Worden psychofarmaca in het verpleeghuis te vaak voorgeschreven?

Worden psychofarmaca in verpleeghuizen te vaak voorgeschreven? Onder deze titel publiceerden collega’s Ribbe en Hertogh in 1993 een artikel in het Nederlands Tijdschrift voor Geneeskunde. 1 Hoewel zij geen antwoord geven op hun normatieve vraag in de titel, houden zij wel een pleidooi voor de combinatie van een medicamenteuze en niet-medicamenteuze behandeling. Met name de niet-medicamenteuze benadering, die doorgaans door de verzorgenden wordt toegepast, heeft een ‘draagkrachtversterkend’ effect, waarbij niet zozeer het gedrag van de patiënt verandert, aldus de auteurs, als wel de kwalificatie daarvan als ‘problematisch’

Bounds on long-lived charged massive particles from Big Bang nucleosynthesis

The Big Bang nucleosynthesis (BBN) in the presence of charged massive particles (CHAMPs) is studied in detail. All currently known effects due to the existence of bound states between CHAMPs and nuclei, including possible late-time destruction of Li6 and Li7 are included. The study sets conservative bounds on CHAMP abundances in the decay time range 3x10^2 sec - 10^12 sec. It is stressed that the production of Li6 at early times T ~ 10keV is overestimated by a factor ~ 10 when the approximation of the Saha equation for the He4 bound state fraction is utilised. To obtain conservative limits on the abundance of CHAMPs, a Monte-Carlo analysis with ~ 3x10^6 independent BBN runs, varying reaction rates of nineteen different reactions, is performed (see attached erratum, however). The analysis yields the surprising result that except for small areas in the particle parameter space conservative constraints on the abundance of decaying charged particles are currently very close to those of neutral particles. It is shown that, in case a number of heretofore unconsidered reactions may be determined reliably in future, it is conceivable that the limit on CHAMPs in the early Universe could be tightened by orders of magnitude. An ERRATUM gives limits on primordial CHAMP densities when the by Ref. Kamimura et al. recently more accurately determined CHAMP reaction rates are employed.Comment: includes Erratum showing most up to date limits after determination of the most important reaction rate

Golden gravitational lensing systems from the Sloan Lens ACS Survey. I. SDSS J1538+5817: one lens for two sources

We present a lensing and photometric study of the exceptional system SDSS J1538+5817, identified by the SLACS survey. The lens is a luminous elliptical at redshift z=0.143. Using HST public images in two different filters, the presence of two background sources lensed into an Einstein ring and a double system is ascertained. Our new spectroscopic observations, performed at the NOT, reveal that the two sources are located at the same redshift z=0.531. We investigate the total mass distribution of the lens between 1 and 4 kpc from the galaxy center by means of parametric and non-parametric lensing codes that describe the multiple images as point-like objects. Several disparate lensing models agree on: (1) reproducing accurately the observed image positions; (2) predicting a nearly axisymmetric total mass distribution, centered and oriented as the light distribution; (3) measuring a value of 8.11 x 10^{10} M_{Sun} for the total mass projected within the Einstein radius of 2.5 kpc; (4) estimating a total mass density profile slightly steeper than an isothermal one. A fit of the SDSS multicolor photometry with CSP models provides a value of 20 x 10^{10} M_{Sun} for the total stellar mass of the galaxy and of 0.9 for the fraction of projected luminous over total mass enclosed inside the Einstein radius. By combining lensing and photometric mass measurements, we differentiate the lens mass content in terms of luminous and dark matter components. This two-component modeling, which is viable only in extraordinary systems like SDSS J1538+5817, leads to a description of the global properties of the galaxy dark matter halo. Extending these results to a larger number of lenses would improve considerably our understanding of galaxy formation and evolution processes in the LCDM scenario.Comment: 21 pages, 16 figures, accepted by The Astrophysical Journa

CLASS B1152+199 and B1359+154: Two New Gravitational Lens Systems Discovered in the Cosmic Lens All-Sky Survey

The third phase of the Cosmic Lens All-Sky Survey (CLASS) has recently been completed, bringing the total number of sources imaged to over 15000 in the CLASS and JVAS combined survey. In the VLA observations carried out in March and April of 1998, two new candidate lensed systems were discovered: CLASS B1152+199 and B1359+154. B1152+199 is a 1.6 arcsecond double, with a background quasar at z=1.019 lensed by a foreground galaxy at z=0.439. The relatively flat radio spectra of the lensed images, combined with a previous ROSAT detection of the source, make B1152+199 a strong candidate for time delay studies at both radio and X-ray wavelengths. B1359+154 is a quadruply lensed quasar at z=3.235, with a maximum image separation of 1.7 arcseconds. As yet, the redshift of the lensing object in this system is undetermined. The steep spectral index of the source suggests that B1359+154 will not exhibit strong variability, and is therefore unlikely to be useful for determining the Hubble constant from measured time delays.Comment: accepted for publication in The Astronomical Journa

