Constraints and Reality Conditions in the Ashtekar Formulation of General Relativity

We show how to treat the constraints and reality conditions in the $SO(3)$-ADM (Ashtekar) formulation of general relativity, for the case of a vacuum spacetime with a cosmological constant. We clarify the difference between the reality conditions on the metric and on the triad. Assuming the triad reality condition, we find a new variable, allowing us to solve the gauge constraint equations and the reality conditions simultaneously.Comment: LaTeX file, 12 pages, no figures; to appear in Classical and Quantum Gravit

Decoherence induced by Smith-Purcell radiation

The interaction between charged particles and the vacuum fluctuations of the electromagnetic field induces decoherence, and therefore affects the contrast of fringes in an interference experiment. In this article we show that if a double slit experiment is performed near a conducting grating, the fringe visibility is reduced. We find that the reduction of contrast is proportional to the number of grooves in the conducting surface, and that for realistic values of the parameters it could be large enough to be observed. The effect can be understood in terms of the Smith-Purcell radiation produced by the surface currents induced in the conductor.Comment: 10 pages, 3 figures. Improved discussion on experimental perspectives. References added. Version to appear in Phys. Rev.

Cost-effectiveness modelling of telehealth for patients with raised cardiovascular disease risk: evidence from a cohort simulation conducted alongside the Healthlines randomised controlled trial

OBJECTIVES: To investigate the long-term cost-effectiveness (measured as the ratio of incremental NHS cost to incremental quality-adjusted life years) of a telehealth intervention for patients with raised cardiovascular disease (CVD) risk. DESIGN: A cohort simulation model developed as part of the economic evaluation conducted alongside the Healthlines randomised controlled trial. SETTING: Patients recruited through primary care, and intervention delivered via telehealth service. PARTICIPANTS: Participants with a 10-year CVD risk ≥20%, as measured by the QRISK2 algorithm, and with at least 1 modifiable risk factor, individually randomised from 42 general practices in England. INTERVENTION: A telehealth service delivered over a 12-month period. The intervention involved a series of responsive, theory-led encounters between patients and trained health information advisors who provided access to information resources and supported medication adherence and coordination of care. PRIMARY AND SECONDARY OUTCOME MEASURES: Cost-effectiveness measured by net monetary benefit over the simulated lifetime of trial participants from a UK National Health Service perspective. RESULTS: The probability that the intervention was cost-effective depended on the duration of the effect of the intervention. The intervention was cost-effective with high probability if effects persisted over the lifetime of intervention recipients. The probability of cost-effectiveness was lower for shorter durations of effect. CONCLUSIONS: The intervention was likely to be cost-effective under a lifetime perspective. TRIAL REGISTRATION NUMBER: ISRCTN27508731; Results

Development of a high temperature battery final report

Development of battery with lithium-magnesium alloy anode, molten cuprous chloride cathode, and zeolite separator cells and cupric oxide cathode and porous glass separator cell

Experimental Validation of Contact Dynamics for In-Hand Manipulation

This paper evaluates state-of-the-art contact models at predicting the motions and forces involved in simple in-hand robotic manipulations. In particular it focuses on three primitive actions --linear sliding, pivoting, and rolling-- that involve contacts between a gripper, a rigid object, and their environment. The evaluation is done through thousands of controlled experiments designed to capture the motion of object and gripper, and all contact forces and torques at 250Hz. We demonstrate that a contact modeling approach based on Coulomb's friction law and maximum energy principle is effective at reasoning about interaction to first order, but limited for making accurate predictions. We attribute the major limitations to 1) the non-uniqueness of force resolution inherent to grasps with multiple hard contacts of complex geometries, 2) unmodeled dynamics due to contact compliance, and 3) unmodeled geometries dueto manufacturing defects.Comment: International Symposium on Experimental Robotics, ISER 2016, Tokyo, Japa

Generally covariant theories: the Noether obstruction for realizing certain space-time diffeomorphisms in phase space

