The entrepreneurial subjectivity of successful researchers

This article begins the work of examining what kind of doctoral experiences positively influence researcher development, and what other attributes may contribute to a successful research career. It reports preliminary findings from the analysis of survey responses by a sample of successful mid-career researchers. Positive doctoral experiences and the early establishment of research activity are found to be important to researcher development. Successful researchers were also found to be able to acknowledge the importance of their 'soft skills', and to have flexible, responsive and adaptive dispositions. We term this disposition 'an entrepreneurial subjectivity' and argue that it is an important and underexamined characteristic of the successful researcher

Displaced mothers: Birth and resettlement, gratitude and complaint

In narratives of displaced Karen women from Burma, both before and after resettlement in Australia, women framed their birthing experiences with those of persecution and displacement. Although grateful for the security of resettlement in Australia, social inclusion was negligible and women's birthing experiences occurred in that context. Women described the impact of the lack of interpreting services in Australian hospitals and an absence of personal and communal care that they expected. Frequently, this made straightforward births confusing or difficult, and exacerbated the distress of more complicated births. Differences in individual responses related to women's histories, with younger women displaying more preparedness to complain and identify discrimination. The problems identified with health care, coupled with the inability of many of the women to complain requires attention, not just within the health-care system, but more widely as part of social attitudes concerning Australia's obligations to those who seek asylum

Independence interrupted: creativity, context and the 'independent scholar'

Social and networked conceptions of creativity highlight the key role of collaboration and connection making in the work involved in creating and imagining new knowledge. With governments around the world keen to harness the potential of research to foster innovation and economic growth, the question arises as to whether the research degree experience is preparing graduates to be creative, or mobilise creativity, in this way. In this chapter we explore this issue through examining the persistent figure of the 'independent scholar' in accounts of research education and practice. We draw on preliminary analysis of data collected on the role of the doctorate in mid-career research success based on a survey of Australian Research Council Future Fellowship recipients. Our analysis focuses on responses to two open ended questions concerning; a) to what respondents' attribute their mid-career research sucess, and d) the extent to which the PhD experience provides preparation for a research career. We identify intriguing tensions and contradictions in the ways in which being and becoming a successful researcher are conceived. Most notably, the findings suggest that success can be achieved through different modes of working - and being trained - as a researcher. These have implications for universities seeking to promote research collaboration and creativity

'These are issues that should not be raised in black and white': the culture of progress reporting and the doctorate

This paper reports findings from Australian research into student, academic and administrative staff understandings of the role and efficacy of periodic progress reports designed to monitor the progress of higher-degree-by-research candidates. Major findings are that confusion of the purpose and ultimate audience of these reports is linked to less than effective reporting by all parties; countersigning and report dependency requirements inhibit the frank reporting of progress and 'social learning' impacts on the way candidates and sometimes supervisors approach reporting obligations, running counter to institutional imperatives. We conclude that no ready or transparent nexus between the progress report and progress may be assumed. Fundamentally, this calls into question the usefulness of this process as currently implemented. Arising from this is the recommendation that progress reporting be linked to substantive reviews of progress and embedded in the pedagogy and curriculum of higher-degree-by-research programmes

Strong "quantum" chaos in the global ballooning mode spectrum of three-dimensional plasmas

The spectrum of ideal magnetohydrodynamic (MHD) pressure-driven (ballooning) modes in strongly nonaxisymmetric toroidal systems is difficult to analyze numerically owing to the singular nature of ideal MHD caused by lack of an inherent scale length. In this paper, ideal MHD is regularized by using a $k$-space cutoff, making the ray tracing for the WKB ballooning formalism a chaotic Hamiltonian billiard problem. The minimum width of the toroidal Fourier spectrum needed for resolving toroidally localized ballooning modes with a global eigenvalue code is estimated from the Weyl formula. This phase-space-volume estimation method is applied to two stellarator cases.Comment: 4 pages typeset, including 2 figures. Paper accepted for publication in Phys. Rev. Letter

Exploring researcher motivation: Implications for PhD education

Demand exists globally for a research labour force both willing and able to drive innovation and social and economic advancement. Researcher productivity and retention are thus significant issues. This chapter reports on research into factors influencing mid-career researcher productivity with a focus on researcher motivation. It is based on a survey of Australian Research Council awarded Future Fellowship recipients. The findings suggest that research motivations encompass either the 'who' (Personal), the 'what/how' (Process) or the 'why' (Outcomes). For a surprising proportion of respondents (43%), research outcomes do not feature in their motivations. The dominance, within this sample, of personal and affective motivations to do research is at odds with the 'nation-building' objectives of the scheme that funds them. We exp-lore the implications of the apparently weak alignment between researcher motivation and objectives of funding scheme and innovation system more broadly

Identification of senescent cells in multipotent mesenchymal stromal cell cultures: Current methods and future directions

