Track reconstruction in the LHCb experiment

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Coping strategies of older adults with a recent hip fracture within inpatient geriatric rehabilitation

ObjectivesCoping strategies may play an important role as facilitator or barrier for functional recovery after hip fracture. This study explored 1] active and passive coping strategies in hip fracture patients within inpatient geriatric rehabilitation (GR) 2] the association of these coping strategies with depression, anxiety, pain and health-related quality of life (HRQoL)MethodSecondary data analysis (FIT-HIP trial). Participants were patients with hip fracture, aged 65+ years, admitted to post-acute GR units. Coping was assessed using the 'Active Tackling' and 'Passive Reacting' subscale of Utrecht Coping List (UCL). Depression, anxiety, pain and HRQoL was assessed using GDS-8, HADS-A, NPRS and EQ5D-VAS. Based on UCL norm tables - for both subscales - we dichotomized the group into (extremely) high use of this coping strategy i.e. 'predominantly active coping' (PAC), and 'predominantly passive coping' (PPC); versus their corresponding 'residual groups', i.e. the remaining participants.Results72 participants were included. Participants mostly used active coping (PAC: 33.3%), however those engaging in passive coping (23.6%) had significantly more depression and anxiety symptoms (GDS-8 >= 3: 31.1% respectively 9.1%, p = 0.040; HADS-A >= 7: 58.8% vs 10.9%; p = 0.00).ConclusionActive tackling and passive reacting coping strategies are used by up to one-third of patients with recent hip fracture. Passive coping was associated with more symptoms of depression and anxiety, which in turn may influence rehabilitation negatively. Screening of (passive) coping strategies could contribute to prompt identification of hip fracture patients at risk for negative health outcomes.Public Health and primary careGeriatrics in primary car

Using contextual queries

Search engines generally treat search requests in isolation. The results for a given query are identical, independent of the user, or the context in which the user made the request. An approach is demonstrated that explores implicit contexts as obtained from a document the user is reading. The approach inserts into an original (web) document functionality to directly activate context driven queries that yield related articles obtained from various information sources

Prevalence of BRCA1 in a hospital-based population of Dutch breast cancer patients

The prevalence of disease-related BRCA1 mutations was investigated in 642 Dutch breast cancer patients not selected for family history or age at diagnosis. They were tested for germline mutations in the BRCA1 gene using an assay which detects small deletions and insertions (DSDI), as well as the two major genomic founder deletions present in the Dutch population. Data on family history and bilateral breast cancer were obtained retrospectively. Ten protein truncating mutations were detected and one in-frame deletion with an unknown relation to disease risk. Four patients carried the Dutch founder deletion of exon 22. Based on these results the estimated prevalence of breast cancer in the general population in the Netherlands attributable to BRCA1 mutations is 2.1%. Under 40 years-of-age and under 50 years-of-age this prevalence is 9.5% and 6.4%, respectively. All mutation carriers were under 50 years-of-age at diagnosis of the first breast cancer, and five did not have any relative with breast cancer. The proportions of bilateral breast cancer in the mutation carriers and non-carriers did not differ from each other. These data indicate that in the general Dutch breast cancer population the great majority of BRCA1 mutations will be found in women diagnosed under 50 years-of-age. © 2000 Cancer Research Campaig

Investigation of the Effect of a Diamine-Based Friction Modifier on Micropitting and the Properties of Tribofilms in Rolling-Sliding Contacts