Parametric hazard rate models for long-term sickness absence

PURPOSE: In research on the time to onset of sickness absence and the duration of sickness absence episodes, Cox proportional hazard models are in common use. However, parametric models are to be preferred when time in itself is considered as independent variable. This study compares parametric hazard rate models for the onset of long-term sickness absence and return to work. METHOD: Prospective cohort study on sickness absence with four follow-up years of 53,830 employees working in the private sector in the Netherlands. The time to onset of long-term (>6 weeks) sickness absence and return to work were modelled by parametric hazard rate models. RESULTS: The exponential parametric model with a constant hazard rate most accurately described the time to onset of long-term sickness absence. Gompertz-Makeham models with monotonically declining hazard rates best described return to work. CONCLUSIONS: Parametric models offer more possibilities than commonly used models for time-dependent processes as sickness absence and return to work. However, the advantages of parametric models above Cox models apply mainly for return to work and less for onset of long-term sickness absence

The new two-image gravitational lens system CLASS B2319+051

We report the discovery of a new two-image gravitational lens system from the Cosmic Lens All-Sky Survey, CLASS B2319+051. Radio imaging with the Very Large Array (VLA) and Multi-Element Radio-Linked Interferometer Network (MERLIN) shows two compact components with a flux density ratio of 5:1, separated by 1.36 arcsec. Observations with the Very Long Baseline Array (VLBA) resolve each of the radio components into a pair of parity-reversed subcomponents. Hubble Space Telescope (HST) observations with the Near-Infrared Camera and Multi-Object Spectrometer (NICMOS) show a bright elliptical galaxy (G1) coincident with the radio position, and a second irregular galaxy (G2) 3.4 arcsec to the northwest. Previous spectroscopic studies have indicated that these galaxies are at different redshifts: z(G1) = 0.624, z(G2) = 0.588. Infrared counterparts to the lensed radio components are not detected in the NICMOS image, and the source redshift has not yet been determined. Preliminary mass modeling based on the VLBA subcomponent data indicates that the lensing potential includes a strong external shear contribution. A VLA monitoring program is currently being undertaken to measure the differential time delay.Comment: 16 pages, 7 figs, several typos corrected, AJ in press (August 2001

Entropy production by Q-ball decay for diluting long-lived charged particles

The cosmic abundance of a long-lived charged particle such as a stau is tightly constrained by the catalyzed big bang nucleosynthesis. One of the ways to evade the constraints is to dilute those particles by a huge entropy production. We evaluate the dilution factor in a case that non-relativistic matter dominates the energy density of the universe and decays with large entropy production. We find that large Q balls can do the job, which is naturally produced in the gauge-mediated supersymmetry breaking scenario.Comment: 8 pages, 1 figur

The Addition Spectrum and Koopmans' Theorem for Disordered Quantum Dots

We investigate the addition spectrum of disordered quantum dots containing spinless interacting fermions using the self-consistent Hartree-Fock approximation. We concentrate on the regime r_s >~1, with finite dimensionless conductance g. We find that in this approximation the peak spacing fluctuations do not scale with the mean single particle level spacing for either Coulomb or nearest neighbour interactions when r_s >~1. We also show that Koopmans' approximation to the addition spectrum can lead to errors that are of order the mean level spacing or larger, both in the mean addition spectrum peak spacings, and in the peak spacing fluctuations.Comment: 35 pages including 22 figures (eps

CLASS B2108+213: A new wide separation gravitational lens system

We present observations of CLASS B2108+213, the widest separation gravitational lens system discovered by the Cosmic Lens All-Sky Survey. Radio imaging using the VLA at 8.46 GHz and MERLIN at 5 GHz shows two compact components separated by 4.56 arcsec with a faint third component in between which we believe is emission from a lensing galaxy. 5-GHz VLBA observations reveal milliarcsecond-scale structure in the two lensed images that is consistent with gravitational lensing. Optical emission from the two lensed images and two lensing galaxies within the Einstein radius is detected in Hubble Space Telescope imaging. Furthermore, an optical gravitational arc, associated with the strongest lensed component, has been detected. Surrounding the system are a number of faint galaxies which may help explain the wide image separation. A plausible mass distribution model for CLASS B2108+213 is also presented.Comment: 9 pages, 8 figures, accepted for publication in MNRA