6 research outputs found
FREE AND ZEOLITE-IMMOBILIZED PROBIOTIC MIXTURE VERSUS SODIUM VALPROATE IN PREVENTION OF OXIDATIVE STRESS AND MODULATION OF THE L-ARGININE INTRACELLULAR METABOLIC PATHWAYS IN THE RAT BRAIN AND BLOOD FOLLOWING DEXAMPHETAMINE-INDUCED BIPOLAR D
Experimental bipolar disorder (BD) was induced by repeated daily injection of the increasing doses of d-amphetamine sulfate (AMPH) (2-4 mg kg-1, 18 injections) in male young adult Wistar rats characterized by temporal arousal mimicked mania, and reduced exploratory and locomotor activities associated with behavioural depression under the condition of withdrawal of AMPH. At the end of the injection course, a stimulation of the lipid peroxidation processes and alterations in the mitochondrial and cytoplasmic activities of both arginase and nitric oxide synthase (NOS) were observed in the regions of brain corticolimbic system (prefrontal cortex, striatum, hippocampus and hypothalamus) and blood leukocytes. We have shown for the first time that a reversal treatment with the mixture of the specific probiotics with psycho- and antifungal activities in free (PMF) and zeolite-immobilized (PMZ) forms, and/or with a mood stabilizer, sodium valproate (VPA) inhibited oxidative stress and modulated differentially the L-arginine metabolic pathways in the brain and blood following AMPH-induced BD. Both PMF and PMZ efficiently normalized the activities of arginase isoforms and upregulated the suppressed intracellular NOS along with the gut microbiota restoration and prevention of the histopathological changes in the brain regions accompanied by normalization of rat behaviour
ΠΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π°ΡΠΏΠ΅ΠΊΡΡ ΡΠ½ΡΠ΅ΡΠΎΠ²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ Π² Π ΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ Π€Π΅Π΄Π΅ΡΠ°ΡΠΈΠΈ Π·Π° ΠΏΠ΅ΡΠΈΠΎΠ΄ 2018β2019 Π³Π³.
Aim: Analysis of enterovirus infection morbidity and characteristics of the etiological agents of this infection on some territories of Russia in 2017.Materials and methods: We investigated 7858 samples of the biological material from the patients suffering from enterovirus infection. The isolation and identification of enteroviruses were conducted by virological and molecular methods.Results: The epidemic process and the clinical picture of enterovirus infection on different territories had some peculiarities. On some territories enterovirus meningitis was the predominant form of infection, on other territories enterovirus infection with exanthema prevailed. In Saint-Petersburg, Archangel and Saratov regions the percentage of enterovirus infection cases with the clinical picture of enterovirus meningitis was significantly higher than the percentage of enterovirus infection with exanthema. In the Komi Republic, Leningrad and Murmansk regions the percentage of infection with exanthema was statistically higher than the enterovirus meningitis portion. Enteroviruses of 30 serotypes were detected in the samples of patients suffering from enterovirus infection. We determined the etiology of sporadic and epidemic cases of enterovirus infection represented by different clinical forms. On some territories the epidemic foci of enterovirus infection among children were revealed. The etiological agents of enterovirus meningitis foci in Saint-Petersburg, Murmansk and Saratov regions were