Pеngaruh Kualitas Pеlayanan Tеrhadap Kеpuasan Konsumеn (Survеi Pada Jamaah Umrah Pt.armina Mabror Kota Blitar Tahun 2012-2016)

This Rеsеarch aims to еxplain significant Influеncе of Sеrvicе Quality which consist Rеliability, Rеsponsivеnеss, Assurancе, Еmpathy, Tangiblеs, simultanеously and parcially to thе Consumеr Satisfaction. Thеn, variabеl that has a dominant influеncе on thе Consumеr Satisfaction. 74 pеoplе rеspondеnt rеsеarch samplе on thе Jamaah umrah of PT. Armina Mabror who livе in Blitar City which dеparturе in 2012-2016 from 281 population. Basеd on thе rеsult, variabеls of Sеrvicе Quality had significant simultanеous influеncе on Consumеr Satisfaction aftеr countеd with F-tеst, whilе variabеls of Sеrvicе Quality had significant parcially influеncе on Consumеr Satisfaction aftеr countеd with t-tеst. And variablе Еmpathy (X4) is a dominant variablе which influеncе on Consumеr Statisfaction, bеcausе variablе Еmpathy had thе biggеst t-tеst valuе than othеr variablеs, thе valuе is 2,321. Kеywords : Sеrvicе Quality, Consumеr Satisfactio

Исследование методом сетевой фармакологии и молекулярного докинга для выявления потенциальной противораковой активности морских цитотоксинов — осциллатоксинов D, E, и F

Oscillatoxins (OTXs) are cytotoxins produced by some marine cyanobacteria. Their unique structures show a great potency as an anticancer agent. The limited availability of OTX derivatives in nature provides little information about their biological activity. Some of OTX activities have been tested in the in vitro or in vivo studies toward cancer cell lines, but their exact mechanism of action on the target is unclear. In this study, we used the network pharmacology analysis method to predict the target and mechanism of action of oscillatoxin D (OTX-D), 30 methyl oscillatoxin D (30-methyl-OTX-D), oscillatoxin E (OTX-E), and oscillatoxin F (OTX-F). There are 20 possible targets of the four compounds toward cancer, and the main targets of them are PIK3CA, CDK1, and MTOR. This was also followed by the molecular docking study to understand the interaction between the four compounds and their targets. Molecular docking showed that the four compounds interacted well with the key targets. In this study, four derivatives of OTXs and their three key targets for the anticancer action were revealed suggesting multiple signaling pathways, including PD-L1 expression and PD‑1 checkpoint pathway in cancer, proteoglycans in cancer, and pathways in cancer, establishing a theoretical framework for the further experimental study.Осциллатоксины (OTXs) —  это цитотоксины, продуцируемые некоторыми морскими цианобактериями. Их уникальные структуры показывают высокую эффективность в качестве противораковых средств. Ограниченная доступность производных OTXs в природе дает мало информации об их биологической активности. Было тестировано несколько активностей OTXs в исследованиях in vitro или in vivo в отношении линий раковых клеток, но их точный механизм действия на мишень не ясен. В данном исследовании мы использовали метод сетевой фармакологии для прогнозирования мишеней и механизмов действия осциллатоксина D (OTX-D), 30 метил-осциллатоксина D (30-метил-OTX-D), осциллатоксина E (OTX-E), и осциллатоксина F (OTX-F). Существуют 20 возможных мишеней четырех соединений против рака и их основными мишенями являются PIK3CA, CDK1 и MTOR. Затем было проведено исследование методом молекулярного докинга для понимания взаимодействия между 4 соединениями и их мишенями. Молекулярный докинг показал, что 4 соединения хорошо взаимодействовали с ключевыми мишенями. В данной работе было выявлено 4 производных OTXs и 3 ключевых мишени для противоракового действия, указывая на множественные сигнальные пути, включая путь экспрессии PD-L1 и контрольной точки PD-1 при раке, протеогликаны при раке и пути при раке, устанавливая теоретические рамки для дальнейшего экспериментального исследования

KEPEMIMPINAN MANAJERIAL KEPALA SEKOLAH DALAM IMPLEMENTASI MANAJEMEN BERBASIS SEKOLAH DI SMA NEGERI 1 KOTA TERNATE

Abstract - The purpose of this study was to determine the principal's managerial leadership in the implementation of school-based management. Descriptive qualitative research method with data collection through observation, interviews and documentation. Data analysis of data reduction research, data presentation and conclusions. Checking the validity of the data using triangulation of methods and sources. The results showed that the principal's managerial was effective and efficient in planning, organizing, implementing and supervising the implementation of school-based management in SMA Negeri 1 Ternate City.   Keyword: Managerial Leadership, Principal, School Based ManagementAbstrak -  Tujuan penelitian ini untuk mengetahui kepemimpinan manajerial kepala sekolah dalam implementasi manajemen berbasis sekolah. Metode penelitian kualitatif deskriptif dengan pengumpulan data melalui observasi, wawancara dan dokumentasi. Analisis data penelitian reduksi data, penyajian data dan simpulan. Pengecekan keabsahan data menggunakan triangulasi metode dan sumber. Hasil penelitian menunjukkan bahwa manajerial kepala sekolah efektif dan efisien pada perencanaan, pengorganisasian, pelaksanaan dan pengawasan dalam implementasi manajemen berbasis sekolah di SMA Negeri 1 Kota Ternate.   Keyword: Kepemimpinan Manajerial, Kepala Sekolah, Manajemen Berbasis Sekolah. &nbsp

