Dietary nitrate enhances the contractile properties of human skeletal muscle

Dietary nitrate, a source of nitric oxide (NO), improves the contractile properties of human muscle. We present the hypothesis that this is due to nitrosylation of the ryanodine receptor and increased NO signaling via the soluble guanyl cyclase-cyclic guanosine monophosphate-protein kinase G pathway, which together increase the free intracellular Ca concentration along with the Ca sensitivity of the myofilaments themselves

From assimilation to biculturalism: Changing patterns in Maori-Pakeha relationships

This chapter examines the changing patterns of inter-ethnic relationships among Maori and Pakeha in New Zealand, specifically the moves from assimilation towards biculturalism. The impact of recent debate about the Treaty of Waitangi is described and examples of bicultural policies and their consequences are outlined

“Volunteering” to Arbitrate Through Predispute Arbitration Clauses: The Average Consumer’s Experience

This article helps build the empirical foundation necessary for an informed debate regarding arbitration clauses in consumer contracts by providing preliminary insight into how businesses\u27 use of these clauses affects consumers\u27 ability to pursue their legal rights. To this end, the article reports the results of a study investigating, in a wide variety of consumer purchases, the frequency with which the average consumer encounters arbitration clauses, the key provisions of these clauses, and the implications of these clauses for consumers who subsequently have disputes with businesses they patronize

Competition, Innovation and Racing for Priority at the U.S. Patent and Trademark Office

The U.S. Patent and Trademark Office resolves patent priority disputes in patent interference cases. Using a random sample of cases declared between 1988 and 1994, we establish a connection between patent interferences and patent races, and then use the data to consider some key issues in dynamic competition and innovation. We look at the incidence and distribution of patent races by technology, evidence for strategic delay of innovation by incumbent firms, and evidence that patent races moderate incentives to delay. Our results have implications for patent policy in general and for evaluating the U.S. “first to invent†patent priority rule.Patent race, Patent interference, US Board of Patent Appeals and Interferences, Patent litigation; Innovation; Research and development

Deregulation, Restructuring and Changing R&D Paradigms in the US Electric Utility Industry

This paper studies the impact of electricity deregulation and restructuring on research and development (R&D) expenditures of investor owned utilities. The differing pace of deregulation in the fifty states provides heterogeneity in institutional structure and competitive forces, and showcases the response of R&D funding to changing institutional environments. Based on a panel of all major investor-owned utilities from 1989-1997, this paper analyzes various political constraints, institutional change, and firm-specific financial and structural factors that have contributed to the decline of R&D expenditure in the U.S. electric utility industry. R&D is modeled as a two-stage process where firms first decide whether to invest in research depending on their critical mass and state characteristics, and then conditional on a positive decision, decide on the level of expenditure. A variation of the Heckman model is estimated in a panel data setting, allowing for separate effects of selection and intensity. The primary findings are: First, greater deregulation and competition has a positive effect on R&D whereas a higher probability of deregulation adversely affects research spending. The start date for retail competition and level and policies for stranded cost recovery do affect spending. Second, the response of R&D to financial and other firm attributes varies with the state of deregulation and provides insights into firm behavior in a regulated context. Third, the institutional and competitive factors interact in a way that suggest that full deregulation, coupled with effective retail competition may mitigate the problem of declining electricity R&D by the utilities.Electricity Deregulation, Competition, R&D

Evaluation of the Outpatients consultation in East Kent

CHSS undertook to support Kent and Medway Commissioning Support (KMCS: acting on behalf of East Kent Hospitals University NHS Foundation Trust and NHS Canterbury and Coastal Clinical Commissioning Group) in undertaking an independent analysis of a consultation on Outpatient services in East Kent. The aim of the consultation was to gain opinions from the public of a proposed Outpatient Clinical Strategy that intends to improve local access to, and facilities for, Outpatient services, and to offer a wider range of services on each site. CHSS advised on the survey, evaluated the consultation process, ran focus groups and carried out quantitative and qualitative analysis of the responses gathered during the consultation period (9th December 2013 to 17th March, 2014 - originally 9th March but period was extended). Ethical approval was not required for a consultation process, but ethical principles have been adhered to regarding data confidentiality and informed consent for the focus groups

A Solution to Concerns over Public Access to Scientific Data

To balance the public need for accountability and better policy decision making with concerns regarding burdens on scientists and scientific progress, the authors propose that increased access be limited to data relevant in analyzing regulations that would have an annual economic impact of at least $100 million. They also recommend establishing an agency to replicate key findings used to support regulations before they are finalized.Regulatory Reform

Should Researchers Be Required to Share Data Used in Supporting Regulatory Decisions?

The scientific establishment is deeply concerned over a proposed regulation that would require data to be shared on projects that are federally funded. Specifically, the proposed amendment to OMB Circular A-110 would require data collected by researchers at universities, hospitals, and non-profit institutions to be shared with interested parties if (1) the data are produced as part of a grant or agreement funded by the federal government; (2) the data are used in a published study; and (3) the data or study is used in formulating a policy or rule. Parties could request the data under the Freedom of Information Act. The proposed rule responds to a provision by Senator Richard Shelby in the 1999 Omnibus Spending Bill that requires data generated under federal awards at universities and non-profit institutions to be available to the public. This regulatory analysis develops an economic framework for evaluating proposals to provide greater access to research data. Our analysis also offers specific recommendations for improving OMB Circular A-110 as well as the broader regulatory process. We argue that the economic analysis of sharing research findings can be separated into three parts: the impact of requiring public access on incentives to produce data, research, and innovation; the impact of that requirement on the quality of research; and the impact of required access on the efficiency and transparency of policy. The economic analysis demonstrates that the standard property-rights framework used to justify time-limited property rights for the use of data is not sufficient for addressing broader problems in which research and data could be used to help inform public policy decisions. The value of sharing data for public policy must also be considered. A second conclusion is that traditional peer review done by scientific journals is not adequate for purposes of relying on research for major public policy decisions. A third conclusion is that scientists who are reluctant to share their findings are more likely to have errors in their analysis than the average researcher. A fourth conclusion is that requiring the release of data could slow the development of data and delay the publication of results. Although substantial costs and uncertainty may be associated with greater public access to data, our analysis suggests that academic norms alone provide very limited access to scientific data. We recommend improving Circular A-110 by narrowing and clarifying the scope of the proposed regulation. The proposed regulation should apply to economically significant regulations that have an annual economic impact of at least $100 million. In addition, we recommend that Congress create an agency that would be charged with replicating the findings of regulatory agencies before such regulations could be implemented. The recommendations concerning replication would require additional legal authority. Taken together, our recommendations would help lay the foundation for a regulatory system that is more accountable and has more scientific integrity.