Coxsackievirus B5, Coxsackievirus B4 and Echovirus 30. The foci of enterovirus infection with exanthema in Archangel, Leningrad, Murmansk and Novgorod regions were caused by Coxsackieviruses A10, A16 and A6.Conclusion: The clinical forms of enterovirus infection on some territories were provoked by enteroviruses which dominated in the circulation on one or other territory. Enteroviruses of species B, mainly Echovirus 30, Echovirus 6 and Coxsackieviruses B1β6 were the etiological agents of enterovirus meningitis. The etiological factors of enterovirus infection with exanthema were Enteroviruses of species A, mainly Coxsackieviruses of different serotypes as well as Enterovirus 71.Π¦Π΅Π»Ρ: Π°Π½Π°Π»ΠΈΠ· Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡΠΈ ΡΠ½ΡΠ΅ΡΠΎΠ²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠ΅ΠΉ ΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° Π΅Π΅ ΡΡΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π°Π³Π΅Π½ΡΠΎΠ² Π½Π° ΡΡΠ΄Π΅ ΡΠ΅ΡΡΠΈΡΠΎΡΠΈΠΉ Π ΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ Π€Π΅Π΄Π΅ΡΠ°ΡΠΈΠΈ Π² 2018β2019 Π³Π³.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ: ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ 7858 ΠΏΡΠΎΠ± Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° ΠΎΡ Π±ΠΎΠ»ΡΠ½ΡΡ
ΡΠ½ΡΠ΅ΡΠΎΠ²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠ΅ΠΉ. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΈ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΡΠ½ΡΠ΅ΡΠΎΠ²ΠΈΡΡΡΠΎΠ² ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π²ΠΈΡΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ: ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡ ΡΠ½ΡΠ΅ΡΠΎΠ²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ Π½Π° ΡΠ°Π·Π½ΡΡ
ΡΠ΅ΡΡΠΈΡΠΎΡΠΈΡΡ
ΠΈΠΌΠ΅Π»ΠΈ ΠΎΡΠ»ΠΈΡΠΈΡ. ΠΠ° ΠΎΠ΄Π½ΠΈΡ
ΡΠ΅ΡΡΠΈΡΠΎΡΠΈΡΡ
ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°Π»ΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ Ρ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎΠΉ ΡΠ½ΡΠ΅ΡΠΎΠ²ΠΈΡΡΡΠ½ΠΎΠ³ΠΎ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΈΡΠ°, Π½Π° Π΄ΡΡΠ³ΠΈΡ
ΡΠ΅ΡΡΠΈΡΠΎΡΠΈΡΡ
ΠΏΡΠ΅Π²Π°Π»ΠΈΡΠΎΠ²Π°Π»ΠΈ ΡΠΊΠ·Π°Π½ΡΠ΅ΠΌΠ½ΡΠ΅ ΡΠΎΡΠΌΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ. Π Π‘Π°Π½ΠΊΡ-ΠΠ΅ΡΠ΅ΡΠ±ΡΡΠ³Π΅, ΠΡΡ
Π°Π½Π³Π΅Π»ΡΡΠΊΠΎΠΉ ΠΈ Π‘Π°ΡΠ°ΡΠΎΠ²ΡΠΊΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΡΡ
ΡΠ΄Π΅Π»ΡΠ½ΡΠΉ Π²Π΅Ρ ΡΠ»ΡΡΠ°Π΅Π² ΡΠ½ΡΠ΅ΡΠΎΠ²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ Ρ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΉ ΡΠ½ΡΠ΅ΡΠΎΠ²ΠΈΡΡΡΠ½ΠΎΠ³ΠΎ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΈΡΠ° Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ ΠΏΡΠ΅Π²ΡΡΠ°Π» Π°Π½Π°Π»ΠΎΠ³ΠΈΡΠ½ΡΠΉ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ Π΄Π»Ρ ΡΠΊΠ·Π°Π½ΡΠ΅ΠΌΠ½ΡΡ
ΡΠΎΡΠΌ ΡΠ½ΡΠ΅ΡΠΎΠ²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ. Π Π Π΅ΡΠΏΡΠ±Π»ΠΈΠΊΠ΅ ΠΠΎΠΌΠΈ, ΠΠ΅Π½ΠΈΠ½Π³ΡΠ°Π΄ΡΠΊΠΎΠΉ ΠΈ ΠΡΡΠΌΠ°Π½ΡΠΊΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΡΡ
Π΄ΠΎΠ»Ρ ΡΠ»ΡΡΠ°Π΅Π² ΡΠ½ΡΠ΅ΡΠΎΠ²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ Ρ ΡΠΊΠ·Π°Π½ΡΠ΅ΠΌΠ½ΡΠΌΠΈ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡΠΌΠΈ Π±ΡΠ»Π° Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ Π²ΡΡΠ΅, ΡΠ΅ΠΌ Π΄ΠΎΠ»Ρ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΡΠ½ΡΠ΅ΡΠΎΠ²ΠΈΡΡΡΠ½ΡΠΌ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΈΡΠΎΠΌ. ΠΠ½ΡΠ΅ΡΠΎΠ²ΠΈΡΡΡΡ 30 ΡΠ΅ΡΠΎΡΠΈΠΏΠΎΠ² Π±ΡΠ»ΠΈ Π΄Π΅ΡΠ΅ΠΊΡΠΈΡΠΎΠ²Π°Π½Ρ Π² ΠΏΡΠΎΠ±Π°Ρ
ΠΎΡ Π±ΠΎΠ»ΡΠ½ΡΡ
