Influence of aerosol and surface reflectance variability on hyperspectral observed radiance

Current aerosol retrievals based on visible and near infrared remote-sensing, are prone to loss of accuracy, where the assumptions of the applied algorithm are violated. This happens mostly over land and it is related to misrepresentation of specific aerosol conditions or surface properties. New satellite missions, based on high spectral resolution instruments, such as PRISMA (Hyperspectral Precursor of the Application Mission), represent a valuable opportunity to improve the accuracy of τ<sup>a</sup><sub>550</sub> retrievable from a remote-sensing system developing new atmospheric measurement techniques. This paper aims to address the potential of these new observing systems in more accurate retrieving τ<sup>a</sup><sub>550</sub>, specifically over land in heterogeneous and/or homogeneous areas composed by dark and bright targets. The study shows how the variation of the hyperspectral observed radiance can be addressed to recognise a variation of Δτ<sup>a</sup><sub>550</sub> = 0.02. The goal has been achieved by using simulated radiances by combining two aerosol models (urban and continental) and two reflecting surfaces: dark (represented by water) and bright (represented by sand) for the PRISMA instrument, considering the environmental contribution of the observed radiance, i.e., the adjacency effect. Results showed that, in the continental regime, the expected instrument sensitivity would allow for retrieval accuracy of the aerosol optical thickness at 550 nm of 0.02 or better, with a dark surface surrounded by dark areas. The study also showed that for the urban regime, the surface plays a more significant role, with a bright surface surrounded by dark areas providing favourable conditions for the aerosol load retrievals, and dark surfaces representing less suitable situations for inversion independently of the surroundings. However, over all, the results obtained provide evidence that high resolution observations of Earth spectrum between 400 and 1000 nm would allow for a significant improvement of the accuracy of the τ<sup>a</sup><sub>550</sub> for anthropogenic/natural aerosols over land

Performance analysis of MPEG-4 decoder and encoder

© 2002 Croatian Soc. Electronics in Marine-ELMAR. A performance analysis of MPEG-4 encoder and decoder programs on a standard personal computer is presented. The paper first describes the MPEG-4 computational load and discusses related works, then outlines the performance analysis. Experimental results show that while the decoder program can be easily executed in real time, the encoder requires execution times in the order of seconds per frame which call for substantial optimisation to satisfy real-time constraints

Correction of sun glint effect on MIVIS data of the Sicily campaign in July 2000

To assess the suspended and dissolved matter in water in the visible and near infrared spectral regions it is necessary to estimate with adequate accuracy the water leaving radiance. Consequently radiance measured by a remote sensor has to be corrected from the atmospheric and the sea surface effects consisting in the path radiance and the sun and sky glitter radiance contributions. This paper describes the application of the sun glint correction scheme on to airborne hyperspectral MIVIS measurements acquired on the area of the Straits of Messina during the campaign in July 2000. In the Messina case study data have been corrected for the atmospheric effects and for the sun-glitter contribution evaluated following the method proposed by Cox and Munk (1954, 1956). Comparison between glitter contaminated and glitter free data has been made taking into account the radiance profiles relevant to selected scan lines and the spectra of different pixels belonging to the same scan line and located out and inside the sun glitter area. The results show that spectra after correction have the same profile as the contaminated ones, although, at this stage, free glint data have not yet been used in water constituent retrieval and consequently the reliability of such correction cannot be completely evaluated

Measurement of Dielectric Suppression of Bremsstrahlung

In 1953, Ter-Mikaelian predicted that the bremsstrahlung of low energy photons in a medium is suppressed because of interactions between the produced photon and the electrons in the medium. This suppression occurs because the emission takes place over on a long distance scale, allowing for destructive interference between different instantaneous photon emission amplitudes. We present here measurements of bremsstrahlung cross sections of 200 keV to 20 MeV photons produced by 8 and 25 GeV electrons in carbon and gold targets. Our data shows that dielectric suppression occurs at the predicted level, reducing the cross section up to 75 percent in our data.Comment: 11 pages, format is postscript file, gzip-ed, uuencode-e

Computational drug discovery under RNA times

RNA molecules play many functional and regulatory roles in cells, and hence, have gained considerable traction in recent times as therapeutic interventions. Within drug discovery, structure-based approaches have successfully identified potent and selective small-molecule modulators of pharmaceutically relevant protein targets. Here, we embrace the perspective of computational chemists who use these traditional approaches, and we discuss the challenges of extending these methods to target RNA molecules. In particular, we focus on recognition between RNA and small-molecule binders, on selectivity, and on the expected properties of RNA ligands

