Phytochemical and antibacterial analysis of two morpho-types of Solanum melongena var. insanum (L.) Prain. an ayrvedic herb

The Solanaceae, one of the largest family in angiosperms have high commercial value. The genus Solanum in Solanaceae is a complex one. Many species in Solanum does not contain a well-defined species boundaries. Many of them with taxonomical controversies. The present study was about such a Solanum species – Solanum melongena var. insanum. There were two morpho-types which are botanically known as S. melongena var. insanum. In Ayurveda both of them were treated as separate plants – as „Cheruvazhuthina‟ and „Punyahachunda‟. „Cheruvazhuthina‟ was extensively used in Ayurveda but „Punyahachunda‟ was not. Roots of „Punyahachunda‟ was used instead in the unavailability of roots of „Cheruvazhuthina‟. So this study was aimed to analyse the pharmacognostic properties of both morpho-types. The therapeutic value was assayed by antibacterial activity of roots of both plants. For convenience the two plants viz., „Cheruvazhuthina‟ and „Punyahachunda‟ were denoted as morpho-type 1 and morpho-type 2 respectively. Phytochemical profiling revealed significant differences in certain components. Hence the samples were subjected for FT-IR analyses and the spectra showed high pattern of similarity as well as differences in both the morpho-types investigated. Phytochemical profile was prepared for both the morpho-types which were further fractionated by chromatography. The fractionated components were subjected for bioassay against the growth inhibition of E. coli. The bioassay results revealed that the therapeutic potency of morpho-type 1 was more significant and hence I recommend the use of morphote type 1. However a detailed phytochemical as well as molecular profiling is warranted to confirm the recently obtained results

Unusual case of tubercular peritonitis

An interesting case of Pelvic Tubercular Peritonitis, post MTP and IUCD insertion presenting as Severe Sepsis. Managed aggressively with Fluid, supportive measures and complete course of ATT. Case is being reported as an unusual complication post MTP and incidental reports in literature of spread of Pelvic Peritonitis in preexisting Genital Tuberculosis by haematogenous spread

A case of recurrent thanatophoric dwarfism

An interesting case of Recurrent Thanatophoric Dwarfism in a Multigravida; reporting to this hospital in second trimester which was terminated. It was confirmed on anomalies scan and was lethal. Genetic testing of the couple was advised; however, they refused and were lost to follow up. Long-term survivors are rare and require aggressive intervention for complications. In such cases couple should be informed of prognosis and extensively counselled for termination based on complications in long-term survivors as reported in literature. Management should be done after counselling and consultation regarding complications, clinical course, and prognosis of the condition. Due considerations may be given based on the parent’s desire for extreme life-support measures based on availability and affordability for provision of comfort care for the newborn. End of Life Support issues should be considered based on prevailing laws governing the nation

Ideals as generalized prime ideal factorization of submodules

For a submodule $N$ of an $R$-module $M$, a unique product of prime ideals in $R$ is assigned, which is called the generalized prime ideal factorization of $N$ in $M$, and denoted as ${\mathcal{P}}_M(N)$. But for a product of prime ideals ${{{\mathfrak{p}}_1} \cdots {{\mathfrak{p}}_{n}}}$ in $R$ and an $R$-module $M$, there may not exist a submodule $N$ in $M$ with ${\mathcal{P}}_{M}(N) = {{{\mathfrak{p}}_1} \cdots {{\mathfrak{p}}_{n}}}$. In this article, for an arbitrary product of prime ideals ${{{\mathfrak{p}}_1} \cdots {{\mathfrak{p}}_{n}}}$ and a module $M$, we find conditions for the existence of submodules in $M$ having ${{{\mathfrak{p}}_1} \cdots {{\mathfrak{p}}_{n}}}$ as their generalized prime ideal factorization

A case of multiple fibroid uterus, complete placenta praevia, antepartum haemorrhage, myomectomy and obstetric hysterectomy: a near miss

An interesting case of young unbooked, unregistered, primigravida with multiple fibroid uterus, placenta praevia type IV, presented with APH in haemorrhagic Shock, impacted large fibroid in Lower Uterine Segment and Multiple fibroids on Anterior wall, fundus for which myomectomy was performed. Preterm Caesarean Section with extremely low birth weight infant delivered followed by life-saving Emergency Obstetric hysterectomy. She had uneventful recovery without any complications of massive transfusion or surgery. Case is being reported as an obstetric near miss

The role of outcome expectancy in therapeutic change across psychotherapy versus pharmacotherapy for depression.

