An advanced brushless dc torque motor Quarterly report, 30 Sep. - 30 Dec. 1966

Design of torque motor controller, and operation of breadboard control circui

Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2.

Vertebrates produce multiple chondroitin sulfate proteoglycans that play important roles in development and tissue mechanics. In the nematode Caenorhabditis elegans, the chondroitin chains lack sulfate but nevertheless play essential roles in embryonic development and vulval morphogenesis. However, assignment of these functions to specific proteoglycans has been limited by the lack of identified core proteins. We used a combination of biochemical purification, Western blotting, and mass spectrometry to identify nine C. elegans chondroitin proteoglycan core proteins, none of which have homologues in vertebrates or other invertebrates such as Drosophila melanogaster or Hydra vulgaris. CPG-1/CEJ-1 and CPG-2 are expressed during embryonic development and bind chitin, suggesting a structural role in the egg. RNA interference (RNAi) depletion of individual CPGs had no effect on embryonic viability, but simultaneous depletion of CPG-1/CEJ-1 and CPG-2 resulted in multinucleated single-cell embryos. This embryonic lethality phenocopies RNAi depletion of the SQV-5 chondroitin synthase, suggesting that chondroitin chains on these two proteoglycans are required for cytokinesis

Density-functional investigation of the rhombohedral to simple cubic phase transition of arsenic

We report on our investigation of the crystal structure of arsenic under compression, focusing primarily on the pressure-induced A7 to simple cubic (sc) phase transition. The two-atom rhombohedral unit cell is subjected to pressures ranging from 0 GPa to 200 GPa; for each given pressure, cell lengths and angles, as well as atomic positions, are allowed to vary until the fully relaxed structure is obtained. We find that the nearest and next-nearest neighbor distances give the clearest indication of the occurrence of a structural phase transition. Calculations are performed using the local density approximation (LDA) and the PBE and PW91 generalized gradient approximations (GGA-PBE and GGA-PW91) for the exchange-correlation functional. The A7 to sc transition is found to occur at 21+/-1 GPa in the LDA, at 28+/-1 GPa in the GGA-PBE and at 29+/-1 GPa in the GGA-PW91; no volume discontinuity is observed across the transition in any of the three cases. We use k-point grids as dense as 66X66X66 to enable us to present reliably converged results for the A7 to sc transition of arsenic.Comment: To be published in Physical Review B; material supplementary to this article is available at arXiv:0810.169

A self-adapting latency/power tradeoff model for replicated search engines

For many search settings, distributed/replicated search engines deploy a large number of machines to ensure efficient retrieval. This paper investigates how the power consumption of a replicated search engine can be automatically reduced when the system has low contention, without compromising its efficiency. We propose a novel self-adapting model to analyse the trade-off between latency and power consumption for distributed search engines. When query volumes are high and there is contention for the resources, the model automatically increases the necessary number of active machines in the system to maintain acceptable query response times. On the other hand, when the load of the system is low and the queries can be served easily, the model is able to reduce the number of active machines, leading to power savings. The model bases its decisions on examining the current and historical query loads of the search engine. Our proposal is formulated as a general dynamic decision problem, which can be quickly solved by dynamic programming in response to changing query loads. Thorough experiments are conducted to validate the usefulness of the proposed adaptive model using historical Web search traffic submitted to a commercial search engine. Our results show that our proposed self-adapting model can achieve an energy saving of 33% while only degrading mean query completion time by 10 ms compared to a baseline that provisions replicas based on a previous day's traffic

Response to: "Renal biopsies should be performed whenever treatment strategies depend on renal involvement"

We thank Chemouny et al for their letter and concur with their conclusions. As we state (1): “A positive biopsy for AAV is helpful when considering an initial diagnosis or recurrent disease.” In our view, renal biopsy is important to establish diagnosis and may also provide an indication of prognostic trajectory and although existing classification systems need further validation, changes like glomerular sclerosis have obvious adverse prognostic value for patients with AAV (2-4). The Delphi process, for the scope of the current recommendations, identified the role of biopsy at both diagnosis and follow-up as an important item for update. Histopathological evidence of vasculitis, such as pauci-immune glomerulonephritis or necrotising vasculitis in any organ, remains the gold standard for diagnostic purposes. The likely diagnostic yield varies and is dependent on the organ targeted and in patients with GPA with renal involvement can be as high as 91.5% from renal biopsy (5). As Chemouny and colleagues have demonstrated, a renal biopsy was definitive in determining their management decisions. However during follow-up when relapses occur, it may be prudent to consider judicious use of further kidney biopsy during suspected renal relapse since the cause for acute kidney injury may be due to another cause other than AAV (6). Kind regards, M Yates, C Mukhtyar and DR Jayne on behalf of co-authors

Development of a carbon fibre composite active mirror: Design and testing

Carbon fibre composite technology for lightweight mirrors is gaining increasing interest in the space- and ground-based astronomical communities for its low weight, ease of manufacturing, excellent thermal qualities and robustness. We present here first results of a project to design and produce a 27 cm diameter deformable carbon fibre composite mirror. The aim was to produce a high surface form accuracy as well as low surface roughness. As part of this programme, a passive mirror was developed to investigate stability and coating issues. Results from the manufacturing and polishing process are reported here. We also present results of a mechanical and thermal finite element analysis, as well as early experimental findings of the deformable mirror. Possible applications and future work are discussed.Comment: Accepted by Optical Engineering. Figures 1-7 on http://www.star.ucl.ac.uk/~sk/OEpaper_files