SPOTS: The Search for Planets Orbiting Two Stars. III. Complete Sample and Statistical Analysis

Binary stars constitute a large percentage of the stellar population, yet relatively little is known about the planetary systems orbiting them. Most constraints on circumbinary planets (CBPs) so far come from transit observations with the Kepler telescope, which is sensitive to close-in exoplanets but does not constrain planets on wider orbits. However, with continuous developments in high-contrast imaging techniques, this population can now be addressed through direct imaging. We present the full survey results of the Search for Planets Orbiting Two Stars (SPOTS) survey, which is the first direct imaging survey targeting CBPs. The SPOTS observational program comprises 62 tight binaries that are young and nearby, and thus suitable for direct imaging studies, with VLT/NaCo and VLT/SPHERE. Results from SPOTS include the resolved circumbinary disk around AK Sco, the discovery of a low-mass stellar companion in a triple packed system, the relative astrometry of up to 9 resolved binaries, and possible indications of non-background planetary-mass candidates around HIP 77911. We did not find any CBP within 300 AU, which implies a frequency upper limit on CBPs (1--15 $M_{\rm Jup}$) of 6--10 % between 30-300 AU. Coupling these observations with an archival dataset for a total of 163 stellar pairs, we find a best-fit CBP frequency of 1.9 % (2--15 $M_{\rm Jup}$) between 1--300 AU with a 10.5 % upper limit at a 95 % confidence level. This result is consistent with the distribution of companions around single stars.Comment: 27 pages, 13 Figures, 7 Tables. Accepted for publication in A&

Orbital characterization of GJ1108A system, and comparison of dynamical mass with model-derived mass for resolved binaries

We report an orbital characterization of GJ1108Aab that is a low-mass binary system in pre-main-sequence phase. Via the combination of astrometry using adaptive optics and radial velocity measurements, an eccentric orbital solution of $e$=0.63 is obtained, which might be induced by the Kozai-Lidov mechanism with a widely separated GJ1108B system. Combined with several observed properties, we confirm the system is indeed young. Columba is the most probable moving group, to which the GJ1108A system belongs, although its membership to the group has not been established. If the age of Columba is assumed for GJ1108A, the dynamical masses of both GJ1108Aa and GJ1108Ab ($M_{\rm dynamical,GJ1108Aa}=0.72\pm0.04 M_{\odot}$ and $M_{\rm dynamical,GJ1108Ab}=0.30\pm0.03 M_{\odot}$) are more massive than what an evolutionary model predicts based on the age and luminosities. We consider the discrepancy in mass comparison can attribute to an age uncertainty; the system is likely older than stars in Columba, and effects that are not implemented in classical models such as accretion history and magnetic activity are not preferred to explain the mass discrepancy. We also discuss the performance of the evolutionary model by compiling similar low-mass objects in evolutionary state based on the literature. Consequently, it is suggested that the current model on average reproduces the mass of resolved low-mass binaries without any significant offsets.Comment: Accepted in Ap

A Chromaticity Analysis and PSF Subtraction Techniques for SCExAO/CHARIS Data

We present an analysis of instrument performance using new observations taken with the Coronagraphic High Angular Resolution Imaging Spectrograph (CHARIS) instrument and the Subaru Coronagraphic Extreme Adaptive Optics (SCExAO) system. In a correlation analysis of our data sets (which use the broadband mode covering the J band through the K band in a single spectrum), we find that chromaticity in the SCExAO/CHARIS system is generally worse than temporal stability. We also develop a point-spread function (PSF) subtraction pipeline optimized for the CHARIS broadband mode, including a forward modeling-based exoplanet algorithmic throughput correction scheme. We then present contrast curves using this newly developed pipeline. An analogous subtraction of the same data sets using only the H-band slices yields the same final contrasts as the full JHK sequences; this result is consistent with our chromaticity analysis, illustrating that PSF subtraction using spectral differential imaging (SDI) in this broadband mode is generally not more effective than SDI in the individual J, H, or K bands. In the future, the data processing framework and analysis developed in this paper will be important to consider for additional SCExAO/CHARIS broadband observations and other ExAO instruments which plan to implement a similar integral field spectrograph broadband mode.Natural Sciences and Engineering Council of Canada through the Postgraduate Scholarships-Doctoral discovery grant; Technologies for Exo-Planetary Science Collaborative Research and Training Experience programs; JSPS [23340051, 26220704, 23103002]; Astrobiology Center of the National Institutes of Natural Sciences, Japan; Mt. Cuba Foundation; directors contingency fund at Subaru Telescope; MEXT of the Japanese government [23103002]This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Subaru/HiCIAO HKsHK_{\rm s} imaging of LkHα\alpha 330 - multi-band detection of the gap and spiral-like structures

