12,502 research outputs found
Development of a machine protection system for the Superconducting Beam Test Facility at Fermilab
Fermilab's Superconducting RF Beam Test Facility currently under construction
will produce electron beams capable of damaging the acceleration structures and
the beam line vacuum chambers in the event of an aberrant accelerator pulse.
The accelerator is being designed with the capability to operate with up to
3000 bunches per macro-pulse, 5Hz repetition rate and 1.5 GeV beam energy. It
will be able to sustain an average beam power of 72 KW at the bunch charge of
3.2 nC. Operation at full intensity will deposit enough energy in niobium
material to approach the melting point of 2500 {\deg}C. In the early phase with
only 3 cryomodules installed the facility will be capable of generating
electron beam energies of 810 MeV and an average beam power that approaches 40
KW. In either case a robust Machine Protection System (MPS) is required to
mitigate effects due to such large damage potentials. This paper will describe
the MPS system being developed, the system requirements and the controls issues
under consideration.Comment: 3 pp. 13th International Conference on Accelerator and Large
Experimental Physics Control Systems (ICALEPCS 2011). 10-14 Oct 2011.
Grenoble, Franc
Smoking, dementia and cognitive decline in the elderly, a systematic review.
Background. Nicotine may aid reaction time, learning and memory, but smoking increases cardiovascular risk. Cardiovascular risk factors have been linked to increased risk of dementia. A previous meta-analysis found that current smokers were at higher risk of subsequent dementia, Alzheimers disease, vascular dementia and cognitive decline. Methods. In order to update and examine this further a systematic review and meta-analysis was carried out using different search and inclusion criteria, database selection and more recent publications. Both reviews were restricted to those aged 65 and over. Results. The review reported here found a significantly increased risk of Alzheimers disease with current smoking and a likely but not significantly increased risk of vascular dementia, dementia unspecified and cognitive decline. Neither review found clear relationships with former smoking. Conclusion. Current smoking increases risk of Alzheimers disease and may increase risk of other dementias. This reinforces need for smoking cessation, particularly aged 65 and over. Nicotine alone needs further investigation. © 2008 Peters et al; licensee BioMed Central Ltd
Finite element solution of low bond number sloshing
The dynamics of liquid propellant in a low Bond number environment which are critical to the design of spacecraft systems with respect to orbital propellant transfer and attitude control system were investigated. Digital computer programs were developed for the determination of liquid free surface equilibrium shape, lateral slosh natural vibration mode shapes, and frequencies for a liquid in a container of arbitrary axisymmetric shape with surface tension forces the same order of magnitude as acceleration forces. A finite volume element representation of the liquid was used for the vibration analysis. The liquid free surface equilibrium shapes were computed for several tanks at various contact angles and ullage volumes. A configuration was selected for vibration analysis and lateral slosh mode shapes and natural frequencies were obtained. Results are documented
Smectic-C tilt under shear in Smectic-A elastomers
Stenull and Lubensky [Phys. Rev. E {\bf 76}, 011706 (2007)] have argued that
shear strain and tilt of the director relative to the layer normal are coupled
in smectic elastomers and that the imposition of one necessarily leads to the
development of the other. This means, in particular, that a Smectic-A elastomer
subjected to a simple shear will develop Smectic-C-like tilt of the director.
Recently, Kramer and Finkelmann [arXiv:0708.2024, Phys. Rev. E {\bf 78}, 021704
(2008)] performed shear experiments on Smectic-A elastomers using two different
shear geometries. One of the experiments, which implements simple shear,
produces clear evidence for the development of Smectic-C-like tilt. Here, we
generalize a model for smectic elastomers introduced by Adams and Warner [Phys.
