1,048 research outputs found
Synthesis and crystal structure of unexpected (1S,4R,5R,6S)-4-cyano-2,2,6-trimethyl-3-azabicyclo[3.3.1]nonan-6-yl acetate
The reaction of (-)-β-pinene with KCN under a mild bridged Ritter reaction gave (1S,5R,6S)-2,2,6-trimethyl-3-aza-bicyclo[3.3.1]non-3-en-6-yl acetate that subsequently reacted to provide an unexpected (1S,4R,5R,6S)-4-cyano-2,2,6-trimethyl-3-azabicyclo[3.3.1]nonane-6-yl acetate. The structure of the compound was determined by high-resolution mass spectrometry, and IR and NMR spectroscopy and confirmed by single crystal X-ray crystallography. The compound crystallises in the monoclinic P21 space group, with unit cell parameters a 8.6120 (17), b 7.4570 (15), c 11.189 (2) Å, and β 110.16 (3)°
The shape of a moving fluxon in stacked Josephson junctions
We study numerically and analytically the shape of a single fluxon moving in
a double stacked Josephson junctions (SJJ's) for various junction parameters.
We show that the fluxon in a double SJJ's consists of two components, which are
characterized by different Swihart velocities and Josephson penetration depths.
The weight coefficients of the two components depend on the parameters of the
junctions and the velocity of the fluxon. It is shown that the fluxon in SJJ's
may have an unusual shape with an inverted magnetic field in the second
junction when the velocity of the fluxon is approaching the lower Swihart
velocity. Finally, we study the influence of fluxon shape on flux-flow
current-voltage characteristics and analyze the spectrum of Cherenkov radiation
for fluxon velocity above the lower Swihart velocity. Analytic expression for
the wavelength of Cherenkov radiation is derived.Comment: 12 pages, 12 figure
Regulation of Marginal Zone B-Cell Differentiation by MicroRNA-146a.
B-cell development in the bone marrow is followed by specification into functional subsets in the spleen, including marginal zone (MZ) B-cells. MZ B-cells are classically characterized by T-independent antigenic responses and require the elaboration of distinct gene expression programs for development. Given their role in gene regulation, it is not surprising that microRNAs are important factors in B-cell development. Recent work demonstrated that deficiency of the NFÎşB feedback regulator, miR-146a, led to a range of hematopoietic phenotypes, but B-cell phenotypes have not been extensively characterized. Here, we found that miR-146a-deficient mice demonstrate a reduction in MZ B-cells, likely from a developmental block. Utilizing high-throughput sequencing and comparative analysis of developmental stage-specific transcriptomes, we determined that MZ cell differentiation was impaired due to decreases in Notch2 signaling. Our studies reveal miR-146a-dependent B-cell phenotypes and highlight the complex role of miR-146a in the hematopoietic system
Enhanced Transmission of Light and Particle Waves through Subwavelength Nanoapertures by Far-Field Interference
Subwavelength aperture arrays in thin metal films can enable enhanced
transmission of light and matter (atom) waves. The phenomenon relies on
resonant excitation and interference of the plasmon or matter waves on the
metal surface. We show a new mechanism that could provide a great resonant and
nonresonant transmission enhancement of the light or de Broglie particle waves
passed through the apertures not by the surface waves, but by the constructive
interference of diffracted waves (beams generated by the apertures) at the
detector placed in the far-field zone. In contrast to other models, the
mechanism depends neither on the nature (light or matter) of the beams
(continuous waves or pulses) nor on material and shape of the multiple-beam
source (arrays of 1-D and 2-D subwavelength apertures, fibers, dipoles or
atoms). The Wood anomalies in transmission spectra of gratings, a long standing
problem in optics, follow naturally from the interference properties of our
model. The new point is the prediction of the Wood anomaly in a classical
Young-type two-source system. The new mechanism could be interpreted as a
non-quantum analog of the superradiance emission of a subwavelength ensemble of
atoms (the light power and energy scales as the number of light-sources
squared, regardless of periodicity) predicted by the well-known Dicke quantum
