Automated Design of Tissue Engineering Scaffolds by Advanced CAD

The design of scaffolds with an intricate and controlled internal structure represents a challenge for Tissue Engineering. Several scaffold manufacturing techniques allow the creation of complex and random architectures, but have little or no control over geometrical parameters such as pore size, shape and interconnectivity- things that are essential for tissue regeneration. The combined use of CAD software and layer manufacturing techniques allow a high degree of control over those parameters, resulting in reproducible geometrical architectures. However, the design of the complex and intricate network of channels that are required in conventional CAD, is extremely time consuming: manually setting thousands of different geometrical parameters may require several days in which to design the individual scaffold structures. This research proposes an automated design methodology in order to overcome those limitations. The combined use of Object Oriented Programming and advanced CAD software, allows the rapid generation of thousands of different geometrical elements. Each has a different set of parameters that can be changed by the software, either randomly or according to a given mathematical formula, so that they match the different distribution of geometrical elements such as pore size and pore interconnectivity. This work describes a methodology that has been used to design five cubic scaffolds with pore size ranging from about 200 to 800 µm, each with an increased complexity of the internal geometry.Mechanical Engineerin

Evaluation of the advance/anticipatory care planning (ACP) facilitators training programme

This report presents an overview of the findings of the three phases of the study and assesses the degree to which the Facilitator Training Programme and Resource Pack have prepared the cohort of facilitators with the knowledge, skills and tools to deliver training initiatives in ACP to address local and regional needs

The synthesis of some acylglycines and related oxazolones

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Spectral density measurements of gyro noise

Power spectral density (PSD) was used to analyze the outputs of several gyros in the frequency range from 0.01 to 200 Hz. Data were accumulated on eight inertial quality instruments. The results are described in terms of input angle noise (arcsec 2/Hz) and are presented on log-log plots of PSD. These data show that the standard deviation of measurement noise was 0.01 arcsec or less for some gyros in the passband from 1 Hz down 10 0.01 Hz and probably down to 0.001 Hz for at least one gyro. For the passband between 1 and 100 Hz, uncertainties in the 0.01 and 0.05 arcsec region were observed

Discrete Group Actions on Spacetimes: Causality Conditions and the Causal Boundary

Suppose a spacetime $M$ is a quotient of a spacetime $V$ by a discrete group of isometries. It is shown how causality conditions in the two spacetimes are related, and how can one learn about the future causal boundary on $M$ by studying structures in $V$. The relations between the two are particularly simple (the boundary of the quotient is the quotient of the boundary) if both $V$ and $M$ have spacelike future boundaries and if it is known that the quotient of the future completion of $V$ is past-distinguishing. (That last assumption is automatic in the case of $M$ being multi-warped.)Comment: 32 page

How a pilot looks at altitude

Commerical pilot eye scanning data previously collected were reanalyzed to evaluate how pilot used the drum pointer altimeter. The results of these tests showed that the pilots seldom used the drum window apparently because it was difficult to read as indicated by average drum window dwell times of .6 seconds. It is suggested that pilot scanning data be collected for other type of altimeters in order to find those with good scanning characteristics

Extreme 18O-enrichment in majorite constrains a crustal origin of transition zone diamonds

The fate of subducted oceanic lithosphere and its role in the planet-scale geochemical cycle is a key problem in solid Earth studies. Asthenospheric and transition zone minerals included in diamond have been interpreted as representing subducted oceanic crust based on inclusion REE patterns and strong 13C depletion of their host diamond (δ13C as low as -23 ‰). This view/explanation, however, has been challenged by alternative interpretations that variable carbon isotopic compositions either result from high temperature fractionation involving carbides, or reflect primordial, unhomogenised mantle reservoirs. Here, we present the first oxygen isotope analyses of inclusions in such ultradeep diamonds – majoritic garnets in diamond from Jagersfontein (South Africa). The oxygen isotope compositions provide unambiguous evidence for derivation of the inclusions from subducted crustal materials. The δ18OVSMOW values of the majorites range from +8.6 ‰ to +10.0 ‰, well outside that of ambient mantle (+5.5 ±0.4 ‰) and indicate that the protoliths were very heavily weathered at relatively low temperatures. When this information is combined with the broadly eclogitic composition of the majoritic garnets, a derivation from subducted sea-floor basalts is implied. Based on the association between the heavy oxygen and light carbon, the light carbon isotope composition cannot relate to deep mantle processes and is also ultimately derived from the crust