529 research outputs found
La fiebre de Texas y los métodos para prevenirla
La fiebre de Texas es un obstáculo muy serio al desarrollo y á la prosperidad de la industria ganadera del Sud de los Estados Unidos. Ella ha sido bien comprendida desde las investigaciones y descubrimientos de Smith y Kilborne. El trabajo de estos sabios ha demostrado de un modo con cluyente que la causa de la enfermedad es un parásito intraglobular, cuyo estadio intermediario de desarrollo tiene lugar en la garrapata, formando asà ésta última el factor indirecto, pero absolutamente esencial, en la producción natural de la enfermedad.Facultad de Ciencias Agrarias y Forestale
New cloud chamber experiments on the heterogeneous ice nucleation ability of oxalic acid in the immersion mode
The heterogeneous ice nucleation ability of oxalic acid in the immersion
mode has been investigated by controlled expansion cooling runs with
airborne, ternary solution droplets composed of, (i), sodium chloride,
oxalic acid, and water (NaCl/OA/H<sub>2</sub>O) and, (ii), sulphuric acid, oxalic
acid, and water (H<sub>2</sub>SO<sub>4</sub>/OA/H<sub>2</sub>O). Polydisperse aerosol
populations with median diameters ranging from 0.5–0.7 μm and
varying solute concentrations were prepared. The expansion experiments were
conducted in the AIDA aerosol and cloud chamber of the Karlsruhe Institute
of Technology at initial temperatures of 244 and 235 K. In the ternary
NaCl/OA/H<sub>2</sub>O system, solid inclusions of oxalic acid, presumably
nucleated as oxalic acid dihydrate, were formed by temporarily exposing the
ternary solution droplets to a relative humidity below the efflorescence
point of NaCl. The matrix of the crystallised NaCl particulates triggered
the precipitation of the organic crystals which later remained as solid
inclusions in the solution droplets when the relative humidity was
subsequently raised above the deliquescence point of NaCl. The embedded
oxalic acid crystals reduced the critical ice saturation ratio required for
the homogeneous freezing of pure NaCl/H<sub>2</sub>O solution droplets at a
temperature of around 231 K from 1.38 to about 1.32. Aqueous solution
droplets with OA inclusions larger than about 0.27 ÎĽm in diameter
efficiently nucleated ice by condensation freezing when they were activated
to micron-sized cloud droplets at 241 K, i.e., they froze well above the
homogeneous freezing temperature of pure water droplets of about 237 K. Our
results on the immersion freezing potential of oxalic acid corroborate the
findings from a recent study with emulsified aqueous solutions containing
crystalline oxalic acid. In those experiments, the crystallisation of oxalic
acid diyhdrate was triggered by a preceding homogeneous freezing cycle with
the emulsion samples. The expansion cooling cycles with ternary
H<sub>2</sub>SO<sub>4</sub>/OA/H<sub>2</sub>O solution droplets were aimed to analyse whether
those findings can be transferred to ice nucleation experiments with
airborne oxalic acid containing aerosol particles. Under our experimental
conditions, the efficiency by which the surface of homogeneously nucleated
ice crystals triggered the precipitation of oxalic acid dihydrate was very
low, i.e., less than one out of a hundred ice crystals that were formed by
homogeneous freezing in a first expansion cooling cycle left behind an
ice-active organic crystal that acted as immersion freezing nucleus in a
second expansion cooling cycle
Probing ice clouds by broadband mid-infrared extinction spectroscopy: case studies from ice nucleation experiments in the AIDA aerosol and cloud chamber
International audienceSeries of infrared extinction spectra of ice crystals were recorded in the 6000?800 cm-1 wavenumber regime during expansion cooling experiments in the large aerosol and cloud chamber AIDA of Forschungszentrum Karlsruhe. Either supercooled sulphuric acid solution droplets or dry mineral dust particles were added as seed aerosols to initiate ice formation after having established ice supersaturated conditions inside the chamber. The various ice nucleation runs were conducted at temperatures between 237 and 195 K, leading to median sizes of the nucleated ice particles of 1?15 µm. The measured infrared spectra were fitted with reference spectra from T-matrix calculations to retrieve the number concentration as well as the number size distribution of the generated ice clouds. The ice particles were modelled as finite circular cylinders