21 research outputs found
Mesothelin versus Ca125 in Screening the Ovarian Malignancy
Objective: To determine the sensitivity and specificity of mesothelin
compared with Ca-125 as a tumor marker in predicting ovarian malignancy.
Method: The cross sectional study design with diagnostic tests was
conducted in 30 samples of patients undergoing elective laparotomy
due to ovarian tumor. We compared the sensitivity and specificity
between mesothelin and Ca-125, then the data were analyzed using
SPSS software version 22.0.
Result: According to the ROC curve analysis, optimal sensitivity and
specificity value of mesothelin was 63.2% and 54.5% at a cut-off
point of 0.45 pg/ml; or 42.1% and 72.7% at a cut-off point of 0.55
pg/ml. While the value of both optimal sensitivity and specificity of
Ca-125 was 73.7% and 63.6% at a cut-off point of 46.63 U/ml.
Conclusion: Mesothelin and Ca-125 are not different significantly
for the AUC value of 50%. Due to higher sensitivity and specificity of
Ca-125 than mesothelin, Ca-125 is still used as tumor marker for
screening the ovarian malignancy.
[Indones J Obstet Gynecol 2016; 4-2: 107-110]
Keywords: Ca-125, mesothelin, ovarian malignanc