Implementasi Kinerja Komite Sekolah dalam Manajemen Berbasis Sekolah di SMA Negeri 1 Kota Ternate

AbstractThe purpose of this study was to determine the performance of the committee as a deliberative body, as a supporting body, as a controlling body and as a liaison body in school-based management at SMA Negeri 1 Kota Ternate. Descriptive qualitative research method with data collection through observation, interviews and documentation. Data analysis research data reduction, data presentation and conclusions. The subjects of this study were school committees and school principals. The research results showed that: 1). The school committee as a deliberative body was quite good in terms of school planning, program planning (curriculum, PMB and Assessment), management of educational resources (HR, S/P, Budget); 2) The school committee as a supporting body is quite good in terms of managing resources, managing facilities and infrastructure and managing the budget; 3) The school committee acts as a controller in terms of controlling educational planning, monitoring school program planning and monitoring educational output and 4) The school committee as a liaison body was quite good in terms of planning, program implementation and management of educational resources.Keywords: Performance, School Committee, School Based Management

Aplikasi Olahan Limbah Ternak Terhadap Pertumbuhan Bayam Merah (Amaranthus tricolor L.)

This study aims to determine the effect of the application of manure and bokashi fertilizer and their interaction on the growth of Red Spinach (A. Tricolor L.). This research was conducted in Atapage, Wajo Regency. The research design used was a completely randomized design (CRD) with 4 replications and consisted of 4 treatments, namely manure; bokashi fertilizer; manure + bokashi fertilizer; and without treatment. The research data were analyzed using variance and for the different tests, the Least Significant Difference Test was used at the 5% level. The results of the study statistically showed that the treatment given was significantly different from the observation parameters of plant height and number of leaves, the highest average was found in the treatment with bokashi fertilizer and the lowest was in the treatment without manure + bokashi fertilizer, while the root crown ratio parameter showed no significant difference

Aplikasi Olahan Limbah Ternak Terhadap Pertumbuhan Bayam Merah (Amaranthus tricolor L.)

This study aims to determine the effect of the application of manure and bokashi fertilizer and their interaction on the growth of Red Spinach (A. Tricolor L.). This research was conducted in Atapage, Wajo Regency. The research design used was a completely randomized design (CRD) with 4 replications and consisted of 4 treatments, namely manure; bokashi fertilizer; manure + bokashi fertilizer; and without treatment. The research data were analyzed using variance and for the different tests, the Least Significant Difference Test was used at the 5% level. The results of the study statistically showed that the treatment given was significantly different from the observation parameters of plant height and number of leaves, the highest average was found in the treatment with bokashi fertilizer and the lowest was in the treatment without manure + bokashi fertilizer, while the root crown ratio parameter showed no significant difference

Manajemen Lalu Lintas di Universitas Brawijaya

Universitas Brawijaya berlokasi pada Jalan Veteran, Malang. Didirikan pada tahun 1963. Universitas Brawijaya memiliki mahasiswa dari berbagai strata mulai Program Sarajana hingga Program Doktor yang tersebar pada 13 fakultas. Seiring dengan berjalannya waktu perkembangan Universitas Brawijaya semakin pesat dari tahun ke tahun, hal ini menimbulkan peningkatan bangkitan dan tarikan pergerakan dari mahasiswa yang tersebar di Kota Malang menuju Universitas Brawijaya, hal ini menyebabkan berkurangnya lahan parkir dan menyebabkan banyak kendaraan yang parkir dipinggir jalan menyebabkan kapasitas jalan berkurang dan lalu lintas menjadi tidak lancar karena meningkatnya jumlah pengguna kendaraan . Selain itu terjadi antrian pada pintu-pintu akses masuk-keluar pada Universitas Brawijaya, baik untuk pintu akses utama yaitu akses yang menhubungkan antara Universitas Brawijaya dengan jalan-jalan kolektor di Kota Malang. Pengumpulan data dilakukan dengan metode survei langsung pada tiap pintu gerbang dengan menggunakan metode simple random sampling dan ruas utama yaitu ruas Veteran – Soekarno Hatta dan ruas Veteran - Mayjend Panjaitan. Survei dilakukan selama 12 jam dari pukul 06.00 sampai pukul 18.00. Dari hasil analsis didapat bahwa kinerja pintu gerbang eksisting sudah melebihi kapasitas pelayanan maksimum yang ditandai dengan hasil analisis yang bernilai minus sehingga disarankan pengaturan dan desain pintu gerbang yang baru. Sedangkan untuk ruas utama didapatkan LOS D yang memiliki DS sebesar 0,903 dan DS tertinggi memiliki LOS A yang memiliki DS sebesar 0,300. Untuk itu direkomendasikan untuk memindahkan ruang parkir yang ada pada sisi kiri dan kanan ruas utama sehingga didapatkan DS terbesar sebesar 0,630 dan DS terendah sebesar 0,220