Relying on known results of the Noether theory of symmetries extended to constrained systems, it is shown that there exists an obstruction that prevents certain tangent-space diffeomorphisms to be projectable to phase-space, for generally covariant theories. This main result throws new light on the old fact that the algebra of gauge generators in the phase space of General Relativity, or other generally covariant theories, only closes as a soft algebra and not a a Lie algebra. The deep relationship between these two issues is clarified. In particular, we see that the second one may be understood as a side effect of the procedure to solve the first. It is explicitly shown how the adoption of specific metric-dependent diffeomorphisms, as a way to achieve projectability, causes the algebra of gauge generators (constraints) in phase space not to be a Lie algebra --with structure constants-- but a soft algebra --with structure {\it functions}.Comment: 22 pages, version to be published in Classical & Quantum Gravit

Quitting patient care and career break intentions among general practitioners in South West England: findings of a census survey of general practitioners

Objective: Given recent concerns regarding general practitioner (GP) workforce capacity, we aimed to describe GPs’ career intentions, especially those which might impact on GP workforce availability over the next 5 years. Design: Census survey, conducted between April and June 2016 using postal and online responses , of all GPs on the National Health Service performers list and eligible to practise in primary care. Two reminders were used as necessary. Setting: South West England (population 3.5  million), a region with low overall socioeconomic deprivation. Participants: Eligible GPs were 2248 out of 3370 (67 % response rate). Main outcome measures: Reported likelihood of permanently leaving or reducing hours spent in direct patient care or of taking a career break within the next 5 years and present morale weighted for non-response. Results: Responders included 217 7 GPs engaged in patient care. Of these, 863 (37% weighted, 95%  CI 35 % to 39 %) reported a high likelihood of quitting direct patient care within the next 5 years. Overall, 1535 (70% weighted, 95%  CI 68 % to 72 %) respondents reported a career intention that would negatively impact GP workforce capacity over the next 5 years, through permanently leaving or reducing hours spent in direct patient care, or through taking a career break. GP age was an important predictor of career intentions; sharp increases in the proportion of GPs intending to quit patient care were evident from 52 years. Only 305 (14% weighted, 95%  CI 13 % to 16 %) reported high morale, while 1195 ( 54 % weighted, 95%  CI 52 % to 56 %) reported low morale. Low morale was particularly common among GP partners. Current morale strongly predicted GPs’ career intentions; those with very low morale were particularly likely to report intentions to quit patient care or to take a career break. Conclusions: A substantial majority of GPs in South West England report low morale. Many are considering career intentions which, if implemented, would adversely impact GP workforce capacity within a short time period. Study registration: NIHR HS&DR - 14/196/02, UKCRN ID 20700

A Connection Approach to Numerical Relativity

We discuss a general formalism for numerically evolving initial data in general relativity in which the (complex) Ashtekar connection and the Newman-Penrose scalars are taken as the dynamical variables. In the generic case three gauge constraints and twelve reality conditions must be solved. The analysis is applied to a Petrov type \{1111\} planar spacetime where we find a spatially constant volume element to be an appropriate coordinate gauge choice.Comment: 17 pages, LaTe

Local and systemic in vivo responses to osseointegrative titanium nanotube surfaces

Orthopedic implants requiring osseointegration are often surface modified; however, implants may shed these coatings and generate wear debris leading to complications. Titanium nanotubes (TiNT), a new surface treatment, may promote osseointegration. In this study, in vitro (rat marrow-derived bone marrow cell attachment and morphology) and in vivo (rat model of intramedullary fixation) experiments characterized local and systemic responses of two TiNT surface morphologies, aligned and trabecular, via animal and remote organ weight, metal ion, hematologic, and nondecalcified histologic analyses. In vitro experiments showed total adherent cells on trabecular and aligned TiNT surfaces were greater than control at 30 min and 4 h, and cells were smaller in diameter and more eccentric. Control animals gained more weight, on average; however, no animals met the institutional trigger for weight loss. No hematologic parameters (complete blood count with differential) were significantly different for TiNT groups vs. control. Inductively coupled plasma mass spectrometry (ICP-MS) showed greater aluminum levels in the lungs of the trabecular TiNT group than in those of the controls. Histologic analysis demonstrated no inflammatory infiltrate, cytotoxic, or necrotic conditions in proximity of K-wires. There were significantly fewer eosinophils/basophils and neutrophils in the distal region of trabecular TiNT-implanted femora; and, in the midshaft of aligned TiNT-implanted femora, there were significantly fewer foreign body giant/multinucleated cells and neutrophils, indicating a decreased immune response in aligned TiNT-implanted femora compared to controls