Causality and replication in concurrent processes

The replication operator was introduced by Milner for obtaining a simplified description of recursive processes. The standard interleaving semantics denotes the replication of a process P, written !P, a shorthand for its unbound parallel composition, operationally equivalent to the process P | P | …, with P repeated as many times as needed. Albeit the replication mechanism has become increasingly popular, investigations on its causal semantics has been scarce. In fact, the correspondence between replication and unbound parallelism makes it difficult to recover basic properties usually associated with these semantics, such as the so-called concurrency diamond. In this paper we consider the interleaving semantics for the operator proposed by Sangiorgi and Walker, and we show how to refine it in order to capture causality. Furthermore, we prove it coincident with the standard causal semantics for recursive process studied in the literature, for processes defined by means of constant invocations

Measurement of kinematic and nuclear dependence of R = σ_L/σ_T in deep inelastic electron scattering

We report results on a precision measurement of the ratio R=σ_L/σ_T in deep inelastic electron-nucleon scattering in the kinematic range 0.2≤x≤0.5 and 1≤Q^2≤10 (GeV/c)^2. Our results show, for the first time, a clear falloff of R with increasing Q^2. Our R results are in agreement with QCD predictions only when corrections for target mass effects and some additional higher twist effects are included. At small x, the data on R favor structure functions with a large gluon contribution. We also report results on the differences R_A-R_D and the cross section ratio σ^A/σ^D between Fe and Au nuclei and the deuteron. Our results for R_A-R_D are consistent with zero for all x, Q^2 indicating that possible contributions to R from nuclear higher twist effects and spin-0 constituents in nuclei are not different from those in nucleons. The ratios σ^A/σ^D from all recent experiments, at all x, Q^2 values, are now in agreement

Measurement of the Difference in R=σ_L/σ_T and of σ^A/σ^D in Deep-Inelastic e-D, e-Fe, and e-Au Scattering

We measured the differences in R=σ_L/σ_T and the cross-section ratio σA/σD in deep-inelastic electron scattering from D, Fe, and Au nuclei in the kinematic range 0.2≤x≤0.5 and 1≤Q^2≤5 (Gev/c)^2. Our results for R^A-R^D are consistent with zero for all x and Q^2, indicating that possible contributions to R from nuclear higher-twist effects and spin-0 constituents in nuclei are not different from those in nucleons. The European Muon Collaboration effect is reconfirmed, and the low-x data from all recent experiments, at all Q^2, are now in agreement

Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53 independent pathways

Most cancer cells use aerobic glycolysis to fuel their growth. The enzyme lactate dehydrogenase-A (LDH-A) is key to cancer’s glycolytic phenotype, catalysing the regeneration of nicotinamide adenine dinucleotide (NAD þ ) from reduced nicotinamide adenine dinucleotide (NADH) necessary to sustain glycolysis. As such, LDH-A is a promising target for anticancer therapy. Here we ask if the tumour suppressor p53, a major regulator of cellular metabolism, influences the response of cancer cells to LDH-A suppression. LDH-A knockdown by RNA interference (RNAi) induced cancer cell death in p53 wild-type, mutant and p53-null human cancer cell lines, indicating that endogenous LDH-A promotes cancer cell survival irrespective of cancer cell p53 status. Unexpectedly,however,weuncoveredanovelroleforp53intheregulationofcancercellNADþ anditsreducedformNADH.Thus, LDH-A silencing by RNAi, or its inhibition using a small-molecule inhibitor, resulted in a p53-dependent increase in the cancer cell ratioofNADH:NADþ.Thiseffectwasspecificforp53þ/þ cancercellsandcorrelatedwith(i)reducedactivityofNADþ-dependent deacetylase sirtuin 1 (SIRT1) and (ii) an increase in acetylated p53, a known target of SIRT1 deacetylation activity. In addition, activation of the redox-sensitive anticancer drug EO9 was enhanced selectively in p53 þ / þ cancer cells, attributable to increased activity of NAD(P)H-dependent oxidoreductase NQO1 (NAD(P)H quinone oxidoreductase 1). Suppressing LDH-A increased EO9-inducedDNAdamageinp53þ/þ cancercells,butimportantlyhadnoadditiveeffectinnon-cancercells.Ourresultsidentifya unique strategy by which the NADH/NADþ cellular redox status can be modulated in a cancer-specific, p53-dependent manner and we show that this can impact upon the activity of important NAD(H)-dependent enzymes. To summarise, this work indicates two distinct mechanisms by which suppressing LDH-A could potentially be used to kill cancer cells selectively, (i) through induction of apoptosis, irrespective of cancer cell p53 status and (ii) as a part of a combinatorial approach with redox-sensitive anticancer drugs via a novel p53/NAD(H)-dependent mechanism

Remarkable change of tunneling conductance in YBCO films in fields up to 32.4T

We studied the tunneling density of states in YBCO films under strong currents flowing along node directions. The currents were induced by fields of up to 32.4T parallel to the film surface and perpendicular to the $CuO_{2}$ planes. We observed a remarkable change in the tunneling conductance at high fields where the gap-like feature shifts discontinuously from 15meV to a lower bias of 11meV, becoming more pronounced as the field increases. The effect takes place in increasing fields around 9T and the transition back to the initial state occurs around 5T in decreasing fields. We argue that this transition is driven by surface currents induced by the applied magnetic field.Comment: 4 pages, 7 figure

Sigref – A Symbolic Bisimulation Tool Box

We present a uniform signature-based approach to compute the most popular bisimulations. Our approach is implemented symbolically using BDDs, which enables the handling of very large transition systems. Signatures for the bisimulations are built up from a few generic building blocks, which naturally correspond to efficient BDD operations. Thus, the definition of an appropriate signature is the key for a rapid development of algorithms for other types of bisimulation. We provide experimental evidence of the viability of this approach by presenting computational results for many bisimulations on real-world instances. The experiments show cases where our framework can handle state spaces efficiently that are far too large to handle for any tool that requires an explicit state space description. This work was partly supported by the German Research Council (DFG) as part of the Transregional Collaborative Research Center “Automatic Verification and Analysis of Complex Systems” (SFB/TR 14 AVACS). See www.avacs.org for more information

Graphical Encoding of a Spatial Logic for the pi-Calculus

This paper extends our graph-based approach to the verification of spatial properties of π-calculus specifications. The mechanism is based on an encoding for mobile calculi where each process is mapped into a graph (with interfaces) such that the denotation is fully abstract with respect to the usual structural congruence, i.e., two processes are equivalent exactly when the corresponding encodings yield isomorphic graphs. Behavioral and structural properties of π-calculus processes expressed in a spatial logic can then be verified on the graphical encoding of a process rather than on its textual representation. In this paper we introduce a modal logic for graphs and define a translation of spatial formulae such that a process verifies a spatial formula exactly when its graphical representation verifies the translated modal graph formula