Geometric relationships for homogenization in single-phase binary alloy systems

A semiempirical relationship is presented which describes the extent of interaction between constituents in single-phase binary alloy systems having planar, cylindrical, or spherical interfaces. This relationship makes possible a quick estimate of the extent of interaction without lengthy numerical calculations. It includes two parameters which are functions of mean concentration and interface geometry. Experimental data for the copper-nickel system are included to demonstrate the usefulness of this relationship

The Role of Kinetic Energy Flux in the Convective Urca Process

The previous analysis of the convective Urca neutrino loss process in degenerate, convective, quasi-static, carbon-burning cores by Barkat and Wheeler omitted specific consideration of the role of the kinetic energy flux. The arguments of Barkat and Wheeler that steady-state composition gradients exist are correct, but chemical equilibrium does not result in net cooling. Barkat and Wheeler included a "work" term that effectively removed energy from the total energy budget that could only have come from the kinetic energy, which must remain positive. Consideration of the kinetic energy in the thermodynamics of the convective Urca process shows that the convective Urca neutrinos reduce the rate of increase of entropy that would otherwise be associated with the input of nuclear energy and slow down the convective current, but, unlike the "thermal" Urca process do not reduce the entropy or temperature.Comment: 16 pages, AAS LaTex, in press, Astrophysical Journal, September 20, Vol 52

Observational manifestations of solar magneto-convection -- center-to-limb variation

We present the first center-to-limb G-band images synthesized from high resolution simulations of solar magneto-convection. Towards the limb the simulations show "hilly" granulation with dark bands on the far side, bright granulation walls and striated faculae, similar to observations. At disk center G-band bright points are flanked by dark lanes. The increased brightness in magnetic elements is due to their lower density compared with the surrounding intergranular medium. One thus sees deeper layers where the temperature is higher. At a given geometric height, the magnetic elements are cooler than the surrounding medium. In the G-band, the contrast is further increased by the destruction of CH in the low density magnetic elements. The optical depth unity surface is very corrugated. Bright granules have their continuum optical depth unity 80 km above the mean surface, the magnetic elements 200-300 km below. The horizontal temperature gradient is especially large next to flux concentrations. When viewed at an angle, the deep magnetic elements optical surface is hidden by the granules and the bright points are no longer visible, except where the "magnetic valleys" are aligned with the line of sight. Towards the limb, the low density in the strong magnetic elements causes unit line-of-sight optical depth to occur deeper in the granule walls behind than for rays not going through magnetic elements and variations in the field strength produce a striated appearance in the bright granule walls.Comment: To appear in ApJL. 6 pages 4 figure

HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes

HOXA10 is necessary for embryonic patterning of skeletal elements, but its function in bone formation beyond this early developmental stage is unknown. Here we show that HOXA10 contributes to osteogenic lineage determination through activation of Runx2 and directly regulates osteoblastic phenotypic genes. In response to bone morphogenic protein BMP2, Hoxa10 is rapidly induced and functions to activate the Runx2 transcription factor essential for bone formation. A functional element with the Hox core motif was characterized for the bone-related Runx2 P1 promoter. HOXA10 also activates other osteogenic genes, including the alkaline phosphatase, osteocalcin, and bone sialoprotein genes, and temporally associates with these target gene promoters during stages of osteoblast differentiation prior to the recruitment of RUNX2. Exogenous expression and small interfering RNA knockdown studies establish that HOXA10 mediates chromatin hyperacetylation and trimethyl histone K4 (H3K4) methylation of these genes, correlating to active transcription. HOXA10 therefore contributes to early expression of osteogenic genes through chromatin remodeling. Importantly, HOXA10 can induce osteoblast genes in Runx2 null cells, providing evidence for a direct role in mediating osteoblast differentiation independent of RUNX2. We propose that HOXA10 activates RUNX2 in mesenchymal cells, contributing to the onset of osteogenesis, and that HOXA10 subsequently supports bone formation by direct regulation of osteoblast phenotypic genes. <br/

Program on stimulating operational private sector use of Earth observation satellite information

Ideas for new businesses specializing in using remote sensing and computerized spatial data systems were developd. Each such business serves as an 'information middleman', buying raw satellite or aircraft imagery, processing these data, combining them in a computer system with customer-specific information, and marketing the resulting information products. Examples of the businesses the project designed are: (1) an agricultural facility site evaluation firm; (2) a mass media grocery price and supply analyst and forecaster; (3) a management service for privately held woodlots; (4) a brokerage for insulation and roofing contractors, based on infrared imagery; (5) an expanded real estate information service. In addition, more than twenty-five other commercially attractive ideas in agribusiness, forestry, mining, real estate, urban planning and redevelopment, and consumer information were created. The commercial feasibility of the five business was assessed. This assessment included market surveys, revenue projections, cost analyses, and profitability studies. The results show that there are large and enthusiastic markets willing to pay for the services these businesses offer, and that the businesses could operate profitably

Routine repeat head CT may not be necessary for patients with mild TBI.

