The role of traction in membrane curvature generation.

Curvature of biological membranes can be generated by a variety of molecular mechanisms including protein scaffolding, compositional heterogeneity, and cytoskeletal forces. These mechanisms have the net effect of generating tractions (force per unit length) on the bilayer that are translated into distinct shapes of the membrane. Here, we demonstrate how the local shape of the membrane can be used to infer the traction acting locally on the membrane. We show that buds and tubes, two common membrane deformations studied in trafficking processes, have different traction distributions along the membrane and that these tractions are specific to the molecular mechanism used to generate these shapes. Furthermore, we show that the magnitude of an axial force applied to the membrane as well as that of an effective line tension can be calculated from these tractions. Finally, we consider the sensitivity of these quantities with respect to uncertainties in material properties and follow with a discussion on sources of uncertainty in membrane shape

Observations on the fecundity of the cyprinidRasbora daniconius (Hamilton)

The present paper reports the fecundity(F) ofRasbora daniconius in relation to the total body length (L), total body weight (W) and gonad weight (G) of the fish. Catch data indicated a predominance of females during the months of July–August which is the breeding season of this species. The collected fish in the length range of 7·7–11·7 cm bore a linear relationship with their weights. The fecundity of the fish ranged from 580 to 11040 eggs fish−1. Fecundity exhibited a linear relationship withL, G andW. By subjecting the data to multiple regression analyses, a new and convenient method of best predictions ofF inR. daniconius in relation toL alone has been developed

Entanglement via Barut-Girardello coherent state for suq(1,1)su_{q}(1, 1) quantum algebra: bipartite composite system

Using noncocommutative coproduct properties of the quantum algebras, we introduce and obtain, in a bipartite composite system, the Barut-Girardello coherent state for the q-deformed $su_{q}(1,1)$ algebra. The quantum coproduct structure ensures this normalizable coherent state to be entangled. The entanglement disappears in the classical $q \to 1$ limit, giving rise to a factorizable state.Comment: 12 page

Joint modeling with time-dependent treatment and heteroskedasticity: Bayesian analysis with application to the Framingham Heart Study

Medical studies for chronic disease are often interested in the relation between longitudinal risk factor profiles and individuals' later life disease outcomes. These profiles may typically be subject to intermediate structural changes due to treatment or environmental influences. Analysis of such studies may be handled by the joint model framework. However, current joint modeling does not consider structural changes in the residual variability of the risk profile nor consider the influence of subject-specific residual variability on the time-to-event outcome. In the present paper, we extend the joint model framework to address these two heterogeneous intra-individual variabilities. A Bayesian approach is used to estimate the unknown parameters and simulation studies are conducted to investigate the performance of the method. The proposed joint model is applied to the Framingham Heart Study to investigate the influence of anti-hypertensive medication on the systolic blood pressure variability together with its effect on the risk of developing cardiovascular disease. We show that anti-hypertensive medication is associated with elevated systolic blood pressure variability and increased variability elevates risk of developing cardiovascular disease.Comment: 34 pages, 4 figure

MPPT oscillations minimization in PV system by controlling non-linear dynamics in SEPIC DC-DC converter

Solar PV power generation has achieved rapid growth in developing countries which has many merits such as absence of noise, longer life, no pollution, less time for installation, and ease of grid interface. A maximum power point tracking circuit (MPPT) consists of DC-DC power electronics converters that are used to improve the energy attainment from solar PV array. This paper presents a detailed analysis to control of chaos, a non-linear dynamic in SEPIC DC-DC converter interfaced solar PV system, to minimize the oscillations near to MPP. In SEPIC DC-DC converter, the input inductor current is continuous and capable of sweeping the whole I-V curve of a PV module from open circuit voltage (Voc) to short circuit current (Isc) operating points. To trace the true maximum power point and to nullify the oscillations near to MPP, the yield output voltage needs to ensure period-1 operation

Delta isobar masses, large N_c relations, and the quark model

Motivated by recent remarks on the Delta+ mass and comparisons between the quark model and relations based on large-N_c with perturbative flavor breaking, two sets of Delta masses consistent with these constraints are constructed. These two sets, based either on an experimentally determined mass splitting or a quark model of isospin symmetry breaking, are shown to be inconsistent. The model dependence of this inconsistency is examined, and suggestions for improved experiments are made. An explicit quark model calculation and mass relations based on the large-N_c limit with perturbative flavor breaking are compared. The expected level of accuracy of such relations is realized in the quark model, except for mass relations spanning more than one SU(6) representation. It is shown that the Delta0 and Delta++ pole masses and Delta0 - Delta+ = (Delta- - Delta++)/3 about 1.5 MeV are more consistent with model expectations than the analogous Breit-Wigner masses and their splittings.Comment: 10 pages, including 1 eps figure, revte

Upanaha Sveda and its modification - A Critical Review

A fired building is best saved by pouring water , in the same way tropical problems are successfully managed by tropical treatment rather than systemic treatment. Upanaha is an ideal tropical treatment. Pradeha, Sankara/Panda Sveda, Bandhana are three varieties of Upanaha. It helps in reducing Vata Dosha, Sheeta (coldness), Shoola (pain), Sthambha (stiffness), Gouravatha (heaviness). It induces sweating and brings Doshavilayana. Sveda helps in Gatravinamana (increase the flexibility of body). Upanaha an Ayurvedic tropical treatment needs to evolve or adapt according to time so that it is easy to practice without changing its efficacy. Here an effort made to bring some modification in Upanaha

Erythrocyte Long-Chain Omega-3 Fatty Acid Levels are Inversely Associated with Mortality and with Incident Cardiovascular Disease: The Framingham Heart Study

Background: The extent to which omega-3 fatty acid status is related to risk for death from any cause and for incident cardiovascular disease (CVD) remains controversial. Objective: To examine these associations in the Framingham Heart Study. Design: Prospective and observational. Setting: Framingham Heart Study Offspring cohort. Measurements: The exposure marker was red blood cell levels of eicosapentaenoic and docosahexaenoic acids (the Omega-3 Index) measured at baseline. Outcomes included mortality (total, CVD, cancer, and other) and total CVD events in participants free of CVD at baseline. Follow-up was for a median of 7.3 years. Cox proportional hazards models were adjusted for 18 variables (demographic, clinical status, therapeutic, and CVD risk factors). Results: Among the 2500 participants (mean age 66 years, 54% women), there were 350 deaths (58 from CVD, 146 from cancer, 128 from other known causes, and 18 from unknown causes). There were 245 CVD events. In multivariable-adjusted analyses, a higher Omega-3 Index was associated with significantly lower risks (P-values for trends across quintiles) for total mortality (P = .02), for non-CVD and non-cancer mortality (P = .009), and for total CVD events (P = .008). Those in the highest (\u3e6.8%) compared to those in the lowest Omega-3 Index quintiles (\u3c4.2%) had a 34% lower risk for death from any cause and 39% lower risk for incident CVD. These associations were generally stronger for docosahexaenoic acid than for eicosapentaenoic acid. When total cholesterol was compared with the Omega-3 Index in the same models, the latter was significantly related with these outcomes, but the former was not. Limitations: Relatively short follow-up time and one-time exposure assessment. Conclusions: A higher Omega-3 Index was associated with reduced risk of both CVD and all-cause mortality