Laboratory tests in patients treated with isotretinoin: occurrence of liver and muscle abnormalities and failure of AST and ALT to predict liver abnormality.

Current laboratory monitoring may not be optimal. A retrospective chart review was performed on thelaboratory results of 246 patients who were treated with isotretinoin for acne over a 9-year period. Tests obtained were CBC, lipid panel, AST, ALT, CK, GGT,and C-reactive protein. Thirty-five patients had an elevated AST and 35 of these had an elevated CK; 32 had an elevated ALT and 11 of these had an elevated CK. Thirteen patients had an elevated GGT; in 5 this was the only abnormality, whereas 8 had a GGT elevation accompanied by an elevated AST or ALT. Two had an elevated GGT and an elevated CK with normal AST and ALT. Fifty-two patients had a single episode of elevated CK, of which 22 were female. However, 57 had multiple CK elevations and only one was female. Thirty-five patients had CK elevationsnormal; 38 had levels between 2 and 3 times normal, 18 had levels between 3 and 4 times normal, and 18 had levels greater than 4 times normal. We suggest that ALT and AST are not useful for monitoring isotretinoin therapy and that GGT and CK may be of greater value in managing patients

Isothermal heat flux sensing unit Final report, Jun. 21, 1967 - Jan. 2, 1968

Thermal analysis, theory of operation, and operating instructions for isothermal heat flux sensing uni

Forward-scatter radiant mapping

Forward-scatter systems have been much neglected for the study of meteors and meteor streams. A great deal of this neglect stems from the complicated geometry which has made the interpretation of results difficult in the past. This no longer presents a problem because of the computer power now available. There are practical advantages in using forward-scatter in that low-power transmitters are much easier to handle than the high-power ones used in pulsed back-scatter radars. The data reduction of the CW signals is also significantly simpler. Because the forward-scatter reflection geometry increases the duration of the echoes relative to the back-scatter case, the problem of the underdense ceiling is partially alleviated. We have built a 'short hop' forward-scatter system between Ottawa and London (Ont) for which the transmitter and receiver are separated by about 500 km. With it, we are able to measure unambiguously the directions of arrival of the echoes using a 5-antenna interferometer. Morton and Jones (1982, MN, 198, 737) have shown how the echo direction distribution can be deconvolved to yield the meteor radiant distribution for back-scatter data. We have extended the technique to the forward-scatter case and present some preliminary meteor radiant distribution maps

Research into fundamental phenomena associated with spacecraft electrochemical devices - calorimetry of nickel-cadmium cells Progress report, 1 Oct. 1966 - 31 Dec. 1966

Cycling, charge efficiency, and transducer studies with nickel-cadmium cell for spacecraft power supply system

Audio/Grid Feedback: finding the right blend

A blended approach to assessment using voice recording to address the student personally alongside the application of traditional grid-based criteria, achieving a qualitative and holistic evaluation whilst preserving the transparency of a clear rationale for grading