Rev. E {\bf 71}, 021708 (2005)] and use it to study the magnitude of
Smectic-C-like tilt under shear for the two geometries investigated by Kramer
and Finkelmann. Using reasonable estimates of model parameters, we estimate the
tilt angle for both geometries, and we compare our estimates to the
experimental results. The other shear geometry is problematic since it
introduces additional in-plane compressions in a sheet-like sample, thus
inducing instabilities that we discuss.Comment: 8 pages, 5 figure
Computational challenges of systems biology
Progress in the study of biological systems such as the heart, brain, and liver will require computer scientists to work closely with life scientists and mathematicians. Computer science will play a key role in shaping the new discipline of systems biology and addressing the significant computational challenges it poses
Quantification of contaminants associated with LDEF
The quantification of contaminants on the Long Duration Exposure Facility (LDEF) and associated hardware or tools is addressed. The purpose of this study was to provide a background data base for the evaluation of the surface of the LDEF and the effects of orbital exposure on that surface. This study necessarily discusses the change in the distribution of contaminants on the LDEF with time and environmental exposure. Much of this information may be of value for the improvement of contamination control procedures during ground based operations. The particulate data represents the results of NASA contractor monitoring as well as the results of samples collected and analyzed by the authors. The data from the tapelifts collected in the Space Shuttle Bay at Edwards Air Force Base and KSC are also presented. The amount of molecular film distributed over the surface of the LDEF is estimated based on measurements made at specific locations and extrapolated over the surface area of the LDEF. Some consideration of total amount of volatile-condensible materials available to form the resultant deposit is also presented. All assumptions underlying these estimates are presented along with the rationale for the conclusions. Each section is presented in a subsection for particles and another for molecular films
Analysis of combustion instability in liquid propellant engines with or without acoustic cavities
Analytical studies have been made of the relative combustion stability of various propellant combinations when used with hardware configurations representative of current design practices and with or without acoustic cavities. Two combustion instability models, a Priem-type model and a modification of the Northern Research and Engineering (NREC) instability model, were used to predict the variation in engine stability with changes in operating conditions, hardware characteristics or propellant combination, exclusive of acoustic cavity effects. The NREC model was developed for turbojet engines but is applicable to liquid propellant engines. A steady-state combustion model was used to predict the needed input for the instability models. In addition, preliminary development was completed on a new model to predict the influence of an acoustic cavity with specific allowance for the effects the nozzle, steady flow and combustion
In vitro induction of tumour-specific immunity V. Detection of common antigenic determinatnts of murine fibrosarcomas.
Two 3-methylcholanthrene and a spontaneous BALB/c fibrosarcoma were examined for tumour-associated antigens (TAA) by in vivo and in vitro induction of tumour-immune responses. When BALB/c mice were immunized to these fibrosarcomas by surgical tumour removal, cross-reacting tumour-associated transplantation antigens (TATA) were detected on all 3 tumours. Cytotoxic effector cells (CL) were then induced in vitro by co-culture of BALB/c spleen cells with the spontaneous, or one of the carcinogen-induced fibrosarcomas. These CL were shown to be cytotoxic T cells (Tc) and to be directed against cross-reacting TAA on all 3 tumours, by two in vitro 51Cr-release assay systems, direct 51Cr-release cytotoxicity and cellular competitive inhibition of 51Cr release. Further studies demonstrated that the fibrosarcoma TAA involved in in vitro induction of Tc were not present on normal adult or foetal tissues. A secondary cytotoxic response was also detected in vitro when spleen cells from mice immunized to a carcinogen-induced fibrosarcoma were tested. The patterns of cross-reactivity detected by the in vivo and primary in vitro tumour-immune responses suggested that the TAA detected in vivo (TATA) were not identical to the TAA detected in vitro
COMMUNITY SUPPORTED AGRICULTURE: FILLING A NICHE MARKET
In less than a decade, the number of Community Supported Agriculture (CSA) projects has grown to more than 400. Our research suggests that CSA shareholders' social objectives dominate their decision to join. Standard economic objectives and "club-related" objectives contribute to the decision, but are clearly secondary. Our research also suggests the CSA movement will continue to grow. Its emphasis on social objectives, its inability to supply food year around, and the ongoing development of size-neutral organic technologies, however, will probably keep it from becoming a major market channel in the next century.Agribusiness,
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