Autotuning Algorithmic Choice for Input Sensitivity

Empirical autotuning is increasingly being used in many domains to achieve optimized performance in a variety of different execution environments. A daunting challenge faced by such autotuners is input sensitivity, where the best autotuned configuration may vary with different input sets. In this paper, we propose a two level solution that: first, clusters to find input sets that are similar in input feature space; then, uses an evolutionary autotuner to build an optimized program for each of these clusters; and, finally, builds an adaptive overhead aware classifier which assigns each input to a specific input optimized program. Our approach addresses the complex trade-off between using expensive features, to accurately characterize an input, and cheaper features, which can be computed with less overhead. Experimental results show that by adapting to different inputs one can obtain up to a 3x speedup over using a single configuration for all inputs

2-r-(4-Chloro­phen­yl)-6-c-phenyl-3,4,5,6-tetra­hydro-2H-thio­pyran-4-one 1-oxide

The thio­pyran unit of the title mol­ecule, C17H15ClO2S, is in chair form. A crystallographic mirror plane bis­ects the mol­ecule, passing through the O=S and the opposite C=O atoms of the central ring, with statistical disorder of the Cl atom. The geometry around the S atom is tetra­hedral and the carbonyl C is planar. The 4-chloro­phenyl group at the 2 position and the phenyl ring at the 6 position have equatorial orientations. Inter­molecular C—H⋯O and C—H⋯Cl hydrogen bonds are found in the crystal structure. In addition, there is a short O⋯C inter­molecular contact [2.970 (5) Å]

Mortality Not Correlated With Paclitaxel Exposure

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An anti-siglec-8 antibody depletes sputum eosinophils from asthmatic subjects and inhibits lung mast cells

Background Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is expressed on mast cells and eosinophils, but information about Siglec-8 expression and function in the lung is limited. A humanized antibody, AK002, targeting Siglec-8 is undergoing development for treatment of diseases associated with mast cell and eosinophil-driven inflammation. Objective To characterize Siglec-8 expression in the airway in asthma and determine whether antibodies that target Siglec-8 (S8mAbs) can decrease airway eosinophils in asthma or inhibit lung mast cell activation. Methods Gene expression profiling and flow cytometry were used to characterize Siglec-8 expression in sputum cells from stable asthma. An antibody-dependent cellular cytotoxicity (ADCC) assay was used to determine whether an S8mAb can decrease eosinophils in sputum from asthma patients ex vivo. A mast cell activation assay was used to determine whether an S8mAb can inhibit mast cell activation in human lung tissue ex vivo. Results Gene expression for Siglec-8 is increased in sputum cells in asthma and correlates with gene expression for eosinophils and mast cells. Gene expression for Siglec-8 is inversely and significantly correlated with measures of airflow obstruction in asthma patients. Siglec-8 is prominently expressed on the surface of eosinophils and mast cells in sputum. S8mAbs decrease eosinophils in sputum from patients with asthma and inhibit Fc epsilon R1-activated mast cells in lung tissues. Conclusions and Clinical Relevance Siglec-8 is highly expressed on eosinophils and mast cells in asthmatic sputum and targeting Siglec-8 with an antibody is a plausible strategy to decrease sputum eosinophils and inhibit lung mast cells in asthma

On arbitrages arising from honest times

In the context of a general continuous financial market model, we study whether the additional information associated with an honest time gives rise to arbitrage profits. By relying on the theory of progressive enlargement of filtrations, we explicitly show that no kind of arbitrage profit can ever be realised strictly before an honest time, while classical arbitrage opportunities can be realised exactly at an honest time as well as after an honest time. Moreover, stronger arbitrages of the first kind can only be obtained by trading as soon as an honest time occurs. We carefully study the behavior of local martingale deflators and consider no-arbitrage-type conditions weaker than NFLVR.Comment: 25 pages, revised versio