The effect of N-Tallow-1,3-DiaminoPropane (TDP) on friction, rolling wear and micropitting has been investigated with the ultimate objective of developing lubricants with no or minimal environmental impact. A Mini Traction Machine (MTM-SLIM) has been utilised in order to generate tribofilms and observe the effect of TDP on anti-wear tribofilm formation and friction. Micropitting was induced on the surface of specimens using a MicroPitting Rig (MPR). The X-ray Photoelectron Spectroscopy (XPS) surface analytical technique has been employed to investigate the effect of TDP on the chemical composition of the tribofilm while Atomic Force Microscopy (AFM) was used to generate high resolution topographical images of the tribofilms formed on the MTM discs. Experimental and analytical results showed that TDP delays the Zinc DialkylDithioPhosphate (ZDDP) anti-wear tribofilm formation. TDP in combination with ZDDP induces a thinner and smoother anti-wear tribofilm with a modified chemical structure composed of mixed Fe/Zn (poly)phosphates. The sulphide contribution to the tribofilm and oxygen-to-phosphorous atomic concentration ratio are greater in the bulk of the tribofilm derived from a combination of TDP and ZDDP compared to a tribofilm derived from ZDDP alone. Surface analysis showed that utilising TDP effectively mitigates micropitting wear in the test conditions used in this study. Reduction of micropitting, relevant to rolling bearing applications, can be attributed to the improved running-in procedure, reduced friction, formation of a smoother tribofilm and modification of the tribofilm composition induced by TDP

Ambiguity of human gene symbols in LocusLink and MEDLINE: creating an inventory and a disambiguation test collection

Genes are discovered almost on a daily basis and new names have to be found. Although there are guidelines for gene nomenclature, the naming process is highly creative. Human genes are often named with a gene symbol and a longer, more descriptive term; the short form is very often an abbreviation of the long form. Abbreviations in biomedical language are highly ambiguous, i.e., one gene symbol often refers to more than one gene.Using an existing abbreviation expansion algorithm,we explore MEDLINE for the use of human gene symbols derived from LocusLink. It turns out that just over 40% of these symbols occur in MEDLINE, however, many of these occurrences are not related to genes. Along the process of making an inventory, a disambiguation test collection is constructed automatically

Color-Octet Fragmentation and the psi' Surplus at the Tevatron

The production rate of prompt $\psi'$'s at large transverse momentum at the Tevatron is larger than theoretical expectations by about a factor of 30. As a solution to this puzzle, we suggest that the dominant $\psi'$ production mechanism is the fragmentation of a gluon into a $c \bar c$ pair in a pointlike color-octet S-wave state, which subsequently evolves nonperturbatively into a $\psi'$ plus light hadrons. The contribution to the fragmentation function from this process is enhanced by a short-distance factor of $1/\alpha_s^2$ relative to the conventional color-singlet contribution. This may compensate for the suppression by $v^4$, where $v$ is the relative momentum of the charm quark in the $\psi'$. If this is indeed the dominant production mechanism at large $p_T$, then the prompt $\psi'$'s that are observed at the Tevatron should almost always be associated with a jet of light hadrons.Comment: 9 pages, LaTe

Ecdysteroid Hormones Link the Juvenile Environment to Alternative Adult Life Histories in a Seasonal Insect

The conditional expression of alternative life strategies is a widespread feature of animal life and a pivotal adaptation to life in seasonal environments. To optimally match suites of traits to seasonally changing ecological opportunities, animals living in seasonal environments need mechanisms linking information on environmental quality to resource allocation decisions. The butterfly Bicyclus anynana expresses alternative adult life histories in the alternating wet and dry seasons of its habitat as endpoints of divergent developmental pathways triggered by seasonal variation in preadult temperature. Pupal ecdysteroid hormone titers are correlated with the seasonal environment, but whether they play a functional role in coordinating the coupling of adult traits in the alternative life histories is unknown. Here, we show that manipulating pupal ecdysteroid levels is sufficient to mimic in direction and magnitude the shifts in adult reproductive resource allocation normally induced by seasonal temperature. Crucially, this allocation shift is accompanied by changes in ecologically relevant traits, including timing of reproduction, life span, and starvation resistance. Together, our results support a functional role for ecdysteroids during development in mediating strategic reproductive investment decisions in response to predictive indicators of environmental quality. This study provides a physiological mechanism for adaptive developmental plasticity, allowing organisms to cope with variable environments.European Union’s FP6 Programme (Network of Excellence LifeSpan FP6/036894), FCT fellowship (SFRH/BD/45486/2008)