Amelioration of Paracetamol-Induced Hepatotoxicity in Rat by the Administration of Chloroform extract of Argemone mexicana

Aim: The present study was undertaken to examine the effects of Chloroform extract of Argemone mexicana using the paracetamol-induced liver damage in rats as the animal model. Materials and methods: Chloroform extract of Argemone mexicana (100 and 200 mg/kg body weight) was administered daily in experimental animals. The hepatoprotective efficacy of Chloroform extract of Argemone mexicana (100 and 200 mg/kg) was investigated against paracetamol-induced hepatotoxicity. The levels of serum glutamic oxaloacetic transaminase (SGOT), serum glutamic-pyruvic transaminase (SGPT), serum alkaline phosphatase (ALP), bilirubin and triglycerides were estimated. Moreover, chloroform extract of Argemone mexicana -aided antioxidant defense against hepatotoxic insult of paracetamol was measured by evaluating a number of anti-oxidative biomarkers including reduced malondialdehyde (MDA) in the serum. Results: Oral administration of paracetamol (500 mg/kg b.wt.) resulted in a significant elevation of liver enzymes in serum such as SGOT, SGPT, ALP, bilirubin and triglyceride levels when compared with the results in the control group. As regards oxidative stress biomarkers, there were increased tissue levels of malondialdehyde in the group treated with paracetamol. All of these results were ameliorated by co-administration of chloroform extract of Argemone mexicana. Conclusions: These results suggest that the protective role of Chloroform extract of Argemone mexicana in the prevention of PCM-induced hepatic toxicity in rats was associated with a decrease of oxidative stress in hepatic tissues. Keywords: Antihepatotoxicity; Chloroform extract of Argemone mexicana; Paracetamo

Identification of a biomarker panel for improvement of prostate cancer diagnosis by volatile metabolic profiling of urine

Background: The lack of sensitive and specific biomarkers for the early detection of prostate cancer (PCa) is a major hurdle to improve patient management. Methods: A metabolomics approach based on GC-MS was used to investigate the performance of volatile organic compounds (VOCs) in general and, more specifically, volatile carbonyl compounds (VCCs) present in urine as potential markers for PCa detection. Results: Results showed that PCa patients (n = 40) can be differentiated from cancer-free subjects (n = 42) based on their urinary volatile profile in both VOCs and VCCs models, unveiling significant differences in the levels of several metabolites. The models constructed were further validated using an external validation set (n = 18 PCa and n = 18 controls) to evaluate sensitivity, specificity and accuracy of the urinary volatile profile to discriminate PCa from controls. The VOCs model disclosed 78% sensitivity, 94% specificity and 86% accuracy, whereas the VCCs model achieved the same sensitivity, a specificity of 100% and an accuracy of 89%. Our findings unveil a panel of 6 volatile compounds significantly altered in PCa patients' urine samples that was able to identify PCa, with a sensitivity of 89%, specificity of 83%, and accuracy of 86%. Conclusions: It is disclosed a biomarker panel with potential to be used as a non-invasive diagnostic tool for PCa.info:eu-repo/semantics/publishedVersio

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Not AvailableSeven year old vines of Tas-A-Ganesh grapes (Vitis vinifera L.) grafted on Dog Ridge rootstock (Vitis champani) were shoot thinned for three years continuously with different shoot retention treatments viz., 30, 45, 60 and 75 shoots per vine. The forward pruning of vines was carried out during the month of October. The shoot length, cane diameter and inter nodal length was measured to study the relation with bunch characters. The vines having 30 shoots had the highest shoot length, cane diameter, internode length and leaf area per shoot as compared to the other treatments. The increase in number of shoots per vine from 30 to 75 resulted into increase in yield per vine but reduced the berry diameter. The data recorded on various parameters suggests that to achieve the exportable quality bunches, the number of bunches per vine needs to be standardized. The relationship between LAI and brix yield suggested the importance of LAI studies in canopy management for yield and quality improvement.Not Availabl

STUDY ON IMPROVING PERFORMANCE OF SOLAR COOKER BY USING DIFFERENT COATING MATERIAL

Day by day demand of the energy increasing in all over the world. Solar energy is very large, in exhaustible source of energy. The use of renewable energy is receiving growing interest worldwide. Everybody demand clean and safe energy devices with cost effective. One of the most essential energy needs for human living is for cooking. In India mostly rural sector uses Biogas, Kerosene, and LPG for cooking. According to the World Health Organization comparative risk study, exposure to smoke from household use of solid fuels is responsible for the premature deaths of approximate 400000 women in India every year.Also in solar cooker device if black material coating is done for receiver it improves the efficiency of system and it also increases the temperature of cooker for cooking. Black coating improves the absorbptance of the receiver surface. This project paper is Improving performance of solar cooker by using different coating material

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Not AvailableThe root distribution pattern of 3 grape rootstocks, Dog Ridge, Salt Creek, and St. George, grafted with Thompson Seedless grapevine was studied at the National Research Centre for Grapes in Pune, India. The soil is heavy black cotton soil (vertisol) with a pH of> 8.0. Roots of different thicknesses ( 10 mm) were examined at horizontal distances of 0-30 cm, 31-60 cm, 61-90 cm, 91-120 cm, and 121-150 cm away from the trunk and also to depths of 0-30 cm, 31-60 cm, and 61-90 cm from the surface. Among the different categories of roots, Dog Ridge put forth the maximum root length in the 10 mm) up to a 60-cm distance, beyond which there was no spread in any of the rootstocks. At a depth of 0-30 cm, Dog Ridge put forth the greatest root mass, followed by Salt Creek and St. George. However, the highest root mass was recorded in all of the rootstocks at depths of 31-60 cm. Dry matter accumulation was highest in Thompson Seedless grafted on Dog Ridge, and Salt Creek was next. Dog Ridge rootstock grafted vines had more dry matter in the roots, trunk, primary arms, and canes while St. George had the least dry matter in roots.Not Availabl

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Not AvailableThe variations in growth, powdery mildew and anthracnose incidence and biochemical changes in Thompson Seedless grapevines grafted onto Dogridge and 110-R rootstocks in comparision to own rooted grape vines was investigated.Not Availabl

Study On Improving Performance Of Solar Cooker By Using Different Coating Material

Day by day demand of the energy increasing in all over the world. Solar energy is very large, in exhaustible source of energy. The use of renewable energy is receiving growing interest worldwide. Everybody demand clean and safe energy devices with cost effective. One of the most essential energy needs for human living is for cooking. In India mostly rural sector uses Biogas, Kerosene, and LPG for cooking. According to the World Health Organization comparative risk study, exposure to smoke from household use of solid fuels is responsible for the premature deaths of approximate 400000 women in India every year.Also in solar cooker device if black material coating is done for receiver it improves the efficiency of system and it also increases the temperature of cooker for cooking. Black coating improves the absorbptance of the receiver surface. This project paper is Improving performance of solar cooker by using different coating material