Background:Routine repeat cranial CT (RHCT) is standard of care for CT-verified traumatic brain injury (TBI). Despite mixed evidence, those with mild TBI are subject to radiation and expense from serial CT scans. Thus, we investigated the necessity and utility of RHCT for patients with mild TBI. We hypothesized that repeat head CT in these patients would not alter patient care or outcomes. Methods:We retrospectively studied patients suffering from mild TBI (Glasgow Coma Scale (GCS) score 13-15) and treated at the R Adams Cowley Shock Trauma Center from November 2014 through January 2015. The primary outcome was the need for surgical intervention. Outcomes were compared using paired Student's t-test, and stratified by injury on initial CT, GCS change, demographics, and presenting vital signs (mean ± SD). Results:Eighty-five patients met inclusion criteria with an average initial GCS score=14.6±0.57. Our center sees about 2800 patients with TBI per year, or about 230 per month. This includes patients with concussions. This sample represents about 30% of patients with TBI seen during the study period. Ten patients required operation (four based on initial CT and others for worsening GCS, headaches, large unresolving injury). There was progression of injury on repeat CT scan in only two patients that required operation, and this accompanied clinical deterioration. The mean brain Abbreviated Injury Scale (AIS) score was 4.8±0.3 for surgical patients on initial CT scan compared with 3.4±0.6 (P&lt;0.001) for non-surgical patients. Initial CT subdural hematoma size was 1.1±0.6 cm for surgical patients compared with 0.49±0.3 cm (P=0.05) for non-surgical patients. There was no significant difference between intervention groups in terms of other intracranial injuries, demographics, vital signs, or change in GCS. Overall, 75 patients that did not require surgical intervention received RHCT. At $340 per CT,$51 000 was spent on unnecessary imaging ($367 000/year, extrapolated). Discussion:In an environment of increased scrutiny on healthcare expenditures, it is necessary to question dogma and eliminate unnecessary cost. Our data questions the use of routine repeat head CT scans in every patient with anatomic TBI and suggests that clinically stable patients with small injury can simply be followed clinically. Level of evidence:Level III

Solar Oscillations and Convection: II. Excitation of Radial Oscillations

Solar p-mode oscillations are excited by the work of stochastic, non-adiabatic, pressure fluctuations on the compressive modes. We evaluate the expression for the radial mode excitation rate derived by Nordlund and Stein (Paper I) using numerical simulations of near surface solar convection. We first apply this expression to the three radial modes of the simulation and obtain good agreement between the predicted excitation rate and the actual mode damping rates as determined from their energies and the widths of their resolved spectral profiles. We then apply this expression for the mode excitation rate to the solar modes and obtain excellent agreement with the low l damping rates determined from GOLF data. Excitation occurs close to the surface, mainly in the intergranular lanes and near the boundaries of granules (where turbulence and radiative cooling are large). The non-adiabatic pressure fluctuations near the surface are produced by small instantaneous local imbalances between the divergence of the radiative and convective fluxes near the solar surface. Below the surface, the non-adiabatic pressure fluctuations are produced primarily by turbulent pressure fluctuations (Reynolds stresses). The frequency dependence of the mode excitation is due to effects of the mode structure and the pressure fluctuation spectrum. Excitation is small at low frequencies due to mode properties -- the mode compression decreases and the mode mass increases at low frequency. Excitation is small at high frequencies due to the pressure fluctuation spectrum -- pressure fluctuations become small at high frequencies because they are due to convection which is a long time scale phenomena compared to the dominant p-mode periods.Comment: Accepted for publication in ApJ (scheduled for Dec 10, 2000 issue). 17 pages, 27 figures, some with reduced resolution -- high resolution versions available at http://www.astro.ku.dk/~aake/astro-ph/0008048

Effect of Intermolecular Interactions between CH Frequencies on the Infrared Spectra of N‐Paraffins and Polythene

A systematic study has been made of the infrared absorption band near 725 cm—1 which arises from the rocking vibration of methylene groups in n‐paraffins and in polyethylene. In unoriented crystals of n‐paraffins, this band exhibits two components of equal intensity below the transition point; above the transition temperature and in the liquid state only the higher frequency component is found. In solid cold‐drawn polyethylene the two components are of unequal intensity, the low frequency component being the stronger; in liquid polyethylene only the lower frequency component is found. Studies were made of polyethylene in various states of crystallinity and orientation, using both polarized and unpolarized radiation. The results obtained can be consistently interpreted, if the higher frequency component is attributed to crystallites in the polyethylene and the lower frequency component is assumed to be due partly to the crystalline and partly to the amorphous form of the polyethylene. It is concluded that the doubling of this frequency arises from some interaction between methylene groups which is peculiar to the crystalline state of long chain n‐paraffins below their transition points.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/69988/2/JCPSA6-22-12-1993-1.pd