420 research outputs found
APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination
Antibody class switch recombination (CSR) occurs by an intrachromosomal deletion requiring generation of double-stranded breaks (DSBs) in switch-region DNA. The initial steps in DSB formation have been elucidated, involving cytosine deamination by activation-induced cytidine deaminase and generation of abasic sites by uracil DNA glycosylase. However, it is not known how abasic sites are converted into single-stranded breaks and, subsequently, DSBs. Apurinic/apyrimidinic endonuclease (APE) efficiently nicks DNA at abasic sites, but it is unknown whether APE participates in CSR. We address the roles of the two major mammalian APEs, APE1 and APE2, in CSR. APE1 deficiency causes embryonic lethality in mice; we therefore examined CSR and DSBs in mice deficient in APE2 and haploinsufficient for APE1. We show that both APE1 and APE2 function in CSR, resulting in the DSBs necessary for CSR and thereby describing a novel in vivo function for APE2
Hierarchical Equations of Motion Approach to Quantum Thermodynamics
We present a theoretical framework to investigate quantum thermodynamic
processes under non-Markovian system-bath interactions on the basis of the
hierarchical equations of motion (HEOM) approach, which is convenient to carry
out numerically "exact" calculations. This formalism is valuable because it can
be used to treat not only strong system-bath coupling but also system-bath
correlation or entanglement, which will be essential to characterize the heat
transport between the system and quantum heat baths. Using this formalism, we
demonstrated an importance of the thermodynamic effect from the tri-partite
correlations (TPC) for a two-level heat transfer model and a three-level
autonomous heat engine model under the conditions that the conventional quantum
master equation approaches are failed. Our numerical calculations show that TPC
contributions, which distinguish the heat current from the energy current, have
to be take into account to satisfy the thermodynamic laws.Comment: 9 pages, 4 figures. As a chapter of: F. Binder, L. A. Correa, C.
Gogolin, J. Anders, and G. Adesso (eds.), "Thermodynamics in the quantum
regime - Recent Progress and Outlook", (Springer International Publishing
The Role of Parvalbumin-positive Interneurons in Auditory Steady-State Response Deficits in Schizophrenia
© The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Despite an increasing body of evidence demonstrating subcellular alterations in parvalbumin-positive (PV+) interneurons in schizophrenia, their functional consequences remain elusive. Since PV+ interneurons are involved in the generation of fast cortical rhythms, these changes have been hypothesized to contribute to well-established alterations of beta and gamma range oscillations in patients suffering from schizophrenia. However, the precise role of these alterations and the role of different subtypes of PV+ interneurons is still unclear. Here we used a computational model of auditory steady-state response (ASSR) deficits in schizophrenia. We investigated the differential effects of decelerated synaptic dynamics, caused by subcellular alterations at two subtypes of PV+ interneurons: basket cells and chandelier cells. Our simulations suggest that subcellular alterations at basket cell synapses rather than chandelier cell synapses are the main contributor to these deficits. Particularly, basket cells might serve as target for innovative therapeutic interventions aiming at reversing the oscillatory deficits.Peer reviewe
Double Spin Asymmetry of Electrons from Heavy Flavor Decays in p+p Collisions at sqrt(s)=200 GeV
We report on the first measurement of double-spin asymmetry, A_LL, of
electrons from the decays of hadrons containing heavy flavor in longitudinally
polarized p+p collisions at sqrt(s)=200 GeV for p_T= 0.5 to 3.0 GeV/c. The
asymmetry was measured at mid-rapidity (|eta|<0.35) with the PHENIX detector at
the Relativistic Heavy Ion Collider. The measured asymmetries are consistent
with zero within the statistical errors. We obtained a constraint for the
polarized gluon distribution in the proton of |Delta g/g(log{_10}x=
-1.6^+0.5_-0.4, {mu}=m_T^c)|^2 < 0.033 (1 sigma), based on a leading-order
perturbative-quantum-chromodynamics model, using the measured asymmetry.Comment: 385 authors, 17 pages, 15 figures, 5 tables. Submitted to Phys. Rev.
D. Plain text data tables for the points plotted in figures for this and
previous PHENIX publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
Quadrupole Anisotropy in Dihadron Azimuthal Correlations in Central Au Collisions at =200 GeV
The PHENIX collaboration at the Relativistic Heavy Ion Collider (RHIC)
reports measurements of azimuthal dihadron correlations near midrapidity in
Au collisions at =200 GeV. These measurements
complement recent analyses by experiments at the Large Hadron Collider (LHC)
involving central Pb collisions at =5.02 TeV, which
have indicated strong anisotropic long-range correlations in angular
distributions of hadron pairs. The origin of these anisotropies is currently
unknown. Various competing explanations include parton saturation and
hydrodynamic flow. We observe qualitatively similar, but larger, anisotropies
in Au collisions compared to those seen in Pb collisions at the
LHC. The larger extracted values in Au collisions at RHIC are
consistent with expectations from hydrodynamic calculations owing to the larger
expected initial-state eccentricity compared with that from Pb
collisions. When both are divided by an estimate of the initial-state
eccentricity the scaled anisotropies follow a common trend with multiplicity
that may extend to heavy ion data at RHIC and the LHC, where the anisotropies
are widely thought to arise from hydrodynamic flow.Comment: 375 authors, 7 pages, 5 figures. Published in Phys. Rev. Lett. v2 has
minor changes to text and figures in response to PRL referee suggestions.
Plain text data tables for the points plotted in figures for this and
previous PHENIX publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
Cross section for production via dielectrons in dAu collisions at GeV
We report a measurement of pairs from semileptonic heavy-flavor
decays in Au collisions at GeV. Exploring the mass
and transverse-momentum dependence of the yield, the bottom decay contribution
can be isolated from charm, and quantified by comparison to {\sc pythia} and
{\sc mc@nlo} simulations. The resulting -production cross section is
~mb, which is equivalent to a nucleon-nucleon cross section of
b.Comment: 375 authors, 16 pages, 8 figures, 7 tables, 2008 data. Submitted to
Phys. Rev. C Plain text data tables for the points plotted in figures for
this and previous PHENIX publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
Transverse-Momentum Dependence of the J/psi Nuclear Modification in d+Au Collisions at sqrt(s_NN)=200 GeV
We present measured J/psi production rates in d+Au collisions at sqrt(s_NN) =
200 GeV over a broad range of transverse momentum (p_T=0-14 GeV/c) and rapidity
(-2.2<y<2.2). We construct the nuclear-modification factor R_dAu for these
kinematics and as a function of collision centrality (related to impact
parameter for the R_dAu collision). We find that the modification is largest
for collisions with small impact parameters, and observe a suppression
(R_dAu<1) for p_T<4 GeV/c at positive rapidities. At negative rapidity we
observe a suppression for p_T1) for p_T>2
GeV/c. The observed enhancement at negative rapidity has implications for the
observed modification in heavy-ion collisions at high p_T.Comment: 384 authors, 24 pages, 19 figures, 13 tables. Submitted to Phys. Rev.
C. Plain text data tables for the points plotted in figures for this and
previous PHENIX publications are publicly available at
http://www.phenix.bnl.gov/phenix/WWW/info/data/ppg123_data.htm
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