Relations between morphological settings and vegetation covers in a medium relief landscape of Central Italy

Morphometric units and vegetation classes were determined by applying two classification methods to the Soratte Mount area, a medium relief structure within the Italian Latium region. The study aims at defining the relationships between vegetation and landform types and highlighting the main morphological characteristics within examined land cover classes. These were the result of the application of a supervised classification method to the first 28 (VIS-NIR) bands of the airborne MIVIS data collected within an extensive survey campaign over Rome Province. The analysis was supported by photo-interpretation of peculiar MIVIS band combinations and by data acquired during field surveys and from a pre-existing vegetation map. The morphometric data were obtained by processing a raster DEM created from topographic maps. These data were processed by means of a new morphometric classification method based on the statistical multivariate investigation of local topographic gradients, calculated along the 8 azimuth directions of each pixel neighbourhood. Such approach quickly estimates the spatial distribution of different types of homogeneous terrain units, emphasizing the impact of erosional and tectonic processes on the overall relief. Mutual relations between morphometric units and vegetation types were assessed by performing a correspondence analysis between the results of the two classifications

Assessment of capillary volumetric blood microsampling for the analysis of central nervous system drugs and metabolites

Therapeutic drug monitoring (TDM) is an important tool for correlating the administered drug dose to drug and metabolite concentrations in the body and to therapeutic and adverse effects. In the case of treatment with drugs active on the central nervous system (CNS), frequent TDM becomes really useful, especially for patient compliance checking and for therapy optimisation. The selective serotonin reuptake inhibitors (SSRIs) fluoxetine and sertraline, chosen as target compounds for this study, are two antidepressants mainly used for major depression, but also for obsessive-compulsive disorder associated with neurodegenerative diseases and for eating disorders. Microsampling approaches can be used to make TDM patient-friendly, by means of minimally invasive fingerpricking instead of classic invasive venipuncture. In this study, an innovative volumetric microsampling approach based on the use of hemaPEN technology is proposed to simultaneously obtain four identical dried whole blood microsamples by means of a single capillary sampling. The developed strategy shows significant advantages in terms of blood collection and storage, fast and feasible extraction procedure and sensitive LC-MS/MS analysis, also providing satisfactory validation results (extraction yield >81%, RSD <12.0%, and <6.3% loss in analyte stability after 3 months). The proposed methodology has proven to be sound and reliable for application to the TDM of psychiatric patients treated with antidepressant drugs such as fluoxetine and sertraline. The original capillary volumetric microsampling procedure using hemaPEN has been demonstrated to be suitable for the accurate sampling of capillary whole blood, in order to be successfully exploited in self- and home-sampling procedures in future and to pave the way for precision medicine approaches for the treatment of CNS disorders

CNR LARA project, Italy: Airborne laboratory for environmental research

The increasing interest for the environmental problems and the study of the impact on the environment due to antropic activity produced an enhancement of remote sensing applications. The Italian National Research Council (CNR) established a new laboratory for airborne hyperspectral imaging, the LARA Project (Laboratorio Aero per Ricerche Ambientali - Airborne Laboratory for Environmental Research), equipping its airborne laboratory, a CASA-212, mainly with the Daedalus AA5000 MIVIS (Multispectral Infrared and Visible Imaging Spectrometer) instrument. MIVIS's channels, spectral bandwidths, and locations are chosen to meet the needs of scientific research for advanced applications of remote sensing data. MIVIS can make significant contributions to solving problems in many diverse areas such as geologic exploration, land use studies, mineralogy, agricultural crop studies, energy loss analysis, pollution assessment, volcanology, forest fire management and others. The broad spectral range and the many discrete narrow channels of MIVIS provide a fine quantization of spectral information that permits accurate definition of absorption features from a variety of materials, allowing the extraction of chemical and physical information of our environment. The availability of such a hyperspectral imager, that will operate mainly in the Mediterranean area, at the present represents a unique opportunity for those who are involved in environmental studies and land-management to collect systematically large-scale and high spectral-spatial resolution data of this part of the world. Nevertheless, MIVIS deployments will touch other parts of the world, where a major interest from the international scientific community is present