ΡΠ½ΡΠ΅ΡΠΎΠ²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠ΅ΠΉ. ΠΡΠ»Π° ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° ΡΡΠΈΠΎΠ»ΠΎΠ³ΠΈΡ ΡΠΏΠΎΡΠ°Π΄ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ Π³ΡΡΠΏΠΏΠΎΠ²ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΡΠ½ΡΠ΅ΡΠΎΠ²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠ΅ΠΉ Ρ ΡΠ°Π·Π½ΡΠΌΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΠΎΡΠΌΠ°ΠΌΠΈ. ΠΠ° Π½Π΅ΠΊΠΎΡΠΎΡΡΡ
ΡΠ΅ΡΡΠΈΡΠΎΡΠΈΡΡ
Π±ΡΠ»ΠΈ Π²ΡΡΠ²Π»Π΅Π½Ρ ΠΎΡΠ°Π³ΠΈ Π³ΡΡΠΏΠΏΠΎΠ²ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΡΡΠ΅Π΄ΠΈ Π΄Π΅ΡΠ΅ΠΉ. ΠΡΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Π°Π³Π΅Π½ΡΠ°ΠΌΠΈ Π³ΡΡΠΏΠΏΠΎΠ²ΡΡ
Β Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΡΠ½ΡΠ΅ΡΠΎΠ²ΠΈΡΡΡΠ½ΡΠΌ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΈΡΠΎΠΌ Π² Π‘Π°Π½ΠΊΡ-ΠΠ΅ΡΠ΅ΡΠ±ΡΡΠ³Π΅, ΠΡΡΠΌΠ°Π½ΡΠΊΠΎΠΉ ΠΈ Π‘Π°ΡΠ°ΡΠΎΠ²ΡΠΊΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΡΡ
Π±ΡΠ»ΠΈ ΡΠ½ΡΠ΅ΡΠΎΠ²ΠΈΡΡΡΡ ΠΠΎΠΊΡΠ°ΠΊΠΈ Π5, ΠΠΎΠΊΡΠ°ΠΊΠΈ Π4 ΠΈ Π²ΠΈΡΡΡ ECHO30. ΠΡΡΠΏΠΏΠΎΠ²ΡΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ Ρ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎΠΉ Π²ΠΈΡΡΡΠ½ΠΎΠΉ ΡΠΊΠ·Π°Π½ΡΠ΅ΠΌΡ Π² ΠΡΡ
Π°Π½Π³Π΅Π»ΡΡΠΊΠΎΠΉ, ΠΠ΅Π½ΠΈΠ½Π³ΡΠ°Π΄ΡΠΊΠΎΠΉ, ΠΡΡΠΌΠ°Π½ΡΠΊΠΎΠΉ ΠΈ ΠΠΎΠ²Π³ΠΎΡΠΎΠ΄ΡΠΊΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΡΡ
Π±ΡΠ»ΠΈ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Ρ ΡΠ½ΡΠ΅ΡΠΎΠ²ΠΈΡΡΡΠ°ΠΌΠΈ ΠΠΎΠΊΡΠ°ΠΊΠΈ Π10, Π16 ΠΈ Π6.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅: ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠΎΡΠΌΡ ΡΠ½ΡΠ΅ΡΠΎΠ²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ Π½Π° ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΡ
ΡΠ΅ΡΡΠΈΡΠΎΡΠΈΡΡ
Π±ΡΠ»ΠΈ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Ρ ΡΠ½ΡΠ΅ΡΠΎΠ²ΠΈΡΡΡΠ°ΠΌΠΈ, ΠΊΠΎΡΠΎΡΡΠ΅ Π΄ΠΎΠΌΠΈΠ½ΠΈΡΠΎΠ²Π°Π»ΠΈ Π² ΡΠΈΡΠΊΡΠ»ΡΡΠΈΠΈ Π½Π° ΡΠΎΠΉ ΠΈΠ»ΠΈ ΠΈΠ½ΠΎΠΉ ΡΠ΅ΡΡΠΈΡΠΎΡΠΈΠΈ. ΠΡΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Π°Π³Π΅Π½ΡΠ°ΠΌΠΈ ΡΠ½ΡΠ΅ΡΠΎΠ²ΠΈΡΡΡΠ½ΠΎΠ³ΠΎ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΈΡΠ° Π±ΡΠ»ΠΈ ΡΠ½ΡΠ΅ΡΠΎΠ²ΠΈΡΡΡΡ Π²ΠΈΠ΄Π° Π, ΡΠ°ΡΠ΅ Π²ΡΠ΅Π³ΠΎ ECHO30, ECHO6 ΠΈ ΠΠΎΠΊΡΠ°ΠΊΠΈ Π1β6. ΠΡΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Π°Π³Π΅Π½ΡΠ°ΠΌΠΈ ΡΠΊΠ·Π°Π½ΡΠ΅ΠΌΠ½ΡΡ
ΡΠΎΡΠΌ ΡΠ½ΡΠ΅ΡΠΎΠ²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ ΡΠ²Π»ΡΠ»ΠΈΡΡ ΡΠ½ΡΠ΅ΡΠΎΠ²ΠΈΡΡΡΡ Π²ΠΈΠ΄Π° Π (Π² ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΌ, Π²ΠΈΡΡΡΡ ΠΠΎΠΊΡΠ°ΠΊΠΈ Π ΡΠ°Π·Π½ΡΡ
ΡΠ΅ΡΠΎΡΠΈΠΏΠΎΠ² ΠΈ ΡΠ½ΡΠ΅ΡΠΎΠ²ΠΈΡΡΡ 71 ΡΠΈΠΏΠ°)
Radiation Damping of Surface Plasmons in a Pair of Nanoparticles and in Nanoparticles near Interfaces
A theory of surface plasmon radiation damping in a system
of coupled
spherical metallic nanoparticles is developed, and a simple formula
for the radiation line width is obtained for the first time. It is
shown that as a result of surface plasmon frequency redshift, a notable
reduction of the radiation damping rate takes place. For small separations,
the radiation line width narrows by a factor of 3 as compared to large
separations. The theory is expanded to the case of a spherical metallic
nanoparticle placed near an interface of two dielectric media. The
dependence of the redshift of surface plasmon frequency and the radiation
damping rate on the particleβinterface separation are calculated.
It is revealed that in both cases, a decrease of refractive index
of the surrounding media also leads to a decrease of the damping rate