnaires may use comparative response formats. These include forced choice, where respondents choose among a number of items, and quantitative comparisons, where respondents indicate the extent to which items are preferred to each other. The present article extends Thurstonian modeling of binary choice data (Brown & Maydeu-Olivares, 2011a) to “proportion-of-total” (compositional) formats. Following Aitchison (1982), compositional item data are transformed into log-ratios, conceptualized as differences of latent item utilities. The mean and covariance structure of the log-ratios is modelled using Confirmatory Factor Analysis (CFA), where the item utilities are first-order factors, and personal attributes measured by a questionnaire are second-order factors. A simulation study with two sample sizes, N=300 and N=1000, shows that the method provides very good recovery of true parameters and near-nominal rejection rates. The approach is illustrated with empirical data from N=317 students, comparing model parameters obtained with compositional and Likert scale versions of a Big Five measure. The results show that the proposed model successfully captures the latent structures and person scores on the measured traits

Coupling Non-Gravitational Fields with Simplicial Spacetimes

The inclusion of source terms in discrete gravity is a long-standing problem. Providing a consistent coupling of source to the lattice in Regge Calculus (RC) yields a robust unstructured spacetime mesh applicable to both numerical relativity and quantum gravity. RC provides a particularly insightful approach to this problem with its purely geometric representation of spacetime. The simplicial building blocks of RC enable us to represent all matter and fields in a coordinate-free manner. We provide an interpretation of RC as a discrete exterior calculus framework into which non-gravitational fields naturally couple with the simplicial lattice. Using this approach we obtain a consistent mapping of the continuum action for non-gravitational fields to the Regge lattice. In this paper we apply this framework to scalar, vector and tensor fields. In particular we reconstruct the lattice action for (1) the scalar field, (2) Maxwell field tensor and (3) Dirac particles. The straightforward application of our discretization techniques to these three fields demonstrates a universal implementation of coupling source to the lattice in Regge calculus.Comment: 10 pages, no figures, Latex, fixed typos and minor corrections