Capecitabine in the management of colorectal cancer

5-Fluorouracil has been a mainstay in the treatment of colorectal cancer for nearly five decades; however, the use of oral formulations of the medication has been gaining increasing traction since capecitabine was approved for use in adjuvant settings by the US Food and Drug Administration in 2005. The use of capecitabine has since spread to a number of off-label indications, including the treatment of advanced or metastatic colorectal cancer and the neoadjuvant treatment of rectal cancer. In light of increasing utilization, it is critical that clinicians have a firm understanding of the literature supporting capecitabine across various settings as well as the attributes of the drug, such as its dosing recommendations, side-effect profile, and use in the elderly. The purpose of this review is to synthesize the literature in a fashion that can be used to help guide decisions. In a setting of increasing focus on cost, the pharmacoeconomic literature is also briefly reviewed

Impact of Medium Anisotropy on Quarkonium Dissociation and Regeneration

Quarkonium production in ultra-relativistic collisions plays a crucial role in probing the existence of hot QCD matter. This study explores quarkonia states dissociation and regeneration in the hot QCD medium while considering momentum anisotropy. The net quarkonia decay width ($\Gamma_{D}$) arises from two essential processes: collisional damping and gluonic dissociation. The quarkonia regeneration includes the transition from octet to singlet states within the anisotropic medium. Our study utilizes a medium-modified potential that incorporates anisotropy via particle distribution functions. This modified potential gives rise to collisional damping for quarkonia due to the surrounding medium, as well as the transition of quarkonia from singlet to octet states due to interactions with gluons. Furthermore, we employ the detailed balance approach to investigate the regeneration of quarkonia within this medium. Our comprehensive analysis spans various temperature settings, transverse momentum values, and anisotropic strengths. Notably, we find that, in addition to medium temperatures and heavy quark transverse momentum, anisotropy significantly influences the dissociation and regeneration of various quarkonia states.Comment: 9 pages and 4 captioned figure

The Role of Higher Education Institutions in Promoting Innovativeness and Passion towards Entrepreneurship among Students – A Meta-Analytic Review

With the growing importance of entrepreneurship education, entrepreneurship programs established within higher education institutions are thriving hard to achieve entrepreneurship educational outcomes in recent years. Several studies reported the role of higher education institutions in promoting entrepreneurship education and enhancing students\u27 skill sets in various ways. To extend this knowledge, this paper aims to analyse the role of higher education institutions in promoting innovativeness and passion among students pursuing entrepreneurship education. A meta-analytic review is conducted by combining the results from empirical analysis of 24 related studies. The influence of higher education institutions on entrepreneurship educational outcomes and individual transformations is examined and their relationships are exposed. The results of the review show that various components of higher education institutions are positively related to individual transformations (rc=0.579) and entrepreneurship educational outcomes (rc=0.331). It is also found that the passion (rc = 0.31) and innovativeness (rc = 0.2771) are positively correlated with entrepreneurship educational outcome. Moreover, institutional environment has a greater impact on passion (rc = 0.531). Thus, the results indicate that higher education institutions play an important role in promoting passion and innovativeness among students

Assaying Locomotor, Learning, and Memory Deficits in Drosophila Models of Neurodegeneration

Advances in genetic methods have enabled the study of genes involved in human neurodegenerative diseases using Drosophila as a model system1. Most of these diseases, including Alzheimer's, Parkinson's and Huntington's disease are characterized by age-dependent deterioration in learning and memory functions and movement coordination2. Here we use behavioral assays, including the negative geotaxis assay3 and the aversive phototaxic suppression assay (APS assay)4,5, to show that some of the behavior characteristics associated with human neurodegeneration can be recapitulated in flies. In the negative geotaxis assay, the natural tendency of flies to move against gravity when agitated is utilized to study genes or conditions that may hinder locomotor capacities. In the APS assay, the learning and memory functions are tested in positively-phototactic flies trained to associate light with aversive bitter taste and hence avoid this otherwise natural tendency to move toward light. Testing these trained flies 6 hours post-training is used to assess memory functions. Using these assays, the contribution of any genetic or environmental factors toward developing neurodegeneration can be easily studied in flies

