500 research outputs found

    Excitation Enhancement of a Quantum Dot Coupled to a Plasmonic Antenna

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    Plasmonic antennas are key elements to control the luminescence of quantum emitters. However, the antenna's influence is often hidden by quenching losses. Here, the luminescence of a quantum dot coupled to a gold dimer antenna is investigated. Detailed analysis of the multiply excited states quantifies the antenna's influence on the excitation intensity and the luminescence quantum yield separately

    Intermolecular N-H...O=C hydrogen bonding in the crystal structure of 6-amino-1,3-dimethyluracil

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    The 6-amino- 1,3-dimethyluracil molecule [6-amino- 1,3- dimethyl-2,4(1H,3H)-pyrimidinedione], C6H9N302 (I), lies on a crystallographic mirror plane and participates in an extensive two-dimensional hydrogen-bonding network in the solid state. Each molecule is involved in N-- H...O=C hydrogen bonding involving the amino and carbonyl gr. oups, with O...N separations of 2.894 (3) and 2.904 (3) A

    Non-minimally coupled scalar field cosmology on the phase plane

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    In this publication we investigate dynamics of a flat FRW cosmological model with a non-minimally coupled scalar field with the coupling term ξRψ2\xi R \psi^{2} in the scalar field action. The quadratic potential function V(ψ)ψ2V(\psi)\propto \psi^{2} is assumed. All the evolutional paths are visualized and classified in the phase plane, at which the parameter of non-minimal coupling ξ\xi plays the role of a control parameter. The fragility of global dynamics with respect to changes of the coupling constant is studied in details. We find that the future big rip singularity appearing in the phantom scalar field cosmological models can be avoided due to non-minimal coupling constant effects. We have shown the existence of a finite scale factor singular point (future or past) where the Hubble function as well as its first cosmological time derivative diverges.Comment: revtex4, 20 pages, 12 figs; (v2) title changed, analysis of critical points at infinity added, accepted to JCA

    Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin

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    Pharmacological attenuation of mTOR presents a promising route for delay of age-related disease. Here we show that treatment of Drosophila with the mTOR inhibitor rapamycin extends lifespan in females, but not in males. Female-specific, age-related gut pathology is markedly slowed by rapamycin treatment, mediated by increased autophagy. Treatment increases enterocyte autophagy in females, via the H3/H4 histone-Bchs axis, whereas males show high basal levels of enterocyte autophagy that are not increased by rapamycin feeding. Enterocyte sexual identity, determined by transformerFemale expression, dictates sexually dimorphic cell size, H3/H4-Bchs expression, basal rates of autophagy, fecundity, intestinal homeostasis and lifespan extension in response to rapamycin. Dimorphism in autophagy is conserved in mice, where intestine, brown adipose tissue and muscle exhibit sex differences in autophagy and response to rapamycin. This study highlights tissue sex as a determining factor in the regulation of metabolic processes by mTOR and the efficacy of mTOR-targeted, anti-aging drug treatments

    Scalar field cosmology in the energy phase-space -- unified description of dynamics

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    In this letter we apply dynamical system methods to study all evolutional paths admissible for all initial conditions of the FRW cosmological model with a non-minimally coupled to gravity scalar field and a barotropic fluid. We choose "energy variables" as phase variables. We reduce dynamics to a 3-dimensional dynamical system for an arbitrary potential of the scalar field in the phase space variables. After postulating the potential parameter Γ\Gamma as a function of λ\lambda (defined as V/V-V'/V) we reduce whole dynamics to a 3-dimensional dynamical system and study evolutional paths leading to current accelerating expansion. If we restrict the form of the potential then we will obtain a 2-dimensional dynamical system. We use the dynamical system approach to find a new generic quintessence scenario of approaching to the de Sitter attractor which appears only for the case of non-vanishing coupling constant.Comment: revtex4, 16 pages, 3 figs; (v2) refs. added, published versio

    A posteriori

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    Intermediate inflation and the slow-roll approximation

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    It is shown that spatially homogeneous solutions of the Einstein equations coupled to a nonlinear scalar field and other matter exhibit accelerated expansion at late times for a wide variety of potentials VV. These potentials are strictly positive but tend to zero at infinity. They satisfy restrictions on V/VV'/V and V/VV''/V' related to the slow-roll approximation. These results generalize Wald's theorem for spacetimes with positive cosmological constant to those with accelerated expansion driven by potentials belonging to a large class.Comment: 19 pages, results unchanged, additional backgroun

    Transcatheter Aortic Valve Implantation in Dialysis Patients

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    Background/Aims: Transcatheter aortic valve implantation (TAVI) has emerged as a new therapeutic option for high-risk patients. However, dialysis patients were excluded from all previous studies. The aim of this study is to compare the outcomes of TAVI for dialysis patients with those for patients with chronic kidney disease (CKD) stages 3 and 4 and to compare TAVI with open surgery in dialysis patients. Methods: Part I: comparison of 10 patients on chronic hemodialysis with 116 patients with non-dialysis-dependent CKD undergoing TAVI. Part II: comparison of transcatheter (n = 15) with open surgical (n = 24) aortic valve replacement in dialysis patients. Results: Part I: dialysis patients were significantly younger (72.3 vs. 82.0 years; p < 0.01). Hospital stay was significantly longer in dialysis patients (21.8 vs. 12.1 days; p = 0.01). Overall 30-day mortality was 3.17%, with no deaths among dialysis patients. Six-month survival rates were similar (log-rank p = 0.935). Part II: patient age was comparable (66.5 vs. 69.5 years; p = 0.42). Patients in the surgical group tended to stay longer in hospital than TAVI patients (29.5 vs. 22.5 days; p = 0.35). Conclusion: TAVI is a safe procedure in patients on chronic hemodialysis. Until new data become available, we find no compelling reason to refuse these patients TAVI. Copyright (C) 2012 S. Karger AG, Base
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