model.Comment: Revised version of MS presented at the Nanoelectronic Devices for
Defense and Security (NANO-DDS) Conference, 18-21 June, 2007, Washington, US
An Exploratory Investigation of Animal Hoarding Symptoms in a Sample of Adults Diagnosed With Hoarding Disorder
Objective: The extant research on animal hoarding has a dearth of information on animal hoarding tendencies in adults diagnosed with hoarding disorder (HD). In the present study, we investigated possible recurrent animal hoarding behavioral and symptom patterns in individuals diagnosed with hoarding disorder. Methods: Hoarding severity scores from baseline assessments for 65 community-dwelling adults diagnosed with HD were analyzed with respect to their present and past animal ownership characteristics. Results: Approximately half of participants reported currently owning pets, and pet owners in the sample reported currently owning an average of two pets. Of the participants who reported currently owning animals, 10% reported having no rules for their pets’ behaviors, 51% reported having made at least one sacrifice for their pets, 54% reported having had at least one pet in childhood, and 29% reported that they believed they have a “special ability” to communicate with their pets. The results of the present study suggest that animal hoarding is not necessarily present in individuals diagnosed with HD.
Conclusion: No significant associations of current pet ownership characteristics with present hoarding severity were observed. Reported maximum number of pets owned in childhood was significantly correlated with present object hoarding symptom severity
Influence of the anion potential on the charge ordering in quasi-one dimensional charge transfer salts
We examine the various instabilities of quarter-filled strongly correlated
electronic chains in the presence of a coupling to the underlying lattice. To
mimic the physics of the (TMTTF)X Bechgaard-Fabre salts we also include
electrostatic effects of intercalated anions. We show that small displacements
of the anion can stabilize new mixed Charged Density Wave-Bond Order Wave
phases in which central symmetry centers are suppressed. This finding is
discussed in the context of recent experiments. We suggest that the recently
observed charge ordering is due to a cooperative effect between the Coulomb
interaction and the coupling of the electronic stacks to the anions. On the
other hand, the Spin-Peierls instability at lower temperature requires a
Peierls-like lattice coupling.Comment: Latex, 4 pages, 4 postscript figure
Preliminary Design of Reactive Distillation Columns
A procedure that combines feasibility analysis, synthesis and design of reactive distillation columns is introduced. The main interest of this methodology lies on a progressive
introduction of the process complexity. From minimal information concerning the physicochemical properties of the system, three steps lead to the design of
the unit and the specification of its operating conditions. Most of the methodology exploits and enriches approaches found in the literature. Each step is described and our contribution is underlined. Its application is currently limited to equilibrium reactive systems where degree of freedom is equal to 2 or less than 2. This methodology which provides a reliable initialization point for the optimization of the process has been applied with success to
different synthesis. The production of methyl-tert-butyl-ether (MTBE) and methyl acetate are presented as examples
Kinetic Selectivity of Olefin Metathesis Catalysts Bearing Cyclic (Alkyl)(Amino)Carbenes
The evaluation of ruthenium olefin metathesis catalysts 4–6 bearing cyclic (alkyl)(amino)carbenes (CAACs) in the cross-metathesis of cis-1,4-diacetoxy-2-butene (7) with allylbenzene (8) and the ethenolysis of methyl oleate (11) is reported. Relative to most NHC-substituted complexes, CAAC-substituted catalysts exhibit lower E/Z ratios (3:1 at 70% conversion) in the cross-metathesis of 7 and 8. Additionally, complexes 4–6 demonstrate good selectivity for the formation of terminal olefins versus internal olefins in the ethenolysis of 11. Indeed, complex 6 achieved 35 000 TONs, the highest recorded to date. CAAC-substituted complexes exhibit markedly different kinetic selectivity than most NHC-substituted complexes
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