Variations in the physico-chemical properties of Dal Lake, Srinagar, Kashmir

Basic physical and chemical characteristics of the water in Dal lake Srinagar were determined. Surface water was sampled on monthly basis from June 2010 to April 2011. To determine the variations in physico-chemical parameters of Dal lake, a total of 21 physico-chemical parameters from six different site spread in four basins of lake was monitored. Our findings highlighted the deterioration of water quality in the lake due to anthropogenic activity in the lake and urbanization. The lake can be considered as eutrophic as evidenced by its shallow depth (1 to 4.5 m), low transparency (1 to 2.8 m), and higher concentrations of other nutrients such as phosphates, nitrates, sulphates and chloride. Pearson correlation coefficients were calculated to identify the strength of relation between the variables. The significant correlation was found among the temperature, depth, alkalinity, calcium, ammonia, nitrate and total phosphorus. Cluster analysis was additionally performed to obtain similarity between the sites.Key words: Physico-chemical characteristics, Dal lake, anthropogenic activity

First record of pygmy killer whale Feresa attenuata Gray, 1874 from India with a review of their occurrence in the World Oceans

The pygmy killer whale Feresa attenuata Gray, 1874 has been reported from Munambam fishing harbour, Kochi for the first time in India. Two specimens, one adult of 2.2 m total length and a calf of 1.5 m were recorded. The sighting/ stranding records from 115 data sets of pygmy killer whales around the world have been documented in the paper. The range of distribution of this species is discussed

A Survey Addressing on High Performance On-Chip VLSI Interconnect

With the rapid increase in transmission speeds of communication systems, the demand for very high-speed lowpower VLSI circuits is on the rise. Although the performance of CMOS technologies improves notably with scaling, conventional CMOS circuits cannot simultaneously satisfy the speed and power requirements of these applications. In this paper we survey the state of the art of on-chip interconnect techniques for improving performance, power and delay optimization and also comparative analysis of various techniques for high speed design have been discussed

Morphometric characteristics of spinner dolphin, Stenella longirostris (Gray,1828) from Bay of Bengal

Morphometric characteristics of the spinner dolphin Stenella longirostris were analysed based on samples (n=16) collected from two centres along the east coast of India (Bay of Bengal). The total length of the samples ranged from 84 to 170 cm. Of the 11 characteristics related to the anterior part of the body, the ratio of 10 characteristics to the total length is higher for calf male than that of adult male. There are also a few conspicuous differences between adult male and female. The Bay of Bengal form appears to differ from the other forms of world oceans, confirming that the morphometric characteristics of the spinner dolphin vary greatly geographically

N-[(2,4-Dimethyl­phen­yl)carbamothio­yl]-2-methyl­benzamide

The title compound, C17H18N2OS, adopts a trans–cis geometry of the thio­urea group which is stabilized by intra­molecular hydrogen bonds between the O atom of the carbonyl group and the H atom of the thio­amide group. A C—H⋯S intramolecular hydrogen bond is also present. In the crystal structure, mol­ecules are linked by inter­molecular N—H⋯S hydrogen bonds to form centrosymmetric dimers

Assessment of Genetic Divergence in Long Day Onion (Allium cepa L.) through Principal Component and Single Linkage Cluster Analysis

To assess the nature and magnitude of genetic diversity in long day onion germplasm by using the principal component analysis and single linkage cluster analysis an experiment was carried out with 34 onion genotypes. High coefficient of variation with wide range in traits indicated an appreciable variability in germplasm. Genotypes were classified into seven principal components having Eigen value > 1, cumulatively accounted for 83.87% of total variability. Principal Component - I contributed for 24.73% of total variation for followed by principal component-II (15.27%). PC-I had high positive loading for bulb weight (0.401), marketable yield (0.338), total bulb yield (0.401) and PC-II had high positive loading for plant height (0.412), PC-III for high T.S.S. (0.276) PC -IV for A grade bulbs (0.436), PC-V for polar diameter of bulbs (0.514), PC-IV negatively loaded with purple blotch (-0.461) and PC-VII for narrow neck thickness (-0 .515). Plotting PC-I aganist PC-II differenciated CITH-O-13, CITH-O-4, CITH-O-22, CITH-O-19, CITH-O-9, CITH-O-6 and CITH-O2 as most divergent genotype.On the basis of single linkage cluster means cluster-I was most importent for average bulb weight, minimum bolters, high marketble bulb percentage high marketable and total bulb yield whereas cluster -II was important for maximum nuber of leaves/plant and minimum neck thicknes. Highest inter-cluster distance was observed between cluter II and Cluster-I(873.5% ).Most divergent genotypes with high inter cluter distance could be the most appropriate parents for crop impovement in onion