Internet-based framework to support integration of the customer in the design of customizable products

Integration of customers is a necessary element to design and produce customer centric products. Design tools and methodologies need to be altered to accommodate customers into the process of designing customized products. In the current paper a mass customization framework is presented, that uses computer-aided design (CAD) and finiteelement-based optimization tools to integrate the customer into the design process via the internet. A mass customization template for generating optimized user-customized products is also presented. The capability of the system is demonstrated by a case study on customization of bicycle frames.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

Tissue Culture in Microgravity

Attempts to simulate normal tissue micro-environments in vitro have been thwarted by the complexity and plasticity of the extracellular matrix, which is important in regulating cytoskeletal and nuclear matrix proteins. Gravity is one of the problems, tending to separate components that should be kept together. For space shuttle experiments, NASA engineers devised a double-walled rotating bioreactor, which is proving to be a useful tissue culture device on earth as well as in space

Internet-based Framework to Support Integration of Customer in the Design of Customizable Products

A necessary element to design and produce customer-centric products is the integration of customers in the design process. Challenges faced during customer integration into the design process include generating models of the customized product, performing analysis of these to determine feasibility, and optimizing to increase the performance. These tasks have to be performed relatively quickly, if not in real time, to provide feedback to the customer. The focus of this article is to present a framework that utilizes CAD, finite element analysis (FEA), and optimization to integrate the customer into the design process via the Internet for delivering user customized products. The design analysis, evaluation, and optimization need to be automated and enhanced to enable operation over the Internet. A product family CAD/FEA template has been developed to perform analysis, along with a general formulation to optimize the customized product. The CAD/FEA template generalizes the geometry building and analysis of each configuration developed using a product platform approach. The proposed setup is demonstrated through the use of a bicycle frame family. In this study, the focus is on the application of optimization and FEA to facilitate the design of customer-centric products.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

Submarine groundwater springs are characterized by distinct fish communities

The inflow of terrestrial groundwater into the ocean is increasingly recognized as an important local source of nutrients and pollutants to coastal ecosystems. Although there is evidence of a link between fresh submarine groundwater discharge (SGD)‐derived nutrients and primary producer and primary consumer abundances, the effects of fresh SGD on the productivity of higher trophic levels such as ichthyofaunal communities remain unclear. To further investigate this relationship, we sampled three sites inside a coral reef lagoon in Mauritius: One site entailing six distinct groundwater springs, a site highly influenced by freshwater influx through the springs, and a strictly marine control site. Using remote underwater video surveys, we found that fish abundances were significantly higher at the groundwater springs than at the other two sampling sites.Principal component analyses showed that the springs and the spring‐influenced part of the lagoon were best described by elevated water nutrient loadings, whereas the control site was characterized by higher water salinity and pH. Macroalgae cover was highest at the control site and the springs. Herbivores and invertivores dominated the fish community at the springs, in contrast to generalists at the control site. At the spring‐influenced site, we mainly encountered high coral/turf algae cover and high abundances of associated fish feeding groups (territorial farmers, corallivores). Our results provide evidence of a fresh SGD‐driven relationship between altered hydrography and distinct fish communities with elevated abundances at groundwater springs in a coral reef lagoon. These findings suggest that the management and assessment of secondary consumer productivity in tropical lagoons should take into account the effects of groundwater springs

The Prevalence of Human Papillomavirus in Pediatric Tonsils: a Systematic Review of the Literature

BACKGROUND: HPV-related head and neck cancer rates have been increasing in recent years, with the tonsils being the most commonly affected site. However, the current rate of HPV infection in the pediatric population remains poorly defined. The objective of this study was to systematically review and evaluate the prevalence and distribution of HPV in the tonsils of pediatric patients undergoing routine tonsillectomy. METHODS AND RESULTS: The literature was searched using PubMed, EMBASE, Scopus, CINAHL, Cochrane Library, and ProQuest Dissertations & Theses Global databases (inception to December 2017) by two independent review authors. Inclusion criteria included articles which evaluated the prevalence of HPV in a pediatric cohort without known warts or recurrent respiratory papillomatosis, those which used tonsil biopsy specimens for analysis, and those with six or more subjects and clear outcomes reported. Eleven studies met the inclusion criteria. Using the Oxford Clinical Evidence-based Medicine (OCEBM) guidelines, two reviewers appraised the level of evidence of each study, extracted data, and resolved discrepancies by consensus. The systematic review identified 11 articles (n = 2520). Seven studies detected HPV in the subject population, with prevalence values ranging from 0 to 21%. The level of evidence for all included studies was OCEBM Level 3. CONCLUSIONS: HPV may be present in pediatric tonsillectomy specimens; however, the largest included study demonstrated a prevalence of 0%. Future testing should be performed using methods with high sensitivities and specificities, such as reverse transcript real-time PCR or digital droplet PCR

Calculating Stage Duration Statistics in Multistage Diseases

Many human diseases are characterized by multiple stages of progression. While the typical sequence of disease progression can be identified, there may be large individual variations among patients. Identifying mean stage durations and their variations is critical for statistical hypothesis testing needed to determine if treatment is having a significant effect on the progression, or if a new therapy is showing a delay of progression through a multistage disease. In this paper we focus on two methods for extracting stage duration statistics from longitudinal datasets: an extension of the linear regression technique, and a counting algorithm. Both are non-iterative, non-parametric and computationally cheap methods, which makes them invaluable tools for studying the epidemiology of diseases, with a goal of identifying different patterns of progression by using bioinformatics methodologies. Here we show that the regression method performs well for calculating the mean stage durations under a wide variety of assumptions, however, its generalization to variance calculations fails under realistic assumptions about the data collection procedure. On the other hand, the counting method yields reliable estimations for both means and variances of stage durations. Applications to Alzheimer disease progression are discussed