907 research outputs found
Operational reliability assessment of the GEOS A spacecraft
Decision theory application to GEOS A spacecraft operational reliability assessmen
Origin of Native Driving Force in Protein Folding
We derive an expression with four adjustable parameters that reproduces well
the 20x20 Miyazawa-Jernigan potential matrix extracted from known protein
structures. The numerical values of the parameters can be approximately
computed from the surface tension of water, water-screened dipole interactions
between residues and water and among residues, and average exposures of
residues in folded proteins.Comment: LaTeX file, Postscript file; 4 pages, 1 figure (mij.eps), 2 table
Positive expectations predict improved mental-health outcomes linked to psychedelic microdosing
Psychedelic microdosing describes the ingestion of near-threshold perceptible doses of classic psychedelic substances. Anecdotal reports and observational studies suggest that microdosing may promote positive mood and well-being, but recent placebo-controlled studies failed to fnd compelling evidence for this. The present study collected web-based mental health and related data using a prospective (before, during and after) design. Individuals planning a weekly microdosing regimen completed surveys at strategic timepoints, spanning a core four-week test period. Eightyone participants completed the primary study endpoint. Results revealed increased self-reported psychological well-being, emotional stability and reductions in state anxiety and depressive symptoms at the four-week primary endpoint, plus increases in psychological resilience, social connectedness, agreeableness, nature relatedness and aspects of psychological fexibility. However, positive expectancy scores at baseline predicted subsequent improvements in well-being, suggestive of a signifcant placebo response. This study highlights a role for positive expectancy in predicting positive outcomes following psychedelic microdosing and cautions against zealous inferences on its putative therapeutic value
The future of enterprise groupware applications
This paper provides a review of groupware technology and products. The purpose of this review is to investigate the appropriateness of current groupware technology as the basis for future enterprise systems and evaluate its role in realising, the currently emerging, Virtual Enterprise model for business organisation. It also identifies in which way current technological phenomena will transform groupware technology and will drive the development of the enterprise systems of the future
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On the role of goal relevance in emotional attention: Disgust evokes early attention to cleanliness
Prior evidence has shown that aversive emotional states are characterised by an attentional bias
towards aversive events. The present study investigated whether aversive emotions also bias attention
towards stimuli that represent means by which the emotion can be alleviated. We induced disgust by
having participants touch fake disgusting objects. Participants in the control condition touched nondisgusting
objects. The results of a subsequent dot-probe task revealed that attention was oriented to
disgusting pictures irrespective of condition. However, participants in the disgust condition also
oriented towards pictures representing cleanliness. These findings suggest that the deployment of
attention in aversive emotional states is not purely stimulus driven but is also guided by the goal to
alleviate this emotional state
MOLECULAR STRUCTURE OF THE EPIDERMAL EXTRACELLULAR SPACES
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65966/1/j.1365-4362.1979.tb01946.x.pd
On Saint-Venant's principle in plane anisotropic elasticity
Methods involving energy-decay inequalities are applied in investigating Saint-Venant's principle for the planproblem of linear elastostatics for a wide class of anisotropic media. A lower bound (in terms of the elastic constants) is obtained for the rate of exponential decay of stresses and this is compared with the known result for the isotropic case. Par une méthode applicable à un très grand nombre de milieu anisotropique, l'auteur utilise les inégalités concernant la décroissance de l'énergie dans le cas d'un problème plan et dans l'hypothèse de conditions élastostatiques linéaires, l'auteur précise la validité du principe de Saint-Venant dans le cadre de ses applications. Une limite inférieure (en fonction des constantes élastiques) de la décroissance exponentielle des contraintes est mise en évidence et comparée aux résultats obtenus en milieux isotropes.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42676/1/10659_2004_Article_BF00125525.pd
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