673 research outputs found
Available Coal Resources of the Booneville 7.5–Minute Quadrangle, Owsley County, Kentucky
The Booneville Quadrangle lies within the Southwestern Reserve District of the Eastern Kentucky Coal Field. Six coal beds in the quadrangle have been commercially developed, mainly by surface mining methods, and comprise the basis of this Coal Availability Study. These beds are, in descending stratigraphic order, Copland, Whitesburg, Amburgy, Upper Elkhorn No. 3, Jellico and Manchester. A computerized Geographic Information System (GRASS) was used to calculate estimates of original, mined-out and remaining resources, restrictions to mining and available resources
Finite strain Landau theory of high pressure phase transformations
The properties of materials near structural phase transitions are often
successfully described in the framework of Landau theory. While the focus is
usually on phase transitions, which are induced by temperature changes
approaching a critical temperature T-c, here we will discuss structural phase
transformations driven by high hydrostatic pressure, as they are of major
importance for understanding processes in the interior of the earth. Since at
very high pressures the deformations of a material are generally very large,
one needs to apply a fully nonlinear description taking physical as well as
geometrical nonlinearities (finite strains) into account. In particular it is
necessary to retune conventional Landau theory to describe such phase
transitions. In Troster et al (2002 Phys. Rev. Lett. 88 55503) we constructed a
Landau-type free energy based on an order parameter part, an order
parameter-(finite) strain coupling and a nonlinear elastic term. This model
provides an excellent and efficient framework for the systematic study of phase
transformations for a wide range of materials up to ultrahigh pressures
Irreducible Multiplets of Three-Quark Operators on the Lattice: Controlling Mixing under Renormalization
High luminosity accelerators have greatly increased the interest in
semi-exclusive and exclusive reactions involving nucleons. The relevant
theoretical information is contained in the nucleon wavefunction and can be
parametrized by moments of the nucleon distribution amplitudes, which in turn
are linked to matrix elements of three-quark operators. These can be calculated
from first principles in lattice QCD. However, on the lattice the problems of
operator mixing under renormalization are rather involved. In a systematic
approach we investigate this issue in depth. Using the spinorial symmetry group
of the hypercubic lattice we derive irreducibly transforming three-quark
operators, which allow us to control the mixing pattern.Comment: 13 page
A management algorithm for adult patients with both brain oxygen and intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC)
Electron-spin-resonance in the doped spin-Peierls compound Cu(1-x)Ni(x)GeO3
ESR-study of the Ni-doped spin-Peierls compound CuGeO3 has been performed in
the frequency range 9-75 GHz. At low temperatures the g-factor is smaller than
the value expected for Cu- and Ni-ions. This anomaly is explained by the
formation of magnetic clusters around the Ni-ions within a nonmagnetic
spin-Peierls matrix. The transition into the AFM-state detected earlier by
neutron scattering for doped samples was studied by means of ESR. For x=0.032 a
gap in the magnetic resonance spectrum is found below the Neel temperature and
the spectrum is well described by the theory of antiferromagnetic resonance
based on the molecular field approximation. For x=0.017 the spectrum below the
Neel point remained gapless. The gapless spectrum of the antiferromagnetic
state in weekly doped samples is attributed to the small value of the Neel
order parameter and to the magnetically disordered spin-Peierls background.Comment: 16 pages, LATEX, 12 figures, submitted to Journal of Physics :
Condensed Matte
Guidelines for the Management of Severe Traumatic Brain Injury: 2020 Update of the Decompressive Craniectomy Recommendations
© Congress of Neurological Surgeons 2020. When the fourth edition of the Brain Trauma Foundation\u27s Guidelines for the Management of Severe Traumatic Brain Injury were finalized in late 2016, it was known that the results of the RESCUEicp (Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension) randomized controlled trial of decompressive craniectomy would be public after the guidelines were released. The guideline authors decided to proceed with publication but to update the decompressive craniectomy recommendations later in the spirit of living guidelines, whereby topics are updated more frequently, and between new editions, when important new evidence is published. The update to the decompressive craniectomy chapter presented here integrates the findings of the RESCUEicp study as well as the recently published 12-mo outcome data from the DECRA (Decompressive Craniectomy in Patients With Severe Traumatic Brain Injury) trial. Incorporation of these publications into the body of evidence led to the generation of 3 new level-IIA recommendations; a fourth previously presented level-IIA recommendation remains valid and has been restated. To increase the utility of the recommendations, we added a new section entitled Incorporating the Evidence into Practice. This summary of expert opinion provides important context and addresses key issues for practitioners, which are intended to help the clinician utilize the available evidence and these recommendations. The full guideline can be found at: https://braintrauma.org/guidelines/guidelines-for-the-management-of-severe-tbi-4th-ed#/
A randomized double-blind placebo-controlled trial to investigate the effects of nasal calcitonin on bone microarchitecture measured by high-resolution peripheral quantitative computerized tomography in postmenopausal women — Study protocol