We present $H$- and $K_{\rm s}$-bands observations of the LkH$\alpha$ 330 disk with a multi-band detection of the large gap and spiral-like structures. The morphology of the outer disk ($r\sim$0\farcs3) at PA=0--45$^\circ$ and PA=180--290$^\circ$ are likely density wave-induced spirals and comparison between our observational results and simulations suggests a planet formation. We have also investigated the azimuthal profiles at the ring and the outer-disk regions as well as radial profiles in the directions of the spiral-like structures and semi-major axis. Azimuthal analysis shows a large variety in wavelength and implies that the disk has non-axisymmetric dust distributions. The radial profiles in the major-axis direction (PA=$271^\circ$) suggest that the outer region (r\geq0\farcs25) may be influenced by shadows of the inner region of the disk. The spiral-like directions (PA=10$^\circ$ and 230$^\circ$) show different radial profiles, which suggests that the surfaces of the spiral-like structures are highly flared and/or have different dust properties. Finally, a color-map of the disk shows a lack of an outer eastern region in the $H$-band disk, which may hint the presence of an inner object that casts a directional shadow onto the disk.Comment: 12pages, 16 figures, 2 tables, accepted for publication in A

TIG3 Tumor Suppressor-Dependent Organelle Redistribution and Apoptosis in Skin Cancer Cells

TIG3 is a tumor suppressor protein that limits keratinocyte survival during normal differentiation. It is also important in cancer, as TIG3 level is reduced in tumors and in skin cancer cell lines, suggesting that loss of expression may be required for cancer cell survival. An important goal is identifying how TIG3 limits cell survival. In the present study we show that TIG3 expression in epidermal squamous cell carcinoma SCC-13 cells reduces cell proliferation and promotes morphological and biochemical apoptosis. To identify the mechanism that drives these changes, we demonstrate that TIG3 localizes near the centrosome and that pericentrosomal accumulation of TIG3 alters microtubule and microfilament organization and organelle distribution. Organelle accumulation at the centrosome is a hallmark of apoptosis and we demonstrate that TIG3 promotes pericentrosomal organelle accumulation. These changes are associated with reduced cyclin D1, cyclin E and cyclin A, and increased p21 level. In addition, Bax level is increased and Bcl-XL level is reduced, and cleavage of procaspase 3, procaspase 9 and PARP is enhanced. We propose that pericentrosomal localization of TIG3 is a key event that results in microtubule and microfilament redistribution and pericentrosomal organelle clustering and that leads to cancer cell apoptosis

Discovery of An au-scale Excess in Millimeter Emission from the Protoplanetary Disk around TW Hya

We report the detection of an excess in dust continuum emission at 233 GHz (1.3 mm in wavelength) in the protoplanetary disk (PPD) around TW Hya revealed through high-sensitivity observations at ~3 au resolution with the Atacama Large Millimeter/submillimeter Array. The sensitivity of the 233 GHz image has been improved by a factor of 3 with regard to that of our previous cycle 3 observations. The overall structure is mostly axisymmetric, and there are apparent gaps at 25 and 41 au as previously reported. The most remarkable new finding is a few astronomical-unit-scale excess emission in the southwest part of the PPD. The excess emission is located at 52 au from the disk center and is 1.5 times brighter than the surrounding PPD at a significance of 12σ. We performed a visibility fitting to the extracted emission after subtracting the axisymmetric PPD emission and found that the inferred size and the total flux density of the excess emission are 4.4 × 1.0 au and 250 μJy, respectively. The dust mass of the excess emission corresponds to 0.03 M ⊕ if a dust temperature of 18 K is assumed. Because the excess emission can also be marginally identified in the Band 7 image at almost the same position, the feature is unlikely to be a background source. The excess emission can be explained by a dust clump accumulated in a small elongated vortex or a massive circumplanetary disk around a Neptune-mass-forming planet

Effect of Kohl-Chikni Dawa – a compound ophthalmic formulation of Unani medicine on naphthalene-induced cataracts in rats

BACKGROUND: Cataracts are the leading cause of blindness worldwide, accounting for 13-27% of cases. Kohl-Chikni Dawa (KCD) is reputed for its beneficial effects in the treatment of premature cataracts. However, its efficacy is yet to be tested. To investigate the rationality of the therapeutic use of Kohl-Chikni Dawa (KCD) in Unani medicine. METHODS: The effect of Kohl-Chikni Dawa eye drops on naphthalene-induced cataracts in rats was investigated by slit-lamp biomicroscopic analysis. The normal group of experimental animals was administered with mineral oil (orally), while other groups were given naphthalene (orally) along with local application of KCD eye drops (once and twice daily), placebo and distilled water (twice daily). Initial morphological changes of the lenses were observed twice a week for two weeks, and thereafter once a week for four weeks. RESULTS: Local application of KCD (twice daily) caused significant reduction in the lens opacification after 2 to 4 weeks of naphthalene administration. CONCLUSION: KCD eye drops may have the potential to delay progression of naphthalene-induced cataracts in rats