with aspect ratios ranging from 0.5 to 3.0. Benefiting from the comprehensive diagnostic tools for the characterisation of ice clouds which are available at the AIDA facility, the infrared retrieval results with regard to the ice particle number concentration could be compared to independent measurements with various optical particle counters. This provided a unique chance to quantitatively assess potential errors or solution ambiguities in the retrieval procedure which mainly originate from the difficulty to find an appropriate shape representation for the aspherical particle habits of the ice crystals. Based on these inter-comparisons, we demonstrate that there is no standard retrieval approach which can be routinely applied to all different experimental scenarios. In particular, the concept to account for the asphericity of the ice crystals, the a priori constraints which might be imposed on the unknown number size distribution of the ice crystals (like employing an analytical distribution function), and the wavenumber range which is included in the fitting algorithm should be carefully adjusted to each single retrieval problem
Technical Note: A numerical test-bed for detailed ice nucleation studies in the AIDA cloud simulation chamber
The AIDA (Aerosol Interactions and Dynamics in the Atmosphere) aerosol and cloud chamber of Forschungszentrum Karlsruhe can be used to test the ice forming ability of aerosols. The AIDA chamber is extensively instrumented including pressure, temperature and humidity sensors, and optical particle counters. Expansion cooling using mechanical pumps leads to ice supersaturation conditions and possible ice formation. In order to describe the evolving chamber conditions during an expansion, a parcel model was modified to account for diabatic heat and moisture interactions with the chamber walls. Model results are shown for a series of expansions where the initial chamber temperature ranged from −20°C to −60°C and which used desert dust as ice forming nuclei. During each expansion, the initial formation of ice particles was clearly observed. For the colder expansions there were two clear ice nucleation episodes. <br><br> In order to test the ability of the model to represent the changing chamber conditions and to give confidence in the observations of chamber temperature and humidity, and ice particle concentration and mean size, ice particles were simply added as a function of time so as to reproduce the observations of ice crystal concentration. The time interval and chamber conditions over which ice nucleation occurs is therefore accurately known, and enables the model to be used as a test bed for different representations of ice formation
Prospective, open, multi-centre phase I/II trial to assess safety and efficacy of neoadjuvant radiochemotherapy with docetaxel and oxaliplatin in patients with adenocarcinoma of the oesophagogastric junction
Background: This phase I/II-trial assessed the dose-limiting toxicities (DLT) and maximum tolerated dose (MTD) of neoadjuvant radiochemotherapy (RCT) with docetaxel and oxaliplatin in patients with locally advanced adenocarcinoma of the oesophagogastric junction.
Methods: Patients received neoadjuvant radiotherapy (50.4 Gy) together with weekly docetaxel (20 mg/m2 at dose level (DL) 1 and 2, 25 mg/m2 at DL 3) and oxaliplatin (40 mg/m2 at DL 1, 50 mg/m2 at DL 2 and 3) over 5 weeks. The primary endpoint was the DLT and the MTD of the RCT regimen. Secondary endpoints included overall response rate (ORR) and progression-free survival (PFS).
Results: A total of 24 patients were included. Four patients were treated at DL 1, 13 patients at DL 2 and 7 patients at DL 3. The MTD of the RCT was considered DL 2 with docetaxel 20 mg/m2 and oxaliplatin 50 mg/m2. Objective response (CR/PR) was observed in 32% (7/22) of patients. Eighteen patients (75%) underwent surgery after RCT. The median PFS for all patients (n = 24) was 6.5 months. The median overall survival for all patients (n = 24) was 16.3 months. Patients treated at DL 2 had a median overall survival of 29.5 months.
Conclusion: Neoadjuvant RCT with docetaxel 20 mg/m2 and oxaliplatin 50 mg/m2 was effective and showed a good toxicity profile. Future studies should consider the addition of targeted therapies to current neoadjuvant therapy regimens to further improve the outcome of patients with advanced cancer of the oesophagogastric junction.
Trial Registration: NCT0037498
- …