<p>Abstract</p> <p>Background</p> <p>Bone microarchitecture is a significant determinant of bone strength. So far, the assessment of bone microarchitecture has required bone biopsies, limiting its utilization in clinical practice to one single skeletal site. With the advance of high-resolution imaging techniques, non-invasive in vivo measurement of bone microarchitecture has recently become possible. This provides an opportunity to efficiently assess the effects of anti-osteoporotic therapies on bone microarchitecture. We therefore designed a protocol to investigate the effects of nasal salmon calcitonin, an inhibitor of osteoclast activity, on bone microarchitecture in postmenopausal women, comparing weight bearing and non-weight bearing skeletal sites.</p> <p>Methods</p> <p>One hundred postmenopausal women will be included in a randomized, placebo-controlled, double-blind trial comparing the effect of nasal salmon calcitonin (200 UI/day) to placebo over two years. Bone microarchitecture at the distal radius and distal tibia will be determined yearly by high-resolution peripheral quantitative computerized tomography (p-QCT) with a voxel size of 82 μm and an irradiation of less than 5 μSv. Serum markers of bone resorption and bone formation will be measured every 6 months. Safety and compliance will be assessed. Primary endpoint is the change in bone microarchitecture; secondary endpoint is the change in markers of bone turnover.</p> <p>Hypothesis</p> <p>The present study should provide new information on the mode of action of nasal calcitonin. We hypothezise that - compared to placebo - calcitonin impacts on microstructural parameters, with a possible difference between weight bearing and non-weight bearing bones.</p> <p>Trial Registration</p> <p>ClinicalTrials.gov NCT00372099</p
Magnetic Resonance of the Intrinsic Defects of the Spin-Peierls Magnet CuGeO3
ESR of the pure monocrystals of CuGeO3 is studied in the frequency range 9-75
GHz and in the temperature interval 1.2-25 K. The splitting of the ESR line
into several spectral components is observed below 5 K, in the temperature
range where the magnetic susceptibility is suppressed by the spin-Peierls
dimerization. The analysis of the magnetic resonance signals allows one to
separate the signals of the S=1/2- and S=1 defects of the spin-Peierls phase.
The value of g-factor of these signals is close to that of the Cu-ion. The
additional line of the magnetic resonance is characterized by an anomalous
value of the g-factor and by the threshold-like increase of the microwave
susceptibility when the microwave power is increasing. The ESR signals are
supposingly attributed to two types of the planar magnetic defects, arising at
the boundaries of the domains of the spin-Peierls state with the different
values of the phase of the dimerization.Comment: LATEX-text, 12 PS-figures, typos corrected, LATEX-style change
Protocol for implementation of family health history collection and decision support into primary care using a computerized family health history system
<p>Abstract</p> <p>Background</p> <p>The CDC's Family History Public Health Initiative encourages adoption and increase awareness of family health history. To meet these goals and develop a personalized medicine implementation science research agenda, the Genomedical Connection is using an implementation research (T3 research) framework to develop and integrate a self-administered computerized family history system with built-in decision support into 2 primary care clinics in North Carolina.</p> <p>Methods/Design</p> <p>The family health history system collects a three generation family history on 48 conditions and provides decision support (pedigree and tabular family history, provider recommendation report and patient summary report) for 4 pilot conditions: breast cancer, ovarian cancer, colon cancer, and thrombosis. All adult English-speaking, non-adopted, patients scheduled for well-visits are invited to complete the family health system prior to their appointment. Decision support documents are entered into the medical record and available to provider's prior to the appointment. In order to optimize integration, components were piloted by stakeholders prior to and during implementation. Primary outcomes are change in appropriate testing for hereditary thrombophilia and screening for breast cancer, colon cancer, and ovarian cancer one year after study enrollment. Secondary outcomes include implementation measures related to the benefits and burdens of the family health system and its impact on clinic workflow, patients' risk perception, and intention to change health related behaviors. Outcomes are assessed through chart review, patient surveys at baseline and follow-up, and provider surveys. Clinical validity of the decision support is calculated by comparing its recommendations to those made by a genetic counselor reviewing the same pedigree; and clinical utility is demonstrated through reclassification rates and changes in appropriate screening (the primary outcome).</p> <p>Discussion</p> <p>This study integrates a computerized family health history system within the context of a routine well-visit appointment to overcome many of the existing barriers to collection and use of family history information by primary care providers. Results of the implementation process, its acceptability to patients and providers, modifications necessary to optimize the system, and impact on clinical care can serve to guide future implementation projects for both family history and other tools of personalized medicine, such as health risk assessments.</p
Clinical-pathological study on β-APP, IL-1β, GFAP, NFL, Spectrin II, 8OHdG, TUNEL, miR-21, miR-16, miR-92 expressions to verify DAI-diagnosis, grade and prognosis
Traumatic brain injury (TBI) is one of the most important death and disability cause, involving substantial costs, also in economic terms, when considering the young age of the involved subject. Aim of this paper is to report a series of patients treated at our institutions, to verify neurological results at six months or survival; in fatal cases we searched for βAPP, GFAP, IL-1β, NFL, Spectrin II, TUNEL and miR-21, miR-16, and miR-92 expressions in brain samples, to verify DAI diagnosis and grade as strong predictor of survival and inflammatory response. Concentrations of 8OHdG as measurement of oxidative stress was performed. Immunoreaction of β-APP, IL-1β, GFAP, NFL, Spectrin II and 8OHdG were significantly increased in the TBI group with respect to control group subjects. Cell apoptosis, measured by TUNEL assay, were significantly higher in the study group than control cases. Results indicated that miR-21, miR-92 and miR-16 have a high predictive power in discriminating trauma brain cases from controls and could represent promising biomarkers as strong predictor of survival, and for the diagnosis of postmortem traumatic brain injury
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