Regardless of their tissue of origin, multipotent mesenchymal stromal cells (MSCs) are commonly expanded in vitro for several population doublings, in order to achieve a sufficient number of cells for therapy. Prolonged MSC expansion has shown to result in phenotypical, morphological and gene expression changes in MSCs, which ultimately lead to the state of senescence. The presence of senescent cells in therapeutic MSC batches is undesirable, as it reduces their viability, differentiation potential and trophic capabilities. Additionally, senescent cells acquire senescence-activated secretory phenotype, which may not only induce apoptosis in the neighbouring host cells following MSC transplantation, but also trigger local inflammatory reactions. This review outlines the current and promising new methodologies for the identification of senescent cells in MSC cultures, with a particular emphasis on non-destructive and label-free methodologies. Technologies allowing identification of individual senescent cells, based on new surface markers, offer potential advantage for targeted senescent cell removal using new-generation senolytic agents, and subsequent production of therapeutic MSC batches fully devoid of senescent cells. Methods or a combination of methods that are non-destructive and label-free, for example involving cell size and spectroscopic measurements, could be the best way forward as they do not modify the cells of interest thus maximising the final output of therapeutic-grade MSC cultures. The further incorporation of machine learning methods has also recently shown promise in facilitating, automating and enhancing the analysis of these measured data

Masswe Colonic Haemorrhage from a Solitary Caecal Varix

A 51 year old lady with chronic active hepatitis presented with massive lower gastrointestinal tract bleeding. Angiography demonstrated a solitary varix in the caecum which was found at laparotomy to be entering the bowel wall at the site ofadhesions from a previous appendicectomy. The portal pressure was found to be raised. Aright hemicolectomy stopped the blood loss, but she subsequently died ofliver failure. Solitary colonic varices associated with adhesions are extremely rare and their optimal management has not been established

Enrichment and preserved functionality of multipotential stromal cells in bone marrow concentrate processed by vertical centrifugation

The concentration of bone marrow (BM) aspirate (BMA) is increasingly valued for bone and cartilage repair, particularly with the rarity and donor-variability of BM-multipotential stromal cells (BM-MSCs). The present study aimed to assess BM-MSC yield following BM concentration using a fast and compact-sized vertical centrifugation system. BMA concentrate (BMAC) was separated in a 1 min process and collected easily after an automatic discarding of plasma and red blood cells. A significant increase in CD45low CD271high cells per BMAC volume (measured using flow-cytometry) was noted (4-fold, p = 0.0001). Additionally, the vertical centrifugation system helped to enrich colony numbers (assessed by CFU-F assays) in BMAC comparably with conventional centrifugation systems, BioCUE™ and SmartPReP-2® (4.3-fold, 4.6-fold and 3-fold, respectively). Next, a functional assessment of BM-MSCs processed by vertical centrifugation was performed, and MSC viability and proliferation were not affected. Also, these BM-MSCs showed similar alkaline phosphatase and calcium levels to those of BMA-MSCs when osteogenically induced. Furthermore, glycosaminoglycans and Nile red levels in addition to the gene expression assays confirmed that there was no significant change in chondrogenic or adipogenic abilities between BMA-MSCs and BMAC-MSCs. The expression levels of selected angiogenic and immunomodulatory mediators were also similar between the two groups. Collectively, the vertical centrifugation system helped to enrich BM-MSCs effectively, while maintaining cell viability and functions. Thus, such a vertical centrifugation system for BM concentration can be valuable for various regenerative therapies

The El Niño event of 2015-16: climate anomalies and their impact on groundwater resources in East and Southern Africa

The impact of climate variability on groundwater storage has received limited attention despite widespread dependence on groundwater as a resource for drinking water, agriculture and industry. Here, we assess the climate anomalies that occurred over Southern Africa (SA) and East Africa, south of the equator (EASE), during the major El Niño event of 2015-16, and their associated impacts on groundwater storage, across scales, through analysis of in situ groundwater piezometry and GRACE satellite data. At the continental scale, the El Niño of 2015-16 was associated with a pronounced dipole of opposing rainfall anomalies over EASE and Southern Africa, north/south of ~120S, a characteristic pattern of ENSO. Over Southern Africa the most intense drought event in the historical record occurred, based on an analysis of the cross-scale areal intensity of surface water balance anomalies (as represented by the Standardised Precipitation-Evapotranspiration Index, SPEI), with an estimated return period of at least 200 years and a best estimate of 260 years. Climate risks are changing and we estimate that anthropogenic warming only (ignoring changes to other climate variables e.g. 43 precipitation) has approximately doubled the risk of such an extreme SPEI drought event. These surface water balance deficits suppressed groundwater recharge, leading to a substantial groundwater storage decline indicated by both GRACE satellite and piezometric data in the 46 Limpopo basin. Conversely, over EASE during the 2015-16 El Niño event, anomalously wet conditions were observed with an estimated return period of ~10 years, likely moderated by the absence of a strongly positive Indian Ocean Zonal Mode phase. The strong but not extreme rainy season increased groundwater storage as shown by satellite GRACE data and rising groundwater levels observed at a site in central Tanzania. We note substantial uncertainties in separating groundwater from total water storage in GRACE data and show that consistency between GRACE and piezometric estimates of groundwater storage is apparent when spatial averaging scales are comparable. These results have implications for sustainable and climate-resilient groundwater resource management, including the potential for adaptive strategies, such as managed aquifer recharge during episodic recharge events