The earth's trapped radiation belts

The near-earth charged particle environment is discussed in terms of spacecraft design criteria. Models are presented of the trapped radiation belts and based on in-situ data obtained from spacecraft

Performance analysis of flexible aircraft with active control

Small perturbation equations of motion of a flexible aircraft with an active control technology (ACT) system were developed to evaluate the stability and performance of the controlled aircraft. The total aircraft system was formulated in state vector format and the system of equations was completed with fully unsteady and low frequency aerodynamics for arbitrary, complex configurations based on a potential aerodynamic method. The ACT system equations were incorporated in the digital computer program FCAP (Flight Control Analysis Program) which can be used for the analysis of complete aircraft configurations, including control system, with either low frequency or fully unsteady aerodynamics. The application of classical performance analyses including frequency response, poles and zeros, mean square response, and time response in FCAP in state vector format was discussed

Structural interaction with control systems

A monograph which assesses the state of the art of space vehicle design and development is presented. The monograph presents criteria and recommended practices for determining the structural data and a mathematical structural model of the vehicle needed for accurate prediction of structure and control-system interaction; for design to minimize undesirable interactions between the structure and the control system; and for determining techniques to achieve the maximum desirable interactions and associated structural design benefits. All space vehicles are treated, including launch vehicles, spacecraft, and entry vehicles. Important structural characteristics which affect the structural model used for structural and control-system interaction analysis are given

Theoretical dynamic analysis of the landing loads on a vehicle with a tricycle landing gear

Theoretical dynamic analysis of landing loads on vehicle with tricycle landing gear compared with X-15 aircraft dat

Aerodynamic interference effects on tilting proprotor aircraft

The Green's function method was used to study tilting proprotor aircraft aerodynamics with particular application to the problem of the mutual interference of the wing-fuselage-tail-rotor wake configuration. While the formulation is valid for fully unsteady rotor aerodynamics, attention was directed to steady state aerodynamics, which was achieved by replacing the rotor with the actuator disk approximation. The use of an actuator disk analysis introduced a mathematical singularity into the formulation; this problem was studied and resolved. The pressure distribution, lift, and pitching moment were obtained for an XV-15 wing-fuselage-tail rotor configuration at various flight conditions. For the flight configurations explored, the effects of the rotor wake interference on the XV-15 tilt rotor aircraft yielded a reduction in the total lift and an increase in the nose-down pitching moment. This method provides an analytical capability that is simple to apply and can be used to investigate fuselage-tail rotor wake interference as well as to explore other rotor design problem areas

Comparison of blood sirolimus, tacrolimus and everolimus concentrations measured by LC-MS/MS, HPLC-UV and immunoassay methods

ObjectivesAn LC-MS/MS method was developed for simultaneous quantitation of tacrolimus, sirolimus and everolimus in whole blood, and compared to HPLC-UV and immunoassay methods.Design and methodsBlood (0.1mL) was analysed following solid-phase extraction and chromatographic resolution using a C18 column (45°C) and mobile phase of methanol/40mM ammonium acetate/glacial acetic acid (83/17/0.1) at 200μL/min, with positive electrospray ionisation and multiple reaction monitoring.ResultsIntra- and inter-day imprecision and inaccuracy were ≤12.2% over a 1.5-40μg/L calibration range. An external quality assurance programme confirmed acceptable inaccuracy and imprecision of the LC-MS/MS method, but highlighted problems with immunoassay quantitation, particularly for everolimus, showing a >30% bias in FPIA everolimus concentrations measured in pooled patient samples versus spiked drug-free whole blood.ConclusionsLC-MS/MS provides significant accuracy and precision advantages compared to HPLC and immunoassays. Discrepancies in everolimus concentrations measured by the Seradyn FPIA immunoassay require further investigation.Benedetta C. Sallustio, Benjamin D. Noll, Raymond G. Morri

Ground-Based Coronagraphy with High Order Adaptive Optics

We summarize the theory of coronagraphic optics, and identify a dimensionless fine-tuning parameter, F, which we use to describe the Lyot stop size in the natural units of the coronagraphic optical train and the observing wavelength. We then present simulations of coronagraphs matched to adaptive optics (AO) systems on the Calypso 1.2m, Palomar Hale 5m and Gemini 8m telescopes under various atmospheric conditions, and identify useful parameter ranges for AO coronagraphy on these telescopes. Our simulations employ a tapered, high-pass filter in spatial frequency space to mimic the action of adaptive wavefront correction. We test the validity of this representation of AO correction by comparing our simulations with recent K-band data from the 241-channel Palomar Hale AO system and its dedicated PHARO science camera in coronagraphic mode.Comment: To appear in ApJ, May 2001 (28 pages, 10 figs