BACKGROUND: Patient outcome expectancy - the belief that treatment will lead to an improvement in symptoms - is linked to favourable therapeutic outcomes in major depressive disorder (MDD). The present study extends this literature by investigating the temporal dynamics of expectancy, and by exploring whether expectancy during treatment is linked to differential outcomes across treatment modalities, for both optimistic versus pessimistic expectancy. METHODS: A total of 104 patients with MDD were randomized to receive either cognitive behavioral therapy (CBT) or pharmacotherapy for 16 weeks. Outcome expectancy was measured throughout treatment using the Depression Change Expectancy Scale (DCES). Depression severity was measured using both the Hamilton Depression Rating Scale and Beck Depression Inventory-II. RESULTS: Latent growth curve models supported improvement in expectancy across both treatments. Cross-lagged panel models revealed that both higher optimistic and lower pessimistic expectancy at mid-treatment predicted greater treatment response in pharmacotherapy. For CBT, the associative patterns between expectancy and depression differed as a function of expectancy type; higher optimistic expectancy at pre-treatment and lower pessimistic expectancy at mid-treatment predicted greater treatment response. LIMITATIONS: The sample size limited statistical power and the complexity of models that could be explored. CONCLUSIONS: Results suggest that outcome expectancy improved during treatment for depression. Whether outcome expectancy represents a specific mechanism for the reduction of depression warrants further investigation

Molecular-genetic characterization of human parvovirus B19 prevalent in Kerala State, India

peer-reviewedBackground Human parvovirus B19V is a DNA virus, and a member of the family Parvoviridae, that causes various clinical manifestations, from asymptomatic to persistent infection that is associated with different autoimmune diseases. The parvovirus B19 evolves with a very high mutation rate that is closer to those of existing RNA viruses. Globally circulating B19V is currently classified into three genotypes, but their distribution is not spatially and temporally correlated. Except for a few recent reports on B19V entry into the human host and its genetic diversity, there is a lack of sufficient studies on this virus from distinct geographical locations and no clear understanding of its evolution has been documented. Methods To better understand the evolution of the Human parvo B19V virus from India's southern part, a geographically distinct location with no reports of B19V genomes, we have screened for B19V in 456 suspected cases using VP1/2 surface marker genes, and its characteristics were studied in detail. Amongst 456 clinically suspected B19V samples, 7.2% (33/456) were found positive by nested PCR (nPCR) were subsequently validated by real-time PCR, Sanger sequencing, and metagenome analysis. Results Human parvovirus B19 infection was shown among 33 of 456 patients when tested by nPCR; 30 among these were also positive by qPCR and were subsequently confirmed by sequencing 75% nPCR positive samples and 76% qPCR positive samples were from patients with age. ≥ 50 years respectively (Additional file 1: Table S1). The complete VP1/2 gene assembly from the South Indian strain showed three novel mutations (T122A, V128I, I283V), which might significantly impact the stability and virulence of the B19V virus circulating in this part of the world. These mutations might be crucial for its adaptive evolutionary strategies facilitating the spread and infectivity potential of the virus. In maximum likelihood phylogeny of VP1/2 sequences, the South Indian B19V strain forms a separate clade closer to the existing genotype two strains circulating worldwide. Conclusion Our study contributes to a better understanding of the human parvovirus's genetic and evolutionary characteristics in South India. Also, it highlights the possibility that a positive selection pressure acting on VP1/2 could increase the survival and replication capabilities of the viruses

Visual similarity effects on short-term memory for order: The case of verbally labeled pictorial stimuli

Four experiments examined the effect of visual similarity on immediate memory for order. Experiments 1 and 2 used easily nameable line drawings. Following a sequential presentation in either silent or suppression conditions, participants were presented with the drawings in a new, random order and were required to remember their original serial position. In Experiment 3, participants first learned to associate a verbal label with an abstract matrix pattern. Then they completed an immediate memory task in which they had to name the matrices aloud during presentation. At recall, the task required remembering either the order of the matrices or the order of their names. In Experiment 4, participants learned to associate nonword labels with schematic line drawings of faces; the phonemic similarity of the verbal labels was also manipulated. All four experiments indicate that the representations supporting performance comprise both verbal and visual features. The results are consistent with a multiattribute encoding view

Nucleophilic Functionalization of the Calix[6]arene Para- and Meta-Position via p‑Bromodienone Route

It is here demonstrated that the p-bromodienone route, previously reported for calix[4]arenes, is also effective for the functionalization of the calix[6]arene macrocycle. Thus, alcoholic O-nucleophiles can be introduced at the calix[6]arene exo rim. In addition, the reaction of a calix[6]arene p-bromodienone derivative with an actived aromatic substrate, such as resorcinol, led to the first example of a meta-functionalized, inherently